Anti-obesity Activity of Extract of Curculigo orchioides Gaertn. Root in High Fat Diet-induced Obesity in Rats

Abstract

Curculigo orchioides known as Musali or Talamuli in Ayurveda. Rhizome of C. orchioides is one of a reputed drugs mentioned in the ancient books of Ayurveda and Siddha, Unani and used as an analgesic, anti-inflammatory, spermatogenic, aphrodisiac, immunostimulant, hepatoprotective, anti-asthmatic etc. To investigate the anti-obesity activity of extract of C. orchioides root in high fat diet-induced obesity rats. The five groups in this study were, group I (normal), group II received high fat diet, group III received obese rats given orlistat (50 mg/kg, p.o.), groups IV-Obese rats given extract of C. orchioides root 500 mg/kg, p.o. and groups V-Obese rats given extract of C. orchioides 1000 mg/kg, p.o. On 30th day of experiment, blood glucoses level, lipid profile and biochemical parameter were performed. Body weight of animals was significantly (p iss less than 0.05) maintained in all treatment groups. Progressive maintained blood glucose, lipid profile, and oxidative stress biomarkers were found in all treatment groups during study. The obtained results clearly suggested that C. orchioides possess pronounced anti-obesity potential

Potentiation of anti-obesity activity of berberine through its encapsulation in guar-acacia gum nanocomplexes in Wistar albino rats

“…2). Berberine decreased blood glucose level in obese rats is also supported by an earlier study [59]. The effect of gum acacia and guar gum in decreasing blood glucose levels has been described in an earlier study [60,42].…”