Usefulness of ceruloplasmin testing as a screening methodology for geriatric patients with osteoporosis

Abstract

[Purpose] To evaluate serum ceruloplasmin levels in geriatric patients with osteoporosis. [Subjects and Methods] Seventy geriatric patients over 65 years of age were recruited. Patients were divided into two groups: group 1 (‘OP’, n=35) consisted of patients with osteoporosis, and group 2 (n=35) consisted of patients without osteoporosis. Dual-energy X-ray absorptiometry scanning was used in the measurement of bone mineral density in all cases. Inflammatory parameters, including C-reactive protein, sedimentation rate, and serum ceruloplasmin levels were analyzed in blood samples. [Results] No statistical differences in inflammatory parameters were observed between the two groups, however, serum ceruloplasmin levels were significantly higher in group 1 than in group 2. In Pearson analysis, serum ceruloplasmin levels were not found to be correlated with any biochemical parameters. Receiver operator characteristic curve analysis revealed that serum ceruloplasmin levels were predictive of osteoporosis with 85.7% sensitivity and 85.7% specificity over the level of 830.15. [Conclusion] Our study demonstrated that measurement of serum ceruloplasmin levels may have potential as a screening methodology for geriatric patients with osteoporosis.

Serum Proteomic Analysis Reveals Vitamin D-Binding Protein (VDBP) as a Potential Biomarker for Low Bone Mineral Density in Mexican Postmenopausal Women

“…The physiological function of ceruloplasmin, (CP) includes copper transport, regulation of cellular iron levels, and antioxidant activity by eliminating reactive oxygen species, such as superoxide and hydroxyl radicals [35]. A recent study showed that CP activity was significantly higher in patients with osteoporosis compared to healthy individuals [36]. However, CP levels have never been investigated in osteoporosis patients.…”

Indices of metal proteins (transferrin ceruloplasmin) in overweight and obese children

“…One of the tasks of modern medicine is to find new markers that allow to deal with issues of early diagnosis to prevent destructive changes in the body, to predict the severity and course of illness, to timely detect their complications, and foremost to evaluate the effectiveness of conservative therapy. The researchers' data show that the information about the biological and clinical significance in the inflammation process of metal proteins such as ceruloplasmin (in a population of adolescents with metabolic syndrome 24 , from overweight and obese subjects 25 , in insulin-dependent diabetes mellitus [26][27][28] , in patients with osteoporosis 29 , ferritin, transferrin [30][31][32] is in great demand, as metal proteins are blood proteins that take part in depositing, transporting and disinfecting metal ions of variable valency. The importance of the research of the proteins lies in their role in the antioxidant system's functioning.…”

Preoperative Lymphocyte to Monocyte Ratio Can Be a Prognostic Factor in Arthroscopic Repair of Small to Large Rotator Cuff Tears

“…Usually, inflammation is evaluated by erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP). 17 However, whether ESR or CRP is elevated in systemic inflammation-related disorders remains controversial, 14,28,46,59 which might result from the fact that CRP is mainly a response of hepatocyte to IL-6, whereas ESR can be affected by many noninflammatory factors. 24 Considering the complexity of systemic inflammation, which involves multiple cytokines and cells, more comprehensive markers are needed.…”