Evaluation of bone mineral density and its associated factors in postpartum women

Eroğlu, Semra; Karataş, Gülşah; Aziz, Vusale; Gursoy, Aybala Fatma; Özel, Şule; Gülerman, Hacer Cavidan

doi:10.1016/j.tjog.2019.09.013

Cited by 9 publications

(3 citation statements)

References 28 publications

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“…Interesting results were reported by Eroglu et al [45] in a study of women with postpartum osteoporosis they found that NLR and PLR were lower in the low BMD group, but the differences were not significant. These results suggest that inflammation is not a key factor in every case of osteoporosis.…”

Section: Discussionmentioning

confidence: 85%

The relationship of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with bone mineral density in adolescent girls suffering from anorexia nervosa

Morawiecka-Pietrzak

Malczyk

Dąbrowska

et al. 2021

Endokrynologia Polska

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Introduction: Inflammation is supposed to be one of the factors contributing to decreased bone mineral density (BMD) in anorexia nervosa (AN). The neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) are simple and cost-effective inflammatory markers, well documented as indicators of postmenopausal osteoporosis. This study aimed to assess the relationships between these ratios and BMD in girls with AN. Material and methods:The electronic records of 73 girls hospitalized for AN were analysed retrospectively. The age range of the study group was 12.56-17.67 years. BMD was assessed by dual-energy X-ray absorptiometry (DXA) and expressed as Z-scores according to lumbar spine (s-BMD) and total body (TB-BMD) sites. NLR and PLR were calculated according to complete blood count results. Patients were divided into 2 subgroups with parallel analysesaccording to the TB-BMD criterion and the s-BMD criterion: normal (Z-score > -2.0, n = 63) and low s-BMD subgroup (Z-score ≤ -2.0, n = 10), and normal (Z-score > -2.0, n = 45) and low TB-BMD subgroup (Z-score ≤ -2.0, n = 28).Results: In the low s-BMD subgroup a tendency to an increase of mean NLR, PLR, and WBC values was observed. Respective BMD Z-score values correlated significantly and negatively with PLR in the low s-BMD (R = -0.892, p < 0.001) and normal TB-BMD (R = -0.451, p = 0.002) subgroups, while with NLR only in the normal TB-BMD subgroup (R = -0.685, p < 0.001). In the low s-BMD subgroup the PLR was shown to be a significant and independent predictor of s-BMD (β = -0.881, p < 0.001). The PLR contributed to 77.6% of the s-BMD Z-score variability (R 2 = 0.776, p < 0.001). In the normal TB-BMD subgroup, the PLR and NLR levels were significant and independent predictors of TB-BMD (β = -0.352, p = 0.004; β = -0.450, p = 0.001; β = -0.339, p = 0.005, respectively) and explained 44.4% of TB-BMD Z-score variability (R 2 = 0.444, p < 0.001). Conclusions:These results indicate that there might be a relationship between bone mass loss and inflammation expressed as NLR and PLR in adolescent girls suffering from AN. These connections seem to be dependent on the examined skeletal area. NLR and PLR, which are common indicators of morbidity and mortality in many malignancies and inflammatory chronic diseases, can also be useful in the evaluation of bone condition in adolescent females with AN. However, there is a need for further investigation in this field.

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Section: Discussionmentioning

confidence: 85%

The relationship of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with bone mineral density in adolescent girls suffering from anorexia nervosa

Morawiecka-Pietrzak

Malczyk

Dąbrowska

et al. 2021

Endokrynologia Polska

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“…It can cause severe loss of bone mineral density, pathological fractures in the vertebrae, hip and other bones. In the study of Eroglu et al, the levels of 25(OH)D3, in postpartum women, were significantly lower in the low Bone Mineral Density group [45].…”

Section: Vd3 During Lactation Ad Postpartum Periodmentioning

confidence: 84%

Vitamin D3 and its receptor in selected obstetrical complications

et al. 2021

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Vitamin D3 (VD3) and its steroidal nuclear receptor are necessary for proper development of a pregnancy. They play a key role in implantation, modulate the mother's immune response to the developing fetus, influence the final development of a placenta, and regulate blood pressure and glucose tolerance. VD3 deficiency can lead to the occurrence of obstetric complications such as recurrent miscarriages, preeclampsia, intrauterine growth restriction, gestational diabetes and preterm labor. VD3 deficiency is a common phenomenon across the globe; because of the higher demand placed on their bodies, pregnant women are more likely to develop VD3 deficiency. During pregnancy, VD3 supplementation is a safe method of treatment without risk of side effects or intoxication. To obtain the greatest efficacy, VD3 supplementation should start at the pregnancy planning stage, under control of the VD3 serum concentration, which should exceed 30 ng/mL (75 nmol/L); this is to start the positive effect of the optimal VD3 concentration from the beginning of a pregnancy.

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“…Although the main cause of these pains remains unknown, it is not due to a gynecological problem but caused by changes in the musculoskeletal system. In the general population, rheumatic diseases can cause back pain and hormonal changes can cause joint and back pain (2)(3)(4). In pregnancy, the center of gravity of pregnant women tends to move forward due to the growing uterus.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Low Back Pain on Quality of Life and Anxiety Levels in Pregnant Women

Eroğlu¹,

Karataş²

2021

Akdeniz Medical Journal

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Objective: Maternal low back pain is a potent risk factor for poor health quality. We aimed to investigate the prevalence and risk factors of Low back pain (LBP) and Pelvic girdle pain (PGP) during pregnancy, and their effects on quality of life. Material and Methods: Between March and August 2018, a total 160 pregnant women, who applied to outpatient clinics of the departments of Gynecology and Physical Therapy Rehabilitation Clinic, were included in this prospective study. Demographic characteristics, obstetric history of the participants, and LBP and PGP status during and before pregnancy were recorded. Severity of pain, functional capacity, Quality of life (QoL), and anxiety depression status were assessed using visual analogue scale (VAS), Oswestry Disability Questionnaire (ODQ), World Health Organization Quality of Life Scale Short Form (WHOQOL-BREF), and Hospital Anxiety and Depression Scale (HADS), respectively. Results: The prevalence of LBP and PGP were 73.4% and 28.12%, respectively. Total ODQ and VAS were significantly high in groups with LBP or PGP (p=0.000 and p=0.000, respectively). Of the WHOQOL-BREF subheadings, 'the general health' and 'physical health' parameters were significantly lower in women with LBP, whereas the 'social relationship' parameter was significantly low in those with PGP (p=0.003, p=0.002, and p=0.049, respectively). The increase in anxiety and depression scores was only associated with LBP (p=0.019 and p=0.006, respectively). Conclusion: LBP and PGP during pregnancy adversely affect QoL, leading to functional limitations, depression, and anxiety disorders.

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Evaluation of bone mineral density and its associated factors in postpartum women

Cited by 9 publications

References 28 publications

The relationship of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with bone mineral density in adolescent girls suffering from anorexia nervosa

The relationship of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with bone mineral density in adolescent girls suffering from anorexia nervosa

Vitamin D3 and its receptor in selected obstetrical complications

The Effect of Low Back Pain on Quality of Life and Anxiety Levels in Pregnant Women

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