Evaluation of carotid arterial plaques after endarterectomy for Helicobacter pylori infection

Malnick, Stephen; Goland, Sorel; Kaftoury, Avinoam; Schwarz, Henry; Pasik, S; Mashiach, Aaron; Sthoeger, Zev

doi:10.1016/s0002-9149(99)00158-7

Cited by 21 publications

(13 citation statements)

References 18 publications

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“…The results of the studies investigating the presence of H. pylori in atherosclerotic plaques by PCR are conflicting. [22][23][24][25][26][27][28][29] In some of these studies, the presence of H. pylori could not be detected, [22][23][24][25][26] whereas in others the presence of H. pylori could be shown. 17,[27][28][29] Standardization problems related to PCR may have a role in the failure to detect H. pylori in atheroma plaques by the PCR method, as is the case for C. pneumoniae.…”

Section: Discussionmentioning

confidence: 99%

Detection of Chlamydia pneumoniae and Helicobacter pylori in atherosclerotic plaques of carotid artery by polymerase chain reaction

Kaplan

Yavuz

Çınar

et al. 2006

International Journal of Infectious Diseases

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Section: Discussionmentioning

confidence: 99%

Detection of Chlamydia pneumoniae and Helicobacter pylori in atherosclerotic plaques of carotid artery by polymerase chain reaction

Kaplan

Yavuz

Çınar

et al. 2006

International Journal of Infectious Diseases

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“…However, we have not been able to identify H. pylori in carotid atherosclerotic plaques [13] nor have other workers [14]. An in-vivo study of markers of early atherosclerosis (carotid intima-media thickness, presence of carotid stenosis and an increase in arterial stiffness) found a correlation with C. pneumoniae but not for H. pylori, CMV or HSV [27].…”

Section: Discussionmentioning

confidence: 73%

“…Helicobacter pylori has been found in human carotid atherosclerotic plaques by morphology, immunohistochemistry and polymerase chain reaction [11,12]. However, our group has not found evidence for H. pylori in carotid atherosclerotic plaques [13] nor has another group in coronary endatherectomy samples [14].…”

Section: Introductionmentioning

confidence: 76%

Helicobacter pylori infection is not related to restenosis following angioplasty

et al. 2011

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Chronic inflammation is thought to be important in the pathogenesis of atherosclerosis. Helicobacter pylori (H. pylori) is a common chronic infection of humans that has been definitely linked to peptic ulcer. The evidence implicating H. pylori with atherosclerosis is controversial. We decided to investigate an effect of H. pylori infection on the restenosis after coronary angioplasty. Ninety four patients who underwent PTCA and a subsequent repeat angiography were included in the study. The indications for angiography and repeat PTCA were determined by the attending cardiologist. H. pylori serology was determined by ELISA. Sixteen (17.2%) of the patients developed restenosis. Of these 16, 12 (75%) were H. pylori seropositive versus 44 (56.4%) of the 78 patients who did not develop restenosis, p = 0.13. There was no difference between the H. pylori positive and negative patients with respect to cholesterol level, hypertension, diabetes or peptic disease. There appears to be no relationship between H. pylori and the development of restenosis following PTCA.

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“…Malnick et al 48 detected no H pylori in carotid endarterectomy samples from 10 male patients. Blasi and colleagues 49,50 examined material from …”

Section: Discussionmentioning

confidence: 96%

“…It detected up to 0.1 pg DNA corresponding to Ϸ50 microorganisms. Malnick et al 48 used the 26-kDa species-specific antigen reported to have poor sensitivity; Blasi and colleagues 49,50 used the urease gene, which, in the same comparative study, was described to provide low sensitivity, which was probably due to sequence polymorphism. Using the urease A gene method, Akyön et al 51 recently reported PCR detection of H pylori DNA in 19.5% of atherosclerotic plaques.…”

Section: Ameriso Et Al Detection Of H Pylori In Carotid Plaque 387mentioning

confidence: 99%

Detection of Helicobacter pylori in Human Carotid Atherosclerotic Plaques

Ameriso

Fridman

Leiguarda

et al. 2001

Stroke

168

105

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Background and Purpose-Several lines of evidence point toward a relationship between infection and atherosclerotic vascular disease. Thus, infection and inflammation often precede ischemic neurological events. Transient alterations in coagulation and direct arterial invasion by certain microorganisms have been reported. Helicobacter pylori infection is the major cause of peptic ulcer disease and appears to be a risk factor for ischemic cerebrovascular disease. However, in contrast to other chronic infectious agents, H pylori has not been consistently isolated from atherosclerotic lesions. Methods-We investigated the presence of H pylori in 38 atherosclerotic plaques obtained at carotid endarterectomy by using morphological and immunohistochemical techniques and a highly sensitive polymerase chain reaction method. We performed immunohistochemical detection of intercellular adhesion molecule-1, a marker related to inflammatory cell response. We also examined 7 carotid arteries obtained at autopsy from subjects without carotid atherosclerosis. Results-H pylori DNA was found in 20 of 38 atherosclerotic plaques. Ten of the H pylori DNA-positive plaques also showed morphological and immunohistochemical evidence of H pylori infection. None of 7 normal carotid arteries was positive for H pylori. Intercellular adhesion molecule-1 was expressed in 75% of H pylori-positive plaques and in 22% of H pylori-negative plaques. The presence of the microorganism was associated with male sex but was independent of age, vascular risk factor profile, and prior neurological symptoms. Conclusions-H

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Evaluation of carotid arterial plaques after endarterectomy for Helicobacter pylori infection

Cited by 21 publications

References 18 publications

Detection of Chlamydia pneumoniae and Helicobacter pylori in atherosclerotic plaques of carotid artery by polymerase chain reaction

Detection of Chlamydia pneumoniae and Helicobacter pylori in atherosclerotic plaques of carotid artery by polymerase chain reaction

Helicobacter pylori infection is not related to restenosis following angioplasty

Detection of Helicobacter pylori in Human Carotid Atherosclerotic Plaques

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