Evaluation of ceruloplasmin levels in patients undergoing surgical interventions with nasal polyps

Bozkus, Ferhat; Ulaş, Turgay; San, Imran; Yeşilova, Yavuz; İynen, İsmail; Güldür, Muhammed Emin; Aksoy, Nurten

doi:10.1016/j.anl.2012.07.018

Cited by 8 publications

(11 citation statements)

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“…CP is known as an acute phase reactant and an antioxidant parameter in inflammatory diseases, and has been observed in elevated levels in several chronic inflammatory diseases 23 , 24 , 25 , 26 , 28 , 29 , 30 , 31 ) . In a study measuring inflammatory marker protein levels in elevated plasma inflammation, CP levels were shown to be associated with an increased incidence of chronic obstructive pulmonary disease requiring hospitalization 23 ) .…”

Section: Discussionmentioning

confidence: 99%

“…Ceruloplasmin (CP) is an acute phase reactant and antioxidant, characterized by ferroxidase activity and increases in inflammation. Blood serum CP levels are correlated with presence of inflammatory diseases such as chronic obstructive pulmonary disease, rheumatoid arthritis, systemic lupus erythematosus, Behcet’s Disease, nasal polyps, cystic echinococcus, and obesity 23 , 24 , 25 , 26 ) .…”

Section: Introductionmentioning

confidence: 99%

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Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis

et al. 2016

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[Purpose] To evaluate serum ceruloplasmin levels in geriatric patients with osteoporosis. [Subjects and Methods] Seventy geriatric patients over 65 years of age were recruited. Patients were divided into two groups: group 1 (‘OP’, n=35) consisted of patients with osteoporosis, and group 2 (n=35) consisted of patients without osteoporosis. Dual-energy X-ray absorptiometry scanning was used in the measurement of bone mineral density in all cases. Inflammatory parameters, including C-reactive protein, sedimentation rate, and serum ceruloplasmin levels were analyzed in blood samples. [Results] No statistical differences in inflammatory parameters were observed between the two groups, however, serum ceruloplasmin levels were significantly higher in group 1 than in group 2. In Pearson analysis, serum ceruloplasmin levels were not found to be correlated with any biochemical parameters. Receiver operator characteristic curve analysis revealed that serum ceruloplasmin levels were predictive of osteoporosis with 85.7% sensitivity and 85.7% specificity over the level of 830.15. [Conclusion] Our study demonstrated that measurement of serum ceruloplasmin levels may have potential as a screening methodology for geriatric patients with osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis

et al. 2016

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“…Nasal‐polyp staging of nasal‐polyp patients was performed with the help of the Lund‐Kennedy staging system. [ 17,18 ] The staging was as follows: stage 0 for the absence of polyps; stage 1 for patients with polyps not prolapsing beyond the middle turbinate; stage 2 for patients with polyps extending below the middle turbinate; stage 3 for patients with massive polyps occluding the entire nasal cavity and resulting in a maximum score of 3 per side. Radiologically, the Lund‐Mackay staging system was used in the assessment of the paranasal sinus computed tomography (CT) scans.…”

Section: Methodsmentioning

confidence: 99%

Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population

Avcıkurt

Gençer

Yazıcı

2020

J Biochem & Molecular Tox

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The pathogenesis of nasal polyps is not completely understood. Oxidative damage contributes to polyp formation in the nasal mucosa. The paraoxonase 1 (PON1) enzyme is an important liver enzyme with high antioxidant activity. In this study, we investigated the correlation between Q192R genotypic polymorphism of the PON1 enzyme and nasal‐polyp disease. The study examined 62 nasal‐polyp patients and 88 controls. PON1 Q192R polymorphism was determined using polymerase chain reaction‐restriction fragment length polymorphism. The genotype distribution of the PON1 gene was significantly different between nasal‐polyp patients (QQ = 69.35%, QR = 25.81%, RR = 4.83%) and healthy controls (QQ = 52.27%, QR = 44.31%, RR = 3.40%). Our results suggest that the PON1 QQ genotype (odds ratio [OR] = 2.066, P = .036) is associated with a higher risk of developing the nasal‐polyp disease while QR genotype (OR = 0.437, P = .021) showed a lower risk.

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Section: Introductionmentioning

confidence: 99%

“…CRSwNP has a multifactorial etiology, inflammation playing one of the most important roles [8][9][10][15][16][17][18][19] . The involvement of oxidative stress (OS) in the pathogenesis of CRSwNP is being mentioned more frequently in recent studies 9,10,[15][16][17][18][19][20][21] . Oxidative stress is a term used to describe the diseases caused by reactive oxygen species (ROS), which have a destructive and pathogenic character.…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress-related pathophysiology in chronic rhinosinusitis with nasal polyps: research challenges

Istratenco

2019

Romanian Journal of Rhinology

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Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a multifactorial pathology with negative impact on the quality of life and considerable socio-economic effects. The pathogenesis of CRSwNP has not yet been fully elucidated despite remarkable studies in this field. This limits the pathogenic treatment and, therefore, the pathological process is expressed by a greater tendency of recurrence. Patients with recurrent CRSwNP remain in a severe state and therapeutically uncontrolled. In recent studies, the involvement of oxidative stress (OS) in the pathogenesis of CRSwNP has been more frequently mentioned. CRSwNP is considered a response of the sinonasal tissue on the inflammatory state, associated with OS and production of reactive oxygen species, causing injury to sinonasal tissues. It was demonstrated that the amount of ROS in the nasal polyp tissue corresponds to the severity of CRSwNP. A literature review on the role of OS in the pathogenesis of CRSwNP was undertaken. The relevant information was identified using a search of electronic databases. Keywords used to highlight relevant papers were a combination of “chronic rhinosinusitis with nasal polyps” and “oxidative stress”. This review demonstrates that there is a strong relationship between OS and CRSwNP pathogenesis. It is hypothesized that antioxidants may have a preventive role in CRSwNP. Nevertheless, additional research is required to further evaluate the effectiveness of antioxidant therapy.

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Evaluation of ceruloplasmin levels in patients undergoing surgical interventions with nasal polyps

Cited by 8 publications

References 36 publications

Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis

Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis

Q192R polymorphism in the PON1 gene and nasal polyp in a Turkish population

Oxidative stress-related pathophysiology in chronic rhinosinusitis with nasal polyps: research challenges

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