Evaluation of Clinical Results, Histological Architecture, and Collagen Expression Following Treatment of Mature Burn Scars With a Fractional Carbon Dioxide Laser

Ozog, David M.; Liu, Austin; Chaffins, Marsha; Ormsby, Adrian H.; Fincher, Edgar F.; Chipps, Lisa K.; Mi, Qing Sheng; Grossman, Peter H.; Pui, John; Moy, Ronald L.

doi:10.1001/2013.jamadermatol.668

Cited by 169 publications

(155 citation statements)

References 18 publications

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“…Long-term, persistent gains in function and improvements in scar characteristics probably result from gradual diffuse dermal remodeling and a relative normalization of dysfunctional scar tissue. 5 Despite the promising findings, there are limitations to our results, including the small sample size, the heterogeneity of the patients and treated scars, and the lack of a treatment control. The varied nature of trauma itself confounds the attempt to generate a coherent series at a single center in a reasonable length of time.…”

Section: Discussionmentioning

confidence: 81%

“…Recent reports suggest that AFR can result in consistent enhancements in appearance, function, and symptoms, such as pain and itch, in severe traumatic scars. [5][6][7][8][9] Herein we demonstrate objective functional improvements in 2 pediatric patients with debilitating scar contractures treated with AFR. Their ROM gains occurred after both had plateaued with traditional interventions (ie, therapy and surgery) and coincided temporally with laser surgery (Figs 1 and 2).…”

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confidence: 71%

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Ablative Fractional Laser Resurfacing Helps Treat Restrictive Pediatric Scar Contractures

et al. 2014

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Conventional management of debilitating pediatric scar contractures, including hand therapy and surgery, may often be beset by delayed treatment, suboptimal results, and additional surgical morbidity. Ablative fractional laser resurfacing is an emerging adjunctive procedural option for scar contractures because of its promising efficacy and safety profile. However, its use to improve function has not been studied in the pediatric population. Herein we report 2 pediatric patients with recalcitrant scar contractures, causing persistent functional deficits, treated with an ablative fractional laser protocol. Both patients experienced rapid and cumulative subjective and objective improvements in range of motion and function as measured by an independent occupational therapist without reported complications. We highlight ablative fractional laser resurfacing as a novel and promising tool in the management of function-limiting scar contractures in children and propose that the technique be incorporated into existing scar treatment paradigms, guided by future research.

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Section: Discussionmentioning

confidence: 81%

mentioning

confidence: 71%

Ablative Fractional Laser Resurfacing Helps Treat Restrictive Pediatric Scar Contractures

et al. 2014

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“…The pursuit of good results in treating photo aging and other disorders with fractional CO 2 laser has been studied widely in recent years [14][15][16] , demonstrated in ten patients that lesion depth was proportional to increases in pulse duration.…”

Section: Discussionmentioning

confidence: 99%

Lower energy and pulse stacking. A safer alternative for skin tightening using fractional CO2 laser

et al. 2016

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Intellectual and scientific content of the study, design the protocol, acquisition and interpretation of data, statistical analysis, critical revision. III PhD, Faculty of Medical Sciences, UNICAMP, Campinas-SP, Brazil. Intellectual and scientific content of the study, design the protocol, acquisition and interpretation of data, statistical analysis, critical revision. IV . The same pattern was observed in Group III. At 30 and 60 days, the lowest setting significantly sustained contraction. CONCLUSION:Lower fractional CO 2 laser energies associated to pulse stacking could cause consistent and long lasting tissue contraction in rats.Key words: Lasers, Gas. Skin Aging. Laser Therapy. Rats.Lower energy and pulse stacking. A safer alternative for skin tightening using fractional CO 2 laser

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“…Histologically, scars treated with fractional laser have significantly decreased type I collagen and increased type III collagen which is more similar to normal skin than untreated lesions. 14,15 And what's more, vascular density in the superficial dermis is also improved. 16 There are several reports about using ablative fractional laser in treatment of postsurgical and burns scars.…”

Section: Case Reportmentioning

confidence: 99%

Successful Treatment of Post-Traumatic Elbow Scar Contracture Using Combined Approach of Surgical Release & Early Fractional Laser Resurfacing

et al. 2018

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Scarring is mostly fibrous formation that arises from the regeneration of tissue after a traumatic injury or inflammation. One of the most common and most important morbidities of scar is contracture, particularly when located in the nearby joints. Many surgical techniques, including tissue expansion, skin grafting, local and distant flaps, and Z-or W-plasty can be applied to scar contracture. Currently, non-surgical methods play an important role in scar treatment methods with ablative fractional resurfacing being one of the most effective and promising methods for correcting various types of scar. This paper reports the combined approach of surgical and non-surgical methods of scar treatment to release scar contracture successfully. A nine-year-old male patient with a 30 cm-sized posttraumatic scar on his right arm was treated with an ablative fractional laser device after Z-plasty. The patient received a total of four sessions of laser treatment with a one month interval between sessions. The results were evaluated before the procedure and 2 years after the last fractional laser resurfacing treatment. The mean vancouver scar scale score of the scar rated by two physicians decreased from 9.5 to 3.0. The patient also noted significant improvement in aesthetics and function and was quite satisfied with the results. No complications, such as wound disruption, post-inflammatory hyper pigmentation, or dyspigmentation were noted. The combined approach of surgical release and early fractional laser resurfacing for scar treatment can produce significant aesthetic and functional improvements of scar contracture. Key words

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Evaluation of Clinical Results, Histological Architecture, and Collagen Expression Following Treatment of Mature Burn Scars With a Fractional Carbon Dioxide Laser

Cited by 169 publications

References 18 publications

Ablative Fractional Laser Resurfacing Helps Treat Restrictive Pediatric Scar Contractures

Ablative Fractional Laser Resurfacing Helps Treat Restrictive Pediatric Scar Contractures

Lower energy and pulse stacking. A safer alternative for skin tightening using fractional CO2 laser

Successful Treatment of Post-Traumatic Elbow Scar Contracture Using Combined Approach of Surgical Release & Early Fractional Laser Resurfacing

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