Evaluation of Breath-Holding Test in Assessment of Peripheral Chemoreflex Sensitivity in Patients with Chronic Heart Failure

Трембач, Н. В.; Zabolotskikh, I.B.

doi:10.2174/1874306401711010067

Cited by 8 publications

(7 citation statements)

References 22 publications

(31 reference statements)

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“…The study correlated well with breath holding with post bronchodilator (26,27), forced expiratory volume (FEV) [28], forced vital capacity (FVC) [29], peak expiratory flow rate (PEFR) is normal which was similar to the findings observed in the current study [25,30]. Mariappan et al conducted a study on the effect of physical training among Indian people (31), it enhances the respiratory efficiency by increasing the strength of diaphragm and intercostal muscles which were similar to the findings that male have more breath holding time than females in this study [32].…”

Section: Discussionsupporting

confidence: 87%

“…By comparing the previous studies which are done similar to the present study [1], the breath holding spells of pediatrics have more significance towards breath holding capacity in children [24]. Then the evaluation of breath holding tests for peripheral chemoreflex sensitivity in patients was performed and also about the chronic heart failure [25].…”

Section: Discussionmentioning

confidence: 68%

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Estimation of Breath Holding Time (BHT) among Dental Students

Mohamed

Devi

Priya

2021

JPRI

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Background: Breath holding time is the time taken by an individual to hold his/her breath as long as they can. During voluntary breath holding, tissues continue to utilize oxygen and liberate carbon dioxide. Therefore, during breath holding arterial pO2 falls and pCO2 rises. Normal Breath holding time (BHT) is 45-55 seconds which is estimated at 2014. The main aim of this study is to assess the breath holding time among healthy dental students. Materials and Methods: A minimal number of sample sizes have been taken into account with regards to their BMI. The sample size was divided into two groups as gender comparison. Students were detail explained about the procedure and breath holding time has been measured. The statistical analysis was done by ANOVA test in SPSS Software-23 and an independent t-test was calculated. Results: BHT was found to be significantly low among females compared to males. A statistically significant negative correlation was observed when BHT is correlated with gender because BHT differs in both the gender. Conclusion: The present study revealed that breath holding time is less in females compared to males. Therefore, males are healthier than females.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 68%

Estimation of Breath Holding Time (BHT) among Dental Students

Mohamed

Devi

Priya

2021

JPRI

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“…The breath-hold manoeuvre was performed two to three times with ≥ 5 min pause between consecutive runs and the average duration of the voluntary apnoea was taken as a measure of PCheS (BHT apnoea duration, s). Several papers reported high agreement between BHT and single-breath CO 2 method for PCheS evaluation in healthy subjects 29 , 31 and heart failure patients 30 , however to the authors’ knowledge, the agreement between BHT and the transient hypoxia test has not yet been investigated.…”

Section: Methodsmentioning

confidence: 89%

“…However, due to technical difficulties, it cannot be performed in the field. Therefore, a novel promising, yet not fully established method, the breath-holding test 29 , 30 has been used to assess the PCheS before and after the race, in addition to the transient hypoxia testing carried out before the race only.…”

Section: Methodsmentioning

confidence: 99%

Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men

Paleczny

Seredyński

Wyciszkiewicz

et al. 2021

Sci Rep

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The aim of this study was to test the utility of haemodynamic and autonomic variables (e.g. peripheral chemoreflex sensitivity [PCheS], blood pressure variability [BPV]) for the prediction of individual performance (marathon time and VO2max) in older men. The post-competition vasodilation and sympathetic vasomotor tone predict the marathon performance in younger men, but their prognostic relevance in older men remains unknown. The peripheral chemoreflex restrains exercise-induced vasodilation via sympathetically-mediated mechanism, what makes it a plausible candidate for the individual performance marker. 23 men aged ≥ 50 year competing in the Wroclaw Marathon underwent an evaluation of: resting haemodynamic parameters, PCheS with two methods: transient hypoxia and breath-holding test (BHT), cardiac barosensitivity, heart rate variability (HRV) and BPV, plasma renin and aldosterone, VO2max in a cardiopulmonary exercise test (CPET). All tests were conducted twice: before and after the race, except for transient hypoxia and CPET which were performed once, before the race. Fast marathon performance and high VO2max were correlated with: low ventilatory responsiveness to hypoxia (r = − 0.53, r = 0.67, respectively) and pre-race BHT (r = − 0.47, r = 0.51, respectively), (1) greater SD of beat-to-beat SBP (all p < 0.05). Fast performance was related with an enhanced pre-race vascular response to BHT (r = − 0.59, p = 0.005). The variables found by other studies to predict the marathon performance in younger men: post-competition vasodilation, sympathetic vasomotor tone (LF-BPV) and HRV were not associated with the individual performance in our population. The results suggest that PCheS (ventilatory response) predicts individual performance (marathon time and VO2max) in men aged ≥ 50 yeat. Although cause-effect relationship including the role of peripheral chemoreceptors in restraining the post-competition vasodilation via the sympathetic vasoconstrictor outflow may be hypothesized to underline these findings, the lack of correlation between individual performance and both, the post-competition vasodilation and the sympathetic vasomotor tone argues against such explanation. Vascular responsiveness to breath-holding appears to be of certain value for predicting individual performance in this population, however.

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“…Unfortunately, the authors of the method do not give the quantitative indices of the norm and pathology of chemoreceptor sensitivity necessary to solve the question of the patient readiness for being weaned from the ventilator. Zabolotsky and Trembach [ 7 ] proposed a simple and effective method for assessing PCSI. According to different durations of induced threshold apnea, a different degree of peripheral chemoreflex sensitivity is determined.…”

Section: Discussionmentioning

confidence: 99%

Prediction of the Effectiveness of Spontaneous Breathing in Patients with Brain Damage of Various Etiologies

et al. 2020

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The aim of the study was to develop an informative method for assessing chemoreflex sensitivity and to evaluate its prognostic capacity for restoring spontaneous breathing in patients with brain damage of various etiologies. The study included 16 healthy volunteers and 38 patients on prolonged mechanical ventilation (VE) after a traumatic brain injury, anoxic brain damage, and cerebrovascular events. The external respiration variables were assessed from the initial level to the development of the first episode of desaturation with spO 2 in the range of 90-80% against the background of normobaric hypoxia as indicators reflecting the development of adaptive ventilatory response and characterizing the state of peripheral chemoreflex sensitivity (PCS). The peripheral chemoreflex sensitivity index (PCSI) was calculated using the equation: PCSI = [RR(e) : RR(i)] × [Vt(e) : Vt(i)] × [VE(e) : VE(i)] × Vt(e) × VE(e), where PCSI is the peripheral chemoreflex sensitivity index in L 2 /min; RR(i) and RR(e); Vt(i) and Vt(e); VE(i) and VE(e) are the respiratory rate, tidal volume, minute ventilation initially (i), before a functional stress test, and during a functional test of normobaric hypoxia with spO 2 in the range of 90-80% (e). With the PCSI values ≥15.6 L 2 /min, successful weaning from ventilators and recovery of spontaneous breathing are predicted. The sensitivity and specificity of PCSI were 78.57 [95% CI: 49.2-95.26] and 83.3% [95% CI: 62.6-95.26], respectively. The sensitivity and specificity of the traditional indicator of the success rate of weaning from ventilators and recovery of spontaneous breathing, Rapid Shallow Breathing Index (RSBI), in this cohort of patients was 69.23 [95% CI: 38.6-90.9] and 28.0% [95% CI: 12.03-49.3], respectively. A predictor of the patient's weaning from mechanical ventilation is the assessment of peripheral chemoreflex sensitivity, which can be measured by a simple non-invasive bedside test based on measuring the difference in external ventilation parameters before and during a functional normobaric hypoxic trial.

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Evaluation of Breath-Holding Test in Assessment of Peripheral Chemoreflex Sensitivity in Patients with Chronic Heart Failure

Cited by 8 publications

References 22 publications

Estimation of Breath Holding Time (BHT) among Dental Students

Estimation of Breath Holding Time (BHT) among Dental Students

Low ventilatory responsiveness to transient hypoxia or breath-holding predicts fast marathon performance in healthy middle-aged and older men

Prediction of the Effectiveness of Spontaneous Breathing in Patients with Brain Damage of Various Etiologies

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