Evaluation of cellular uptake, cytotoxicity and cellular ultrastructural effects of heteroleptic oxidovanadium(IV) complexes of salicylaldimines and polypyridyl ligands

Interaction of [VIVO(acac)2] with Human Serum Transferrin and Albumin

“…Globally the total amount of vanadium analyzed by ICP‐MS in the A2780 ovarian cells after 24 h of incubation with [V IV O(acac) 2 ] is low (about 30 % or less of those of Cu and Zn amounts found in the same study, carried out with other types of complexes), and more than 60 % is localized on its membrane. The nature of the V‐species present either in the membrane or in each of the cells’ compartments is not known, and probably the amount found in the nucleus is too low to affect it.…”

Vanadium: History, chemistry, interactions with α-amino acids and potential therapeutic applications

“…Vanadium compounds have not only been studied as antidiabetic and insulinomimetic agents, but also for the treatment of parasitic diseases of tropical origin, for cancer and as protectors of tissue damage induced by chemical agents and oxidative stress [2,5,[175][176][177][178][179]. Some vanadium compounds, such as vanadylsulphate, sodium vanadate and peroxidovanadates have shown antitumor activity in experimental models in vitro and in vivo [177][178][179][180][181][182].…”

“…Vanadium compounds have not only been studied as antidiabetic and insulinomimetic agents, but also for the treatment of parasitic diseases of tropical origin, for cancer and as protectors of tissue damage induced by chemical agents and oxidative stress [2,5,[175][176][177][178][179]. Some vanadium compounds, such as vanadylsulphate, sodium vanadate and peroxidovanadates have shown antitumor activity in experimental models in vitro and in vivo [177][178][179][180][181][182]. Vanadocene dichloride [183], vanadium(III)-L-cysteine complexes [47], complexes Metvan [V IV O(SO 4 )(4,7-Mephen) 2 ] [2, 24,184], vanadium complexes with flavonoids and other polyphenols [185], semicarbazone derivatives [186], vanadium-Schiff base complexes [179,187], have demonstrated antitumor properties, which have been studied in different types of cell lines, inhibiting cell proliferation throughout the range of concentrations studied.…”

“…Some vanadium compounds, such as vanadylsulphate, sodium vanadate and peroxidovanadates have shown antitumor activity in experimental models in vitro and in vivo [177][178][179][180][181][182]. Vanadocene dichloride [183], vanadium(III)-L-cysteine complexes [47], complexes Metvan [V IV O(SO 4 )(4,7-Mephen) 2 ] [2, 24,184], vanadium complexes with flavonoids and other polyphenols [185], semicarbazone derivatives [186], vanadium-Schiff base complexes [179,187], have demonstrated antitumor properties, which have been studied in different types of cell lines, inhibiting cell proliferation throughout the range of concentrations studied. The chemical structure of different vanadium compounds with antitumor activity is shown in Fig.…”

“…Another important mechanism, of some vanadium compounds to also exhibit antiproliferative and cytotoxic effects, might be through interactions with DNA [24,179,225,226] either by interacting with DNA's nucleotide phosphate groups as propose in the case of vanadocene complexes [183,227] or through the direct intercalation with DNA such as vanadium complex of 4-pyridinecarboxylic acid, 2-[(2-hydroxy)-1-naphthalenylene] hydrazide and 1,10phenanthroline (VO-(Pahn)phen), resulting in increased ROS and oxidative DNA damage [191,198,228]. Some vanadecene complexes with non-essential amino acids have been reported in the literature [183,229], such as proline and glycine; however, it is unknown whether this class of complexes produces antitumor effects or whether it is capable of interacting with the genetic material.…”