Detection of Chlamydia pneumoniae and Helicobacter pylori in atherosclerotic plaques of carotid artery by polymerase chain reaction

Kaplan, Mehmet; Yavuz, Serap Şimşek; Çınar, Bayer; Köksal, Vedat; Kut, Mustafa Sinan; Yapıcı, Fikri; Gerçekoğlu, Hakan; Demirtaş, Mahmut Murat

doi:10.1016/j.ijid.2004.10.008

Cited by 67 publications

(47 citation statements)

References 27 publications

(22 reference statements)

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“…Some trials demonstrated that HP infection may have a role in the development of atherosclerosis and may be a risk factor for CAD but some did not [5][6][7][8][9]. In the present study, we confirmed the presence of a significant association between HP infection and angiographically confirmed CAD.…”

Section: Discussionsupporting

confidence: 85%

Helicobacter pylori Seropositivity in Patients with Acute Coronary Syndromes

et al. 2008

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The aim of this study was to investigate the seroprevalence of Helicobacter pylori (HP) in patients with coronary atherosclerosis and acute coronary syndromes. We enrolled 152 patients (group I, 73 patients with acute coronary syndrome; group II, 79 patients with chronic stable angina) and 22 control subjects. An enzyme-linked immunosorbent assay for immunoglobulin (Ig) G test for HP diagnosis was used on all enrolled subjects. C-reactive protein (CRP) was also measured in all patients as an inflammatory marker. Seropositivity rates for HP were significantly higher in patients with coronary artery disease than in controls (80.2% versus 54.5%; P < 0.05). Although CRP level was significantly higher in group I than in group II (1.72 +/- 2.89 mg/dl versus 0.53 +/- 0.63 mg/dl, P < 0.0001), HP infection rates were similar between groups (86.3% versus 74.6%, P > 0.05). Infection with HP may influence atherogenesis through low-grade, persistent inflammatory stimulation. However, our data show evidence of increased systemic inflammation in patients with acute coronary syndrome, which was unrelated to an increased HP seropositivity.

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Section: Discussionsupporting

confidence: 85%

Helicobacter pylori Seropositivity in Patients with Acute Coronary Syndromes

et al. 2008

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“…20 In 52 specimens from macroscopically healthy regions of the wall of the ascending aorta, there was 1 case (1.9%) of C. pneumoniae and none of the samples obtained from the same patients were positive for H. pylori. 21 Other investigations have not confirmed this difference in the frequency of pathogens DNA in the atheromatous and healthy aorta. In our recent study of samples of non-atherosclerotic aorta from CAD patients, we found Data are mean ± SD or percent.…”

Section: Discussionmentioning

confidence: 92%

Mycotic DNA in Non-Atherosclerotic Aortic Wall of Coronary Patients Is Associated With sICAM-1 Expression

Jegier

Jaszewski

Kurnatowski

et al. 2010

Circ J

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“…In this study, 10 formalin-fixed atherosclerotic coronary arteries obtained from autopsy were examined using electron microscopy, and C. pneumoniae-like organisms were visualized in all cases, located in the lipid-rich core of plaques and within smooth muscle cells (SMCs). Since then, multiple studies have confirmed the presence of this bacterium in various atherosclerotic arteries [15][16][17][18][19][20], whereas others did not [21][22][23]. In 1996, viable C. pneumoniae was cultured from a coronary artery [24],…”

Section: Chlamydia Pneumoniaementioning

confidence: 99%