Evaluation of chemical composition, in vitro antioxidant, and antidiabetic activities of solvent extracts of Irvingia gabonensis leaves

Atanu, Francis O.; Ikeojukwu, Arinzechukwu; Owolabi, Peter  A.; Avwioroko, Oghenetega J.

doi:10.1016/j.heliyon.2022.e09922

Cited by 12 publications

(16 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Complete inhibition of amylase is counterproductive as it leads to the accumulation of undigested starch, promoting the growth of intestinal microflora and causing gastrointestinal disorders such as diarrhea, abdominal pain, and flatulence. [33] Plants rich in phenolic compounds are well-known for their ability to inhibit α-amylase and α-glucosidase, thereby reducing postprandial blood glucose levels. [34] In our study, we observed that methanol extracts with the highest phenolic content also exhibited the strongest inhibitory activity against both enzymes.…”

Section: Discussionmentioning

confidence: 99%

“…However, it is essential for an ideal oral hypoglycemic drug to exhibit milder inhibitory activity on α‐amylase compared to α‐glucosidase. Complete inhibition of amylase is counterproductive as it leads to the accumulation of undigested starch, promoting the growth of intestinal microflora and causing gastrointestinal disorders such as diarrhea, abdominal pain, and flatulence [33] . Plants rich in phenolic compounds are well‐known for their ability to inhibit α‐amylase and α‐glucosidase, thereby reducing postprandial blood glucose levels [34] .…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant and Antidiabetic Potential of Ormocarpum cochinchinense (Lour.) Merr. Leaf: An Integrated In vitro and In silico Approach

Katturajan,

Shivaji,

Nithiyanandam

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Diabetes is a prevalent metabolic disorder associated with various complications. Inhibition of α‐glucosidase and α‐amylase enzymes is an effective strategy for managing non‐insulin‐dependent diabetes mellitus. This study aimed to investigate the antioxidant and antidiabetic potential of Ormocarpum cochinchinense leaf through in vitro and in silico approaches. The methanol extract exhibited the highest phenolic and flavonoid content over solvent extracts aqueous, acetone, hexane and chloroform, same has been correlating with strong antioxidant activity. Furthermore, the methanol extract demonstrated significant inhibitory effects on α‐amylase and α‐glucosidase enzymes, indicating its potential as an antidiabetic agent. Molecular docking analysis identified compounds, including myo‐inositol, with favorable binding energies comparable to the standard drug metformin. The selected compounds displayed strong binding affinity towards α‐amylase and α‐glucosidase enzymes. Structural dynamics analysis revealed that myo‐inositol formed a more stable complex with the enzymes. These findings suggest that O. cochinchinense leaf possesses antioxidant and antidiabetic properties, making it a potential source for developing therapeutic agents.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antioxidant and Antidiabetic Potential of Ormocarpum cochinchinense (Lour.) Merr. Leaf: An Integrated In vitro and In silico Approach

Katturajan,

Shivaji,

Nithiyanandam

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…Phytosterols such as stigmasterol and campesterol exert metabolic effects [55], and possess antioxidant, antimicrobial, and photoprotective properties [56]. Gamma-sitosterol is a natural product with antioxidant, antimicrobial, antidiabetic, and photoprotective properties [56,57]. Alpha-amyrin is a natural product derived from ursane with antibiofilm properties against methicillin-resistant and vancomycin intermediate-resistant Staphylococcus aureus [58].…”

Section: Discussionmentioning

confidence: 99%

Sloanea chocoana and S. pittieriana (Elaeocarpaceae): Chemical and Biological Studies of Ethanolic Extracts and Skincare Properties

Quintero-Rincón,

Pino-Benítez,

Galeano

et al. 2023

Plants

View full text Add to dashboard Cite

The Colombian Chocó is known for its rich biodiversity and to harbor plant species that are under-explored, including the genus Sloanea. This study aimed to analyze the chemical composition of derivatized ethanolic extracts from S. chocoana and S. pittieriana using BSTFA and TMCS through GC–MS, and to assess cell viability of immortalized human non-tumorigenic keratinocytes (HaCaT) and periodontal ligament fibroblast cells using crude extracts through MTS assay. Antioxidant and photoprotective properties were determined using DPPH assay and spectrophotometry. Antifungal activity of extracts against Candida species was developed following the CLSI standard M27, 4th ed. The sun protective factor (SPF) and UVA/UVB ratio values were calculated using the Mansur equation and the Boots star rating system. The critical wavelength (λc) was determined by calculating the integrated optical density curve’s area. The transmission of erythema and pigmentation was calculated through equations that use constants to calculate the flux of erythema and pigmentation. The GC–MS analysis identified 37 compounds for S. chocoana and 38 for S. pittieriana, including alkaloids, triterpenoids, and polyphenolics, among others. Both extracts exhibited proliferative effects on periodontal ligament fibroblasts, did not affect the viability of HaCaT cells, and showed excellent antioxidant activities (46.1% and 43.7%). Relevant antifungal activity was observed with S. pittieriana extract against Candida albicans (GM–MIC: 4 µg/mL), followed by C. auris and C. glabrata (GM–MIC: 32 µg/mL), while S. chocoana extract was active against C. albicans and C. glabrata (GM–MIC: 16 and 32 µg/mL, respectively). High SPF values (31.0 and 30.0), λc (393.98 and 337.81 nm), UVA/UVB ratio (1.5 and 1.2), and low percentage of transmission of erythema and pigmentation were determined for S. chocoana and S. pittieriana, respectively. Results showed that species of Sloanea constitute a promising alternative as ingredients for developing skincare products, and exhaustive studies are required for their sustainable uses.

show abstract

“…Herbal dietary therapy provides a secure and affordable alternative to the existing pharmacological approaches (Hanhineva et al, 2010;Chang et al, 2013;Cao et al, 2019;Storz and Kuster, 2019). Mangifera indica leaves (MIL) have been found to be a rich source of phenolic acids and flavonoids (Batool et al, 2018;Atanu et al, 2022). In previous studies, rats were induced to develop T2D using a high-fat diet and the drug streptozotocin (HFD/STZ).…”

Section: Discussionmentioning

confidence: 99%

Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats

Maghfur

Shahat

Soliman

2022

Egyptian Academic Journal of Biological Sciences, B. Zoology

View full text Add to dashboard Cite

Because synthetic antidiabetic medications have undesirable side effects and are expensive, various studies on medicinal plants with hypoglycemic properties have continued looking for alternative ways to prevent and manage type 2 diabetes (T2D) that may be more efficient, cost-effective and secure. Efficient bioactive substances such as flavonoids, tannins, alkaloids, terpenoids, anthraquinones, saponins, cardiac glycosides, and steroids were discovered in Mangifera indica leaves (MIL). The study's goal was to evaluate the MIL's therapeutic potential in diabetic rats treated with streptozotocin (STZ). In the experiment, forty male adult albino rats were employed. The animals were separated into four groups, each with ten rats, and evaluated as follows: group 1 (healthy control, HC); group 2 (untreated diabetic, UD); group 3 (mango treated diabetic, MTD); and group 4 (mango treated, MT). After 8 weeks of MIL extract administration, blood samples were taken to assess several biochemical and hematological markers. The treatment of MIL extract in diabetic rats resulted in significant reductions in blood glucose, glycated hemoglobin (HbA-1c), and amylase enzyme activity. The levels of insulin, vitamin C, and vitamin E were significantly increased with MIL extract treatment. Further, the extract showed significant antihyperlipidemic activity and renoprotective and hepatoprotective effects in diabetic rats. These findings suggested a beneficial effect of MIL extract in the treatment of T2D associated with hyperlipidemia, and liver and kidney complications.

show abstract

Evaluation of chemical composition, in vitro antioxidant, and antidiabetic activities of solvent extracts of Irvingia gabonensis leaves

Cited by 12 publications

References 37 publications

Antioxidant and Antidiabetic Potential of Ormocarpum cochinchinense (Lour.) Merr. Leaf: An Integrated In vitro and In silico Approach

Antioxidant and Antidiabetic Potential of Ormocarpum cochinchinense (Lour.) Merr. Leaf: An Integrated In vitro and In silico Approach

Sloanea chocoana and S. pittieriana (Elaeocarpaceae): Chemical and Biological Studies of Ethanolic Extracts and Skincare Properties

Assessment of The Therapeutic Role of Mangifera indica Leaves Extract in Diabetic Albino Rats

Contact Info

Product

Resources

About