Evaluation of Central and Peripheral Corneal Thickness with Ultrasound Biomicroscopy in Normal and Keratoconic Eyes

Avitabile, Teresio; Marano, Filippo; Uva, Maurizio G.; Reibaldí, A.

doi:10.1097/00003226-199711000-00007

Cited by 64 publications

(43 citation statements)

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“…[34][35][36][37][38][39] Mandell and Polse 34 pioneered the investigations of corneal thickness profile in a study using a modified Haag-Streit optical pachymeter with an electronic recording system to document the variation in thickness over the horizontal meridian measured at different angles. In their study, the difference between the central and the peripheral measurements was much greater in eyes with keratoconus; it was most significant at the 35-degree position, where the authors found a difference greater than 0.085 mm as pathognomonic of keratoconus.…”

Section: Discussionmentioning

confidence: 99%

“…Avitabile et al 35 defined a keratoconus index that evaluated the ratio between the mean peripheral corneal thickness and the thinnest point measured by ultrasound biomicroscopy (UBM). The keratoconus index proved to be very sensitive, detecting significantly different values between normal corneas and keratoconic corneas (P!.001, Student t test).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Corneal-thickness spatial profile and corneal-volume distribution: Tomographic indices to detect keratoconus

Ambrósio¹,

Alonso²,

Luz³

et al. 2006

Journal of Cataract and Refractive Surgery

399

262

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Corneal-thickness spatial profile, corneal-volume distribution, percentage increase in thickness, and percentage increase in volume were different between keratoconic corneas and normal corneas and could serve as indices to diagnose keratoconus and screen refractive candidates. Further studies are necessary to evaluate whether these tomographic indices are more sensitive and specific than the classic Placido-based topography.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Corneal-thickness spatial profile and corneal-volume distribution: Tomographic indices to detect keratoconus

Ambrósio¹,

Alonso²,

Luz³

et al. 2006

Journal of Cataract and Refractive Surgery

399

262

View full text Add to dashboard Cite

show abstract

“…As long as the cornea treated has a minimum thickness of 400 lm (as recommended), the corneal endothelium will not experience damage, nor will deeper structures such as lens and retina. The light source should provide a homogenous irradiance, avoiding hot spots [69][70][71][72][73].…”

Section: Risks and Side Effectsmentioning

confidence: 99%

Corneal collagen cross-linking using riboflavin and ultraviolet-A irradiation: a review of clinical and experimental studies

2011

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Corneal collagen cross-linking (CXL) using riboflavin and ultraviolet-A irradiation is a common method of tissue stabilization and has been developed primarily to address the need of treating keratoconus. CXL's promising results on keratoconus indicated that it might be effective in other corneal diseases as well. This new treatment promises a slowing effect on the progression of these diseases and its initial results show that it is safe and reasonably curative. The purpose of this review is to critically evaluate this treatment, to explore its benefits, to highlight its limitations in terms of efficacy and long-term safety and finally to identify areas for future research in this topic with a significant potential to change the way we treat our patients. In addition, in this unbiased review we try to bring together all the scientific information from both laboratory and clinical trials that have been conducted during recent years and to review the most recent publications regarding the therapeutic indications of CXL.

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“…Ultrasonik yöntemler aras›nda ultrasonik pakimetre ve ultrasonik biyomikroskop (UBM), optik yöntemler aras›nda ise speküler mikroskopi, optik koherans tomografi, taray›c› slit kornea topografisi, konfokal mikroskopi ve Pentacam Scheimpflug sistem say›labilir. 1,[7][8][9][10][11][12][13][14][15][16][17] Ultrasonik pakimetri, ucuz ve kolay uygulanabilir bir teknoloji olmas›, ölçümlerinin yüksek tekrarlanabilirlikte ve güvenilirlikte olmas› nedeniyle klinik uygulamalarda yayg›n olarak kullan›lmaktad›r. 13,[18][19][20] Korneaya temas etmesi en önemli dezavantaj›d›r ve epitel defektlerine ve enfeksiyonlara yol açabilmektedir.…”

Section: Giriflunclassified

Pentacam ile Ölçülen Santral Kornea Kalınlıklarının Karşılaştırılması

Büyük¹,

Bozkurt²,

Kamış³

et al. 2011

tjo

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ÖzetAmaç: Normal ve keratokonuslu gözlerde ultrasonik pakimetre (Ocuscan ® RxP) ve OCULUS Pentacam Scheimpflug kamera ile ölçülen santral kornea kal›nl›k (SKK) de¤erlerinin karfl›laflt›r›lmas› Gereç ve Yöntem: Prospektif çal›flmada 57 keratokonuslu, 62 sa¤l›kl› gözün s›ras›yla Pentacam ve ultrasonik pakimetre ile SKK ölçümleri yap›ld›. Her iki cihaz ölçümlerinin ortalamas› efllendirilmifl dizide t testi ile istatistiksel olarak karfl›laflt›r›ld› ve p<0,05 istatistiksel olarak anlaml› kabul edildi. Her iki cihaz ile al›nan SKK ölçümleri aras›ndaki iliflki Pearson testi ile de¤erlendirildi. Sonuçlar: Keratokonuslu gözlerin ortalama SKK ölçümleri Pentacam cihaz› ile 480,18±33,6 μm, ultrasonik pakimetre ile 465,67±34,5 μm olarak bulundu ve farkl›l›k istatistiksel olarak anlaml› idi (t=-5,87; p<0,001). Sa¤l›kl› gözlerde ise bu de¤erler s›ras›yla 573,8±35,7 μm ve 563,58±30,9 μm olarak ölçüldü (t=-4,32; p<0,001). Sa¤l›kl› grupta 15 gözün SKK de¤erleri ultrasonik pakimetre ile 585 μm üzerindeydi ve bu gözlerin Pentacam ve ultrasonik pakimetre ile al›nan ölçümleri s›ras›yla 619±13,1 μm ve 608,87±14,1 μm olarak bulundu (t=-3,3; p=0,005). Her iki cihaz ile al›nan ölçümler birbiriyle anlaml› korelasyon göstermekteydi (r=0,95, p<0,001). Material and Method:In this prospective study, CCT measurements were done in 57 keratoconic eyes and 62 healthy eyes by OCULUS Pentacam and ultrasonic pachymetry, consecutively. The measurements taken by the 2 instruments were compared with paired-samples t-test. A p value <0.05 was considered as statistically significant. The correlation between the measurements was evaluated using the Pearson test. Results: The mean CCT of keratoconic eyes was 480.18±33.6 μm with Pentacam and 465.67±34.5 μm with ultrasonic pachymetry, which demonstrates a statistically significant difference (t=-5.87; p585 μm (t=-3.3; p=0.005). There was a high correlation between the CCT readings done by the two methods (r=0.95, p<0.001). Discussion: The CCT measurements obtained by Pentacam in both keratoconic and healthy eyes highly correlated with the ultrasonic measurements. However, the CCT measurements taken by Pentacam were higher compared to the ultrasonic measurements; therefore, one and the same imaging technique should be used in follow-up measurements. (Turk J Ophthalmol 2011; 41: 104-7)

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Evaluation of Central and Peripheral Corneal Thickness with Ultrasound Biomicroscopy in Normal and Keratoconic Eyes

Cited by 64 publications

References 0 publications

Corneal-thickness spatial profile and corneal-volume distribution: Tomographic indices to detect keratoconus

Corneal-thickness spatial profile and corneal-volume distribution: Tomographic indices to detect keratoconus

Corneal collagen cross-linking using riboflavin and ultraviolet-A irradiation: a review of clinical and experimental studies

Pentacam ile Ölçülen Santral Kornea Kalınlıklarının Karşılaştırılması

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