Evaluation of body weight, serum glucose level and oxidative stress parameters of diabetic rats administered phenolic aqueous leaf extract of Vitex doniana

Abstract

Background: The present study evaluated the effect of phenolic aqueous leaf extract of Vitex doniana on body weight, serum glucose and oxidative stress parameters in diabetes mellitus (DM) rats.
 Methods: DM was induced in rats by intraperitoneal injection of 100 mg/kg alloxan monohydrate in phosphate buffered saline (PBS; pH = 7.4). A total of 36 adult male Wister albino rats were divided into 6 groups of 6 rats. The groups consist of normal untreated rats, untreated DM rats, DM rats treated with 500 mg/kg dimethylguanide (MetforminTM) and DM rats treated with 100, 200 and 400 mg/kg body weight of phenolic aqueous leaf extract of Vitex doniana. The rats were treated for 28 days. Serum glucose, malondialdehyde (MDA), glutathione (GSH) and ascorbic acid concentrations, and serum superoxide dismutase (SOD) and catalase (CAT) activities were measured using standard methods. The changes in body weight was also measured.
 Results: The results showed a significant reduction (p < 0.05) in serum glucose and MDA concentration, whereas serum SOD, CAT activities, as well as GSH and ascorbic acid concentration were significantly elevated (p < 0.05) in treated DM groups in a dose dependent manner.
 Conclusion: The results of the present study indicated that phenolic aqueous leaf extract of V. doniana promoted increased body weight, ameliorated DM and alleviated reduced antioxidant activities in alloxan-induced DM rats. Phenolic aqueous leaf extract of V. doniana could serve as a potential natural and safe remedy for the management of DM.

Administrations of Butterfly Pea Flower (Clitoria Ternatea L) Extract Reduce Oxidative Stress and Increase Body Weight of Male Wistar Rats with Diabetes

“…According to Ramadhani's 23 research, allocating pomegranate peel extract as a natural antioxidant in DM rats increased BW 23 . The same thing was also found in Obasi's study, in which the allocation of phenolic aqueous leaf extract could increase body weight in DMT2 rats 24 . The high antioxidant contents in the CT flower could reduce free radicals in the body.…”

“…Yakubu says high antioxidants can reduce ROS production and increase SOD activity 25 . The decrease in ROS can increase insulin secretion in the body so that there is an increase in glucose absorption in all tissues 24,26 .…”

Anti-obesity Activity of Extract of Curculigo orchioides Gaertn. Root in High Fat Diet-induced Obesity in Rats

“…[17] Furthermore, C. orchioides (500 mg/kg and 1000 mg/kg) decreases MDA, whereas more significantly increases SOD, CAT, and GSH levels in serum (p < 0.01). [18] Finally, after 30 days of oral administration of a C. orchioides restored body weight, exploratory behavior, and biochemical and histopathological changes caused by the constituents. Finally, after 30 days of oral administration of C. orchioides restored body weight and biochemical changes caused by the constituents.…”

Therapeutic Effects of Esomeprazole, Curcumin, Chitosan, and Curcumin-Chitosan Mixture on Ethanol-Induced Gastric Ulcer in Female Rats

“…The body weight of the rats was measured on the day of commencement of treatment and the 30 th day using an electronic weighing balance. The body weights of the rats were calculated using the following formula (Obasi et al,2019) The stomach weight of the animal was calculated after it was isolated and separated from the abdominal cavity by using electrical balance and estimated the relative weight according to the following equation (Mohammad et al, 2021):…”