Evaluation of Boneloc®: Chemical and mechanical properties, and a randomized clinical study of 30 total hip arthroplasties

Thanner, Jonas; Freij-Larsson, Christina; Kärrholm, Johan; Malchau, Henrik; Wesslén, Bengt

doi:10.3109/17453679508995525

Cited by 95 publications

(50 citation statements)

References 23 publications

(19 reference statements)

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“…Our results are similar to those of Thanner et al (1995) in total hip replacements, the difference being that statistical significance was obtained earlier in the total hips. Thanner et al (1995) showed that Boneloc had reduced tensile strength and increased elasticity compared to Palacos.…”

Section: Discussionsupporting

confidence: 80%

“…We believe that the large initial migration of the tibial components in our study was caused by insufficient strength or increased deformation of the cement. Thanner et al (1995) also found that, due to its lower glass transition temperature, Boneloc released larger amounts of monomers to the interface. This could lead to increased bone resorp-tion at the interface, causing progressive radiolucency and accelerating subsidence.…”

Section: Discussionmentioning

confidence: 99%

“…Thanner et al (1995) showed that Boneloc had reduced tensile strength and increased elasticity compared to Palacos. We believe that the large initial migration of the tibial components in our study was caused by insufficient strength or increased deformation of the cement.…”

Section: Discussionmentioning

confidence: 99%

“…However, Boneloc soon turned out to be a failure in total hip arthroplasty. In a RSA study, total hips fixed with Boneloc migrated more than those with conventional bone cement within only a few months postoperatively (Thanner et al 1995). Several clinical reports on high revision rates of total hip arthroplasty during 1995 led to its withdrawal from the market during the summer of 1995 (Havelin et al 1995, Linder 1995, Riegels-Nielsen et al 1995, Suominen 1995.…”

mentioning

confidence: 99%

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Inferior performance of Boneloc® bone cement in total knee arthroplasty: A prospective randomized study comparing Boneloc® with Palacos® using radiostereometry (RSA) in 19 patients

Nilsson

Dalén

1998

Acta Orthopaedica Scandinavica

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We compared Boneloc@ bone cement with conventional cement (Palaces@) in fixating the tibial component during 2-5 years in 19 patients with gonarthrosis undergoing total knee arthroplasty in a prospective randomized study. Boneloc displayed significantly larger migration, subsidence and lift-off than Palacos. The difference was identifiable already within 3 months postoperatively, but became significant at 12 months. In the Boneloc group, all components showed subsidence of the posterior part and lift-off of the anterior part of the tibial component, whereas in the Palacos group, the locations of subsidence and lift-off were evenly distributed about the edge of the implant. At 5 years, both Boneloc knees so far investigated were clinical failures with high migration rates. We conclude that, even in total knee arthroplasty, there is a substantial risk that Boneloc leads to inferior clinical results, but later than in hip replacements.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Inferior performance of Boneloc® bone cement in total knee arthroplasty: A prospective randomized study comparing Boneloc® with Palacos® using radiostereometry (RSA) in 19 patients

Nilsson

Dalén

1998

Acta Orthopaedica Scandinavica

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“…The clinical performance of the original Spectron stem was good [6]. Thanner et al [23] demonstrated close to zero subsidence for the second generation of Spectron stems (Spectron EF) when used with Palacos 1 cement (Heraeus, Hanau, Germany). The mean subsidence at 1 and 2 years were À0.03 and À0.06 mm, which is less than half the values recorded in the present study (À0.08 and À0.014 mm).…”

Section: Discussionmentioning

confidence: 99%

Early Subsidence Predicts Failure of a Cemented Femoral Stem With Minor Design Changes

Johanson

Antonsson

Shareghi

et al. 2016

Clinical Orthopaedics &Amp; Related Research

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Background Radiostereometry (RSA) measurements of early micromotion can predict later failure in hip and knee prostheses. In hip implants, RSA has been particularly helpful in the evaluation of composite-beam stem designs. The Spectron EF Primary stem (Smith & Nephew, London, UK) has shown inferior performance compared with its predecessors in both clinical studies and registry reports. Early RSA studies have shown somewhat greater subsidence for the Spectron EF Primary stem compared with the earlier Spectron EF, but still within boundaries considered to be safe.Questions/purposes Our primary research question was whether stem subsidence and rotation for this stem design measured with RSA at 2 years can predict later stem failure. A secondary question was whether high femoral stem offset and small stem sizes, both features specific to the Spectron EF Primary stem compared with its predecessors, are associated with stem failure rate. Methods Two hundred forty-seven hips (209 patients with median age 63 years [range, 29-80 years], 65% female, and 77% primary osteoarthritis) with a valid RSA examination at 2 years were selected from four different RSA studies (totaling 279 hips in 236 patients) in our department. The studies were primarily aimed at evaluating cup fixation, bone cement, and polyethylene types. All study patients received a cemented Spectron EF Primary stem. The selected hips had complete followup until stem failure, death, or the end of the followup period. Stem failure was defined as revision of a loose femoral stem or radiological failure with significant osteolysis in Gruen zones 2 to 6. Cox regression analyses were performed to evaluate if stem subsidence and rotation after 2 years, adjusted for age, sex, stem size, standard/high stem offset, and conventional/highly crosslinked polyethylene, could predict later clinical aseptic failure of the stem. We identified 32 stem failures (27 revisions, five radiological failures) at 14 years median followup (range, 3-18 years). Ten-year stem survival was 94% (95% confidence interval [CI], 90%-96%).Results Stem subsidence at 2 years (adjusted hazard ratio [HR], 6.0; 95% CI, 2.5-15; p \ 0.001) and retrotorsion of the stem (adjusted HR, 1.7; 95% CI, 1.1-2.5; p = 0.018) were associated with later stem failure. Further risk factors were male sex (subsidence analysis HR, 6.9; p [ 0.001), use of the two smallest stem sizes (HR size 1 , 8.0; p[0.001,

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Integrated system for preparation of bone cement and effects on cement quality and environment

Müller‐Wille

Wang

Lidgren

1997

J. Biomed. Mater. Res.

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We developed a prepacked mixing system for the preparation of bone cement. The system is based on mixing and collection of bone cement under a vacuum and serves as both the storage and mixing device for the cement components, thereby minimizing the exposure of the operating staff to the monomer and the risk for contamination of the cement during preparation. We evaluated the system using Palacos R and Simplex P. The cement produced was compared with cement obtained from a commercially available mixing system. Temperature evolution during curing, handling characteristics, density, and porosity of the cement obtained were analyzed. The results showed that the experimental system produces cement with physical properties (i.e., setting times and temperature, porosity, and density) equal to or better than those obtained with commercially available systems. Reducing the amount of monomer in the experimental system led to a reduction of the curing temperature without compromising the physical properties of the cements.

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Evaluation of Boneloc®: Chemical and mechanical properties, and a randomized clinical study of 30 total hip arthroplasties

Cited by 95 publications

References 23 publications

Inferior performance of Boneloc® bone cement in total knee arthroplasty: A prospective randomized study comparing Boneloc® with Palacos® using radiostereometry (RSA) in 19 patients

Inferior performance of Boneloc® bone cement in total knee arthroplasty: A prospective randomized study comparing Boneloc® with Palacos® using radiostereometry (RSA) in 19 patients

Early Subsidence Predicts Failure of a Cemented Femoral Stem With Minor Design Changes

Integrated system for preparation of bone cement and effects on cement quality and environment

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