Evaluation of clinical aspects and quality of life as risk factors for depression in patients with epilepsy

Zhao, Ting; Sun, Mingyue; Yu, Peimin; Zhu, Guangfa; Tang, Xiaolin; Shi, Yunbo; Hong, Zhen

doi:10.1016/j.seizure.2012.03.006

Cited by 20 publications

(8 citation statements)

References 27 publications

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“…Among the 43 reports on the incidence rate of depression in epilepsy, 15 were based on a population survey [ 14 , 19 – 22 , 25 – 27 , 35 , 38 , 39 , 45 , 47 , 50 , 52 ], and 28 were clinical studies [ 12 , 13 , 15 – 18 , 23 , 24 , 28 – 34 , 36 , 37 , 40 – 44 , 46 , 48 , 49 , 51 , 53 , 54 ]. In a population-based environment, the combined prevalence of epilepsy in depression patients was 27% (95% CI, 23–31), while the prevalence was 34% in the clinic (95% CI, 30–39) ( Fig 3 ).…”

Section: Resultsmentioning

confidence: 99%

Exploring the association between epilepsy and depression: A systematic review and meta-analysis

et al. 2022

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Objective This study offers meta-analytic data on the potential association between epilepsy and depression especially for the prevalence of depression in epilepsy or vice versa. Methods The relevant studies were searched and identified from nine electronic databases. Studies that mentioned the prevalence and/or incidence of epilepsy and depression were included. Hand searches were also included. The search language was English and the search time was through May 2022. Where feasible, random-effects models were used to generate pooled estimates. Results After screening electronic databases and other resources, 48 studies from 6,234 citations were included in this meta-analysis. The period prevalence of epilepsy ranged from 1% to 6% in patients with depression. In population-based settings, the pooled period prevalence of depression in patients with epilepsy was 27% (95% CI, 23–31) and 34% in clinical settings (95% CI, 30–39). Twenty studies reported that seizure frequency, low income, unemployment of the patients, perception of stigma, anxiety, being female, unmarried status, disease course, worse quality of life, higher disability scores, and focal-impaired awareness seizures were risk factors for depression. Conclusion Our study found that epilepsy was associated with an increased risk of depression. Depression was associated with the severity of epilepsy.

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Section: Resultsmentioning

confidence: 99%

Exploring the association between epilepsy and depression: A systematic review and meta-analysis

et al. 2022

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“…In the past ten years, there have been a number of hospital-based studies regarding the prevalence of depression in PWE in different regions of China. A study in Shanghai, China [33], showed a prevalence of 25.7%, using the Hamilton Depression Rating Scale-17(HAMD-17). Studies from Beijing [34] and Sichuan [23] utilizing the Mini International Neuropsychiatric Interview (MINI) showed a prevalence of 30.2% and 26.7%, respectively.…”

Section: Discussionmentioning

confidence: 99%

Depression in people with epilepsy in West China: Status, risk factors and treatment gap

Deng

Zhu

et al. 2019

Seizure

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To evaluate the prevalence, suicidality and treatment gap (TG) of depression in people with epilepsy (PWE) in West China, and to explore the related risk factors. Methods: A consecutive cohort of PWE from West China Hospital was recruited. The Chinese version of the Neurological Disorders Depression Inventory for Epilepsy scale was used to assess depression and suicidality. Prevalence and TG of depression were calculated. Logistic regression analysis was used to assess risk factors of depression and suicidality. Results: Among a total of 461 participants, there were 29.9% with depression and 15.8% had suicidality. Being female, an unmarried status, disease course, seizure frequency, seizure occurrence in the last 6 months, and focal impaired awareness seizure were risk factors for depression. Depression was an independent risk factor for suicidality. The TG of depression was 72.5%. The TG was larger in the 30-40 year age group, in rural populations, and among those with a disease course between 5 and 10 years. The TG figures dropped with increasing annual family income. Conclusions: The prevalence of depression and the rate of suicide risk for PWE in West China are high. A large TG for depression exists in PWE. Clinicians should focus on depression and suicidality for PWE and identify the related risk factors in a timely manner so as to reduce the incidence of depression and suicide. Management including public education as well as professional training of neurologists are necessary to fill the TG.

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“…Moreover, psychiatric comorbidity might influence the choice of antiepileptic drug therapy, the effectiveness of the treatment, and, more generally, the patients' quality of life [2,[6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Very recently, particularly in the last decade, numerous studies have focused on the relationship between epilepsy and psychological disturbances [11,12]. It was generally found that depression and anxiety have the highest prevalence among patients with epilepsy [3,12,13].…”

Section: Introductionmentioning

confidence: 99%

Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures

Russo

Chimirri

Aiello

et al. 2013

Epilepsy & Behavior

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Evaluation of clinical aspects and quality of life as risk factors for depression in patients with epilepsy

Cited by 20 publications

References 27 publications

Exploring the association between epilepsy and depression: A systematic review and meta-analysis

Exploring the association between epilepsy and depression: A systematic review and meta-analysis

Depression in people with epilepsy in West China: Status, risk factors and treatment gap

Lamotrigine positively affects the development of psychiatric comorbidity in epileptic animals, while psychiatric comorbidity aggravates seizures

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