Evaluation of cadmium, lead, nickel and zinc status in biological samples of smokers and nonsmokers hypertensive patients

Afridi, Hassan Imran; Kazi, Tasneem Gul; Kazi, Naveed; Jamali, Mohammad Khan; Arain, Mohammad Balal; Sirajuddin, Sirajuddin; Baig, Jameel Ahmed; Kandhro, Ghulam Abbas; Wadhwa, Sham Kumar; Shah, Abdul Qadir

doi:10.1038/jhh.2009.39

Cited by 104 publications

(60 citation statements)

References 49 publications

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“…1B). Contrary to our results, Kazi et al 15) reported higher levels of Fe in the scalp hair of diabetic subjects than in control subjects with lower levels of Fe excretion in the urine of diabetic subjects, and the lower levels of Mn in the hair of diabetic subjects than in control subjects. The reasons for this discrepancy remain open at the present.…”

Section: Discussioncontrasting

confidence: 55%

“…[25][26][27][28] However, only limited information is available on the age-and gender-related differences in the elements in the scalp hair of diabetic subjects. 10,15) Furthermore, renal disorders and hypertension, which are most common complications associated with diabetes, affect the levels of elements in the hair of diabetic subjects. [14][15][16]29) Detail studies focused on age and gender, in addition to the renal disorders and hypertension, are necessary to elucidate fully the changes in the concentrations of element in the scalp hair.…”

Section: Discussionmentioning

confidence: 99%

“…However, some data for Mn and Mg previously reported in relation to diabetic subjects were controversial, 1) and nephropathy and hypertension, which are common complications of diabetes, affect the level of trace elements in the scalp hair. 8,[14][15][16] There is no report on the correlation between HbA1c and the concentrations of essential and toxic metals in the scalp hair so far. In the present study, we investigate the relationships between HbA1c and the concentrations of 12 elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn, V, As, Cd, Hg and Pb) in the scalp hair and between HbA1c and eGFR of diabetic patients in Japan.…”

mentioning

confidence: 99%

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Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Hotta

Fujino

Kimura

et al. 2018

Biological & Pharmaceutical Bulletin

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Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glycated hemoglobin (HbA1c) ranging between 6.2 and 14.4%. The levels of Zn, Cu and Cr in the diabetic subjects (HbA1c>7) were significantly lower than those in the control subjects (p<0.05), and these concentrations decreased significantly with increases in HbA1c (p<0.01). The levels of Fe and Mg in the diabetic subjects were insignificantly lower, and the concentration of Fe decreased significantly with increases in HbA1c (p<0.05) and the concentration of Mn tended to decrease (p<0.10). In contrast, the concentration of As tended to increase with increases in HbA1c ( p<0.10). The concentrations of other elements, such as Ca, Mn, V, Pb, Cd and Hg, in the diabetic subjects were similar to those of control subjects, and did not correlate with HbA1c. The average of estimated glomerular filtration rate (eGFR) in the diabetic subjects was 77.7 29.7 mL/min/1.73 m 2 with large variation (12.7-148 mL/min/1.73 m 2 ), and previous study reported the increase of urinary excretion of Zn, Cr, Mn and Mg in diabetic subjects. The decreases of Zn, Cu, Cr, Fe and Mg concentrations in hair may reflect increased urinary excretion of these elements due to diabetic nephropathy.Key words diabetes; scalp hair; glycated hemoglobin (HbA1c); zinc; chromium; copper Diabetes mellitus is a serious and chronic metabolic disorder. Type 2 diabetes results from a disruption in glucose metabolism associated with a reduction in insulin production and utilization by tissues. Glycated hemoglobin (HbA1c) levels are used for screening and diagnostic purposes as HbA1c indicates the quality of blood glucose control over the previous 1-2 or 2-3 months. A HbA1c (%) value greater than 6.5 is a cut-off point for diabetic subjects and is highly prognostic for longterm diabetes-related complications such as nephropathy, retinopathy and neuropathy, and maintenance of the HbA1c value below 7.0 is a therapeutic guideline for the prevention of such complications of the Japan Diabetic Society. Estimated glomerular filtration rate (eGFR) is used for screening for nephropathy. The glomerular filtration rate (GFR) generally decreases as diabetes progresses, but the early stage of diabetic nephropathy is characterized by hyperfiltration (increase of GFR). 1) Deficiencies in trace elements such as Cr, Zn, Cu, Mg and Mn have been shown to predispose a person to glucose tolerance and to promote the development of diabetic complications. 2,3) Insulin resistance (IR) is defined as the condition in which insulin sensitive tissues become numb to insulin reception, and a Cr deficiency can induce IR. 2) Zn is known to synthesize insulin as well as stabilize insulin that has been stored in the beta cells of the pancreas. 4) Further, Zn has an important role in the sec...

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Section: Discussioncontrasting

confidence: 55%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Hotta

Fujino

Kimura

et al. 2018

Biological & Pharmaceutical Bulletin

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“…It is observed that contents of lead (7)(8)(9) and arsenic (10-12) in biological samples of human population are much higher in smokers than those in non-smokers.…”

Section: Introductionmentioning

confidence: 97%

Determination of Lead and Arsenic in Tobacco and Cigarettes: an Important Issue of Public Health

Lazarević¹,

Nikolić²,

Stošić³

et al. 2012

Cent Eur J Public Health

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SUMMARYContents of lead and arsenic were determined in 617 tobacco samples and 80 samples of cigarettes. The mean content of lead in tobacco was 0.93 μg/g (range 0.02-8.56 μg/g) and arsenic was 0.15 μg/g (range <0.02-2.04 μg/g). The mean content of lead in cigarettes was 1.26 μg/g (range 0.02-6.72 μg/g) and arsenic was 0.11 μg/g (range <0.02-0.71 μg/g). There was a large variability in lead and arsenic content among samples of tobacco and samples of cigarettes. Positive correlation between lead and arsenic contents in tobacco was found (r=0.22; p<0.0001).Based on our data and data from literature we compare the content of lead and arsenic in tobacco and cigarettes in other studies and discuss the influence of smoking to lead and arsenic exposure and health.In conclusion, at the same time with the implementation of tobacco use prevention programmes it is advisable to implement continuous monitoring of lead and arsenic in tobacco and cigarettes in order to reduce the health risk due to exposure of these metals.

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“…Recently, Kasperczyk et al, [29] found that B-Pb levels were positively correlated with high arterial blood pressure (both systolic and diastolic). Moreover, Afridi et al, [30] reported higher levels of B-Pb as well as a lower level of Zn, correlated well with the consequences of hypertension. Conversely, Staessen et al, [31] failed to recognize a significant relation between B-Pb and hypertension.…”

Section: Discussionmentioning

confidence: 99%

Relationship Between Blood Lead Level and Elevated Blood Pressure in Hypertensive Patients: Implication of Nitric Oxide

Meki¹

2011

TONOJ

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Abstract:The correlation between the blood lead (B-Pb ) levels and the values of blood pressure in hypertensive patients was investigated. Moreover, plasma levels of nitric oxide (NO), total antioxidants (TAOX) and malondialdehyde (MDA) were detected to investigate the correlations between the measured parameters and B-Pb levels in hypertensive patients. Fifty-five hypertensive patients were compared with fifty-three age and sex matched control group. The B-Pb levels were detected by flame atomic absorption spectrometry. The plasma levels of NO, TAOX and MDA were measured by colorimetric methods. In the hypertensive patients, B-Pb levels were significantly higher than controls. Concomitantly, the plasma levels of MDA were significantly increased while the plasma levels of NO and TAOX were significantly reduced in the hypertensive patients in comparison with controls. There were significant positive correlations between B-Pb and each of MDA, systolic and diastolic blood pressure. Conversely, a significant negative correlation was found between BPb and NO. Our study indicated that B-Pb level was associated with elevated blood pressure as well as oxidative stress in hypertensive patients. Moreover, the negative correlation between the B-Pb level and NO level may clarify their implication in cardiovascular disease and hypertension.

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Evaluation of cadmium, lead, nickel and zinc status in biological samples of smokers and nonsmokers hypertensive patients

Cited by 104 publications

References 49 publications

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Determination of Lead and Arsenic in Tobacco and Cigarettes: an Important Issue of Public Health

Relationship Between Blood Lead Level and Elevated Blood Pressure in Hypertensive Patients: Implication of Nitric Oxide

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