Evaluation of chemokine CXCL12 level with oxidative stress in breast cancer

Abstract

Cancer is a major public health problem worldwide, and cancer is a term given to a group of diseases characterized by abnormal growth and proliferation of cells as a result of uncontrolled cell divisions or tumor suppressor genes. The current study was included an evaluation of chemokine CXCL12 level with oxidative stress in women with breast cancer. The study included the collection of 90 blood samples for women, and the samples were distributed into 50 samples for women with breast cancer, their ages ranged from 40-70 years, the samples were collected from the Breast Cancer Center in Baquba General Hospital, and 40 blood samples for healthy women as a control group, and their same ages, during the period from the beginning of October 2021 until the end of December 2021. The results showed that there was a significant increase in the level of chemokine CXCL12 in women with breast cancer compared to the healthy women. Also, showed a significant increase in the level of malondialdehyde and nitric oxide, with a significant decrease in the level of Glutathione in the women with breast cancer woman compared to the healthy women.