Evidence for a vascular microbiome and its role in vessel health and disease

Clifford, Alison; Hoffman, Gary S.

doi:10.1097/bor.0000000000000184

Cited by 36 publications

(33 citation statements)

References 73 publications

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“…Lastly, the possibility of a vascular microbiome is emerging as studies now refute the idea that blood vessels are sterile 26. Perturbances in the vascular microbiome from infections and/or antimicrobial therapy may increase susceptibility to GCA, although no studies have yet demonstrated this directly 3 27 28…”

Section: Discussionmentioning

confidence: 99%

Infections and the risk of incident giant cell arteritis: a population-based, case-control study

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Infections and the risk of incident giant cell arteritis: a population-based, case-control study

et al. 2016

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“…Synergistic in vivo and in vitro “ pan - microbiome ” studies in various mucosal sites, including extra-colonic microbiome in the oral cavity, nasopharynx, respiratory tract, genital tract, bladder, skin, and also a vascular microbiome (as blood vessels may not be sterile and vascular microbial communities are related to noninflammatory and inflammatory vessel diseases [ 113 ]), microbiome in childhood, ageing and pregnancy [ 114 ], particularly in genetically predisposed individuals and tailored for each gender is promising for discovery potential biomarkers of chronic diseases and may provide important insights into disease pathogenesis and suggest new therapies.…”

Section: Discussionmentioning

confidence: 99%

Probiotics and immunity: provisional role for personalized diets and disease prevention

et al. 2015

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There is great interest in the interaction between diet and immune system and concomitantly in the potential of probiotic bacteria, especially given recent advances in understanding of gut microbiota effects on health in the context of microbiome research. Following our recent study on bacterial wall elasticity as a predictive measure of phagocytic cellular reactions and related outcomes, a question was raised regarding the scope of the application of these findings in various medical conditions in the context of predictive, preventive, and personalized medicine (PPPM). This summarizing review of the data describes the contributions, both observed and potential, of probiotics to the gut-brain axis and various medical conditions, including immune and atopic states, metabolic and inflammatory diseases—including liver disease and diabetes mellitus—cancer, and more. It also suggests novel insights for a number of beneficial applications of probiotics and advances in development of novel probiotic-based treatments and personalized diets, as well as application of sophisticated imaging techniques and nanobiotechnologies that can be adopted in the near future by innovative medical experts, warranting further research and practical translation.

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“…For example, intestinal colonization with Oxalobacter formigenes, which degrades oxalate, is associated with lower urine oxalate levels and fewer recurrent stones; though a protective effect of exogenous Oxalobacter remains unconfirmed (19). Emerging evidence indicates that bacteria are present in and contribute to vascular calcifications (20,21). Therefore, it is possible that bacteria also are present in and contribute to urinary calcifications.…”

Section: Usd Relevance Of the Microbiotamentioning

confidence: 99%

The association between bacteria and urinary stones

Schwaderer

Wolfe

2017

Ann. Transl. Med.

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Urinary stone disease (USD) is an increasing clinical problem in both children and adults. One in ten individuals will experience a urinary stone, yet the mechanisms responsible for urinary stones remain largely unknown. Bacteria have long been recognized to contribute to struvite urinary stones; however, the role of bacteria in the development of the more common calcium oxalate (CaOx) and calcium phosphate (CaPhos) stones has not been extensively investigated. However, several findings do indicate a possible association between urinary stones and bacteria, including the high rate of urinary tract infections (UTI) in urinary stone patients and multiple case series of culture-positive urinary stones, including stones composed of CaOx or CaPhos. New technology, such as next generation sequencing, may be used to lend additional insight regarding the association between urinary stones and bacteria. In 2015, we published the initial bacterial sequencing results from five urinary stones, from which we sequenced multiple types of bacterial DNA. Whether these bacteria are causal, disease modifying or passively present remains to be determined. However, initial exploration of underlying mechanisms for this association indicate that bacteria aggregate selectively to crystals, that their presence is associated with increased clumping of crystals, and that they stimulate incorporation of proteins into the stone matrix.

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Evidence for a vascular microbiome and its role in vessel health and disease

Abstract: Blood vessels may not be sterile. Future studies of microbes in vessel health and disease may provide important insights into disease pathogenesis and suggest new therapies for diseases now considered to be idiopathic and refractory.

Cited by 36 publications

References 73 publications

Infections and the risk of incident giant cell arteritis: a population-based, case-control study

Infections and the risk of incident giant cell arteritis: a population-based, case-control study

Probiotics and immunity: provisional role for personalized diets and disease prevention

The association between bacteria and urinary stones

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