Evaluation of Children with Acute Bacterial Meningitis Treated in Two Separate Time Periods in Turkey

Uzun, Aysun Kara; Yöney, Aysel; Kunak, Benal; Yüksek, Saliha Kanık; Tezer, Hasan

doi:10.12956/tjpd.2017.312

Cited by 1 publication

(1 citation statement)

References 6 publications

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“…Septic shock was reported in approximately 40% of patients in the studies from the EM region, while hemodynamic disorder/sepsis were reported in over half of patients in the study from the NA region. Data on post-discharge complications and sequelae were available from eight EM region studies (Kuwait n = 2 [ 93 , 94 ]; Qatar n = 2 [ 52 , 69 ]; Saudi Arabia n = 2 [ 53 , 71 ]; and Turkey n = 2 [ 98 , 99 ]) and two NA region studies (Egypt n = 1 [ 78 ] and Tunisia n = 1 [ 89 ]). The majority of studies in the EM region reported non-specified sequelae; there was little overlap across studies in terms of specific reported events for either region.…”

Section: Objective 3: Imd Presentation and Managementmentioning

confidence: 99%

Systematic review of invasive meningococcal disease epidemiology in the Eastern Mediterranean and North Africa region

Dogu

Oordt-Speets²,

Bruijn³

et al. 2021

BMC Infect Dis

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Background Invasive meningococcal disease (IMD) represents a global health burden. However, its epidemiology in the Eastern Mediterranean (EM) and North Africa (NA) regions is currently not well understood. This review had four key objectives: to describe asymptomatic meningococcal carriage, IMD epidemiology (e.g. serogroup prevalence, case-fatality rates [CFRs]), IMD presentation and management (e.g. clinical diagnosis, antibiotic treatments) and economic impact and evaluation (including health technology assessment [HTA] recommendations) in EM and NA. Methods A systematic literature search (MEDLINE and EMBASE) was conducted (January 2000 to February 2021). Search strings included meningococcal disease and the regions/countries of interest. Identified publications were screened sequentially by title/abstract, followed by screening of the full-text article; articles were also assessed on methodological quality. Literature reviews, genetic sequencing or diagnostic accuracy studies, or other non-pertinent publication type were excluded. An additional grey literature search (non-peer-reviewed sources; start date January 2000) was conducted to the end of April 2019. Results Of the 1745 publications identified, 79 were eligible for the final analysis (n = 61 for EM and n = 19 for NA; one study was relevant to both). Asymptomatic meningococcal carriage rates were 0–33% in risk groups (e.g. military personnel, pilgrims) in EM (no data in NA). In terms of epidemiology, serogroups A, B and W were most prevalent in EM compared with serogroups B and C in NA. IMD incidence was 0–20.5/100,000 in EM and 0.1–3.75/100,000 in NA (reported by 7/15 countries in EM and 3/5 countries in NA). CFRs were heterogenous across the EM, ranging from 0 to 57.9%, but were generally lower than 50%. Limited NA data showed a CFR of 0–50%. Data were also limited in terms of IMD presentation and management, particularly relating to clinical diagnosis/antibiotic treatment. No economic evaluation or HTA studies were found. Conclusions High-risk groups remain a significant reservoir of asymptomatic meningococcal carriage. It is probable that inadequacies in national surveillance systems have contributed to the gaps identified. There is consequently a pressing need to improve national surveillance systems in order to estimate the true burden of IMD and guide appropriate prevention and control programmes in these regions.

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