Evaluation of Carotid Artery Atherosclerosis and Arterial Stiffness in Cardiovascular Disease Risk: An Ongoing Prospective Study From the Kailuan Cohort

Wen, Li; Wang, Yan; Chen, Shuohua; Zhao, Jian; Su, Qi; Fan, Yanfeng; Wu, Shouling; Li, Jun; Hong, Jiang

doi:10.3389/fcvm.2022.812652

Cited by 8 publications

(9 citation statements)

References 59 publications

(47 reference statements)

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“…The presence of carotid plaque has also been associated with an increased risk for MI or coronary events in most 9,13,28,34 but not all studies. 22,23,32 A pooled meta-analysis (Figure 1), using adjusted HRs from the individual studies, showed that carotid plaque presence was associated with both increased stroke risk (HR, 1.89 [95% CI, 1.04–3.44], P =0.04, I 2 =0.0%; 8 studies, n=23 792, including 12 635 women and 11 157 men) and with increased coronary heart disease-related events (HR, 1.77 [95% CI, 1.19–2.62], P =0.01, I 2 =0.0%; 7 studies, n=24 115, including 12 392 women and 11 723 men). An association with CVD was also detected, but this fell short of statistical significance (HR, 1.72 [95% CI, 0.84–3.52], P =0.08, I 2 =0.0%; 3 studies, n=13 054, including 6312 women and 6742 men).…”

Section: Methodsmentioning

confidence: 99%

“…Atherosclerosis-Related Clinical Events Some 8,9,12,[19][20][21] but not all 15,[22][23][24] of the large cohort studies that tested whether presence of carotid plaque confers increased stroke risk found a positive association (Table 2). The presence of carotid plaque has also been associated with an increased risk for MI or coronary events in most 9,13,28,34 but not all studies.…”

Section: Association Of Carotid Plaque Measurements Withmentioning

confidence: 99%

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Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies

Garg,

Bhatia,

Allen

et al. 2024

ATVB

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BACKGROUND: One strategy to reduce the burden of cardiovascular disease is the early detection and treatment of atherosclerosis. This has led to significant interest in studies of subclinical atherosclerosis, using different phenotypes, not all of which are accurate reflections of the presence of asymptomatic atherosclerotic plaques. The aim of part 2 of this series is to provide a review of the existing literature on purported measures of subclinical disease and recommendations concerning which tests may be appropriate in the prevention of incident cardiovascular disease. METHODS: We conducted a critical review of measurements used to infer the presence of subclinical atherosclerosis in the major conduit arteries and focused on the predictive value of these tests for future cardiovascular events, independent of conventional cardiovascular risk factors, in asymptomatic people. The emphasis was on studies with >10 000 person-years of follow-up, with meta-analysis of results reporting adjusted hazard ratios (HRs) with 95% CIs. The arterial territories were limited to carotid, coronary, aorta, and lower limb arteries. RESULTS: In the carotid arteries, the presence of plaque (8 studies) was independently associated with future stroke (pooled HR, 1.89 [1.04–3.44]) and cardiac events (7 studies), with a pooled HR, 1.77 (1.19–2.62). Increased coronary artery calcium (5 studies) was associated with the risk of coronary heart disease events, pooled HR, 1.54 (1.07–2.07) and increasing severity of calcification (by Agaston score) was associated with escalation of risk (13 studies). An ankle/brachial index (ABI) of <0.9, the pooled HR for cardiovascular death from 7 studies was 2.01 (1.43–2.81). There were insufficient studies of either, thoracic or aortic calcium, aortic diameter, or femoral plaque to synthesize the data based on consistent reporting of these measures. CONCLUSIONS: The presence of carotid plaque, coronary artery calcium, or abnormal ankle pressures seems to be a valid indicator of the presence of subclinical atherosclerosis and may be considered for use in biomarker, Mendelian randomization and similar studies.

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Section: Methodsmentioning

confidence: 99%

Section: Association Of Carotid Plaque Measurements Withmentioning

confidence: 99%

Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies

Garg,

Bhatia,

Allen

et al. 2024

ATVB

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“…As a result, arterial stiffness is associated with cerebral small‐vessel disease, cognitive decline, lower glomerular filtration rate 2 . Additionally, arterial stiffness is also considered as a predictor of cardiovascular disease and all‐cause mortality 3–5 …”

Section: Introductionmentioning

confidence: 99%

Development and validation of a nomogram for arterial stiffness

Wang,

Cai,

Zhang

et al. 2023

J of Clinical Hypertension

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Even though as a gold standard for noninvasive measurement of arterial stiffness, carotid‐femoral pulse wave velocity (cfPWV) is not widely used in primary healthcare institutions due to time‐consuming and unavailable equipment. The aim of this study was to develop a convenient and low‐cost nomogram model for arterial stiffness screening. A cross‐sectional study was undertaken in the department of general practice, the First Affiliated Hospital of Fujian Medical University. Arterial stiffness was defined as cfPWV ≥ 10 m/s. A total of 2717 participants were recruited to construct the nomogram using the least absolute shrinkage and selection operator and logistic regressions. Receiver operating characteristic (ROC) curve, calibration curve, decision curve analysis, clinical impact curve were used to evaluate the performance of the model. The model was validated internally and externally (399 participants) by bootstrap method. Arterial stiffness was identified in 913 participants (33.60%). Age, sex, waist to hip ratio, systolic blood pressure, duration of diabetes, heart rate were selected to construct the nomogram model. Good discrimination and accuracy were exhibited with area under curve of 0.820 (95% CI 0.803–0.837) in ROC curve and mean absolute error = 0.005 in calibration curve. A positive net benefit was shown in decision curve analysis and clinical impact curve. A satisfactory agreement was displayed in internal validation and external validation. The low cost and user‐friendly nomogram is suitable for arterial stiffness screening in primary healthcare institutions.

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“…Arterial stiffness, which can cause the formation of atherosclerotic plaques and eventually lead to the narrowing of blood vessels, is a major risk factor for CVD [ 5 ]. Early detection of vascular elasticity has important clinical significance for the prevention and treatment of cardiovascular events.…”

Section: Introductionmentioning

confidence: 99%

Use of the Vascular Overload Index to Predict Cardiovascular Disease in a Rural Population of China

Wang

Shi

Liu

et al. 2022

BioMed Research International

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Objective. To explore the relationship between vascular overload index (VOI) and cardiovascular disease (CVD) in rural population and find effective ways to prevent cardiovascular disease in rural low-income populations. Methods. The data for this study was obtained from a large cohort study called the Northeast China Rural Cardiovascular Health Study (NCRCHS) conducted in 2013 and followed up during 2015-2018. 10,174 subjects completed at least one follow-up visit. Cox regression equation was used to explore whether VOI and cardiovascular disease were independently related. The Kaplan-Meier curves were used to calculate the cumulative incidence of any adverse outcome, and the log-rank test and restrict mean survival analysis were used to compare group differences. Reclassification and discrimination statistics were used to determine whether VOI could strengthen the ability of the model to predict CVD events. Results. The prevalence of CVD in the VOI quartiles was 1.92%, 3.96%, 5.42%, and 11.34% for Q1–Q4, respectively ( P for trend <0.001). After adjusting for multiple confounders, there was a 2.466-fold increased risk of CVD when comparing the highest and lowest groups. Besides, this study found that for every standard deviation increase, the results still exist. The risk of cardiovascular disease increased by 1.358-fold in this model. The restrict mean survival analysis results show that with the increase of VOI, the restrict mean survival time (RMST) within 5 years gradually became shorter. Reclassification and discrimination statistics indicated that VOI significantly enhanced the ability to estimate CVD events within 4 years. Conclusion. Analyses showed that VOI was significantly associated with CVD. VOI is a simple and accurate prognostic marker of CVD risk, which has the potential ability to improve the risk stratification of CVD.

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Evaluation of Carotid Artery Atherosclerosis and Arterial Stiffness in Cardiovascular Disease Risk: An Ongoing Prospective Study From the Kailuan Cohort

Cited by 8 publications

References 59 publications

Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies

Assessment of Subclinical Atherosclerosis in Asymptomatic People In Vivo: Measurements Suitable for Biomarker and Mendelian Randomization Studies

Development and validation of a nomogram for arterial stiffness

Use of the Vascular Overload Index to Predict Cardiovascular Disease in a Rural Population of China

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