Oxidovanadium(IV/V) complexes bound with a ONS donor backbone: The search for therapeutic versatility in one class of compounds

Abstract

Among the multifarious approaches to treat health challenges such as microbial infections, cancers, and diabetes, metallotherapy is a very significant one. Many transition metal‐based candidates have been previously developed that displayed promising therapeutic interests. Vanadium is one such biologically important transition metal, and in the present work, we have developed potent bioactive vanadium complexes, namely, [{VVO(hpdbal‐smdt)}2μ‐O] (1), [VVO(hpdbal‐smdt)(bha)] (2), [VVO(hpdbal‐smdt)(cat)] (3), [VIVO(hpdbal‐smdt)(phen)] (4), and [VIVO(hpdbal‐smdt)(bipy)] (5), which were synthesized using a ONS donor‐based ligand, H2hpdbal‐smdt (H2L), and [VO(acac)2] alongside secondary ligands, benzohydroxamic acid (bha), catechol (cat), 1,10‐phenanthroline (phen), and 2,2′‐bipyridyl (bipy), respectively. The complexes were mainly characterized using electron paramagnetic resonance (EPR), 1H‐NMR, 13C‐NMR, and infrared (IR) spectroscopy techniques. The ligand was additionally characterized using a single‐crystal X‐ray diffraction (XRD) technique. The compounds were tested for their therapeutic versatility, namely, glucose uptake activity, free radical scavenging activity, and growth inhibitory action towards resilient microbial strains and liver cancer cells. The oxo‐bridged dinuclear vanadium complex (1) showed promising growth inhibitory activity against Pseudomonas aeruginosa bacterial species. Secondary ligand tethered compound (2) displayed notable toxicity against the human liver cancer cells. All complexes induced glucose uptake by the insulin‐resistant cells and exhibited moderate to high antioxidant potential. pH titration and interaction study of these complexes with bovine serum albumin were conducted to investigate solution stability and protein binding properties.

Dithiocarbazate ligands and their Ni(II) complexes with potential biological activity: Structural, antitumor and molecular docking study

“…The Schiff bases are organic compounds widely studied due to their applications in bioinorganic chemistry. In this sense, dithiocarbazates stand out, which are ligands that show different biological activities (Nanjundan et al, 2017;Kongot et al, 2019;Lima et al, 2020;Samy and Omar, 2020;Ramilo-Gomes et al, 2021;Yusof et al, 2022), with emphasis on antitumor action. Recently, studies described copper and vanadium complexes with dithiocarbazates with interesting results and showing an IC 50 value much better than that of cisplatin (Gou et al, 2021;Sahu et al, 2022).…”

Polar and nonpolar iron (II) complexes of isatin hydrazone derivatives as effective catalysts in oxidation reactions and their antimicrobial and anticancer activities

“…The obvious role of M n+ in the coordination compounds, transition metal complexes, in the inhibition of the microbial and cancer growth (Tweedy's chelation theory), was explored in many research studies concerning its importance to promote their compounds' bioreactivity. [25][26][27][28][29][30][31][32][33] Considering the progressed biological application of metalated hydrazone derivatives in alternative pharmaceutical and medicinal fields, many published articles highlighted on their bio-applications. [25,26] The biological studies of Fe (III)-complex of isatin carbohydrazone Schiff base ligand was recently reported, which demonstrated valuable obtains.…”

“…[29] The antioxidant activity against glioma cells of Fe (III) and Cu (II)-complexes of hydroxy-pyridinylaminophenol was investigated with appreciable results, as reported by Seco et al [30] The biological and phenoxazinone synthase-like activities of various Fe (III) complexes of Schiff base derivatives were explored and presented recently by Ismael et al [31] Assessment of the cytotoxic and genotoxic potentials of Fe (II)-complexes with Trigonella photocatalytic processes was represented recently. [32] Some new Fe (III)-complexes was subjected as antidiabetic candidates, which assigned by Kumar et al [33] The antimicrobial potential of Mn (II), Co (II), Ni (II), Cu (II), and Zn (II) complexes of isatin Schiff base was recently studied by Swathy et al [34] and also of Cu (II), Co (II), Ni (II), and Cd (II) chelates of isatin derivatives was soon presented by El-Sonbati el al. [35] As α-glucosidase inhibitors, new category of metal-isatin based Schiff base complexes were published recently by Rahim et al [36] Depending on the literature survey, herein two pincer chelating tri-dentate isatin hydrazone salicylidene ligands (HLSO 3 Na and HLDBu) are coordinated ligands to iron (II) ions to award two various polar and nonpolar Fe (LSO 3 Na) 2 and Fe (LDBu) 2 complexes, respectively.…”

Synthesis, characterization, and investigation of some properties of the new symmetrical bisimine Ni(II), Zn(II), and Fe(III) complexes derived from the monoimine ligand

“…[15] In a study conducted in recent years, it has been explained that Fe(III) complexes developed from some salen derivatives show antidiabetic effect equivalent to metformin. [16] Ni(II)-salen complexes exhibit antimicrobial and DNAbinding activities and also play a key role as catalysts in the electroreductive cyclization and hydrogenation reactions. [17][18][19][20] Zn(II)-centered complexes are used to develop new materials with various photophysical, catalytic, and sensor properties.…”