Evaluation of blunt pancreatic injury with contrast-enhanced ultrasonography in comparison with contrast-enhanced computed tomography

Song, Qing; Tang, Jie; Lv, Faqin; Zhang, Yan; Zhang, Jiao; Liu, Qiang; Luo, Yukun

doi:10.3892/etm.2013.1009

Cited by 6 publications

(3 citation statements)

References 20 publications

(25 reference statements)

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“…In 2013, blunt pancreatic injury was evaluated in 40 miniature pigs using conventional ultrasound, CEUS, and CECT. CEUS detection rates were significantly higher than conventional ultrasound (85% vs 52.5%, P < 0.05), and slightly higher than CECT (85% vs 82.5%, P > 0.05) [23]. Lower detection rates were seen in CECT when the depth of the lesion was less than the slice thickness; a problem that can be avoided by using CEUS.…”

Section: Kidney Traumamentioning

confidence: 79%

Emerging Applications of Contrast-enhanced Ultrasound in Trauma

Tester¹,

Ji-Bin²,

John³

et al. 2022

Advanced Ultrasound in Diagnosis and Therapy

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The use of contrast-enhanced ultrasound (CEUS) has expanded over the past decade to include a variety of diagnostic and therapeutic applications. These include urgent clinical situations that require timely diagnosis and subsequent treatment.With the introduction of microbubble ultrasound contrast agents (UCAs), CEUS provides increased sensitivity and specificity over conventional ultrasound. Within the trauma setting, CEUS benefits include point of care imaging and an ability to monitor perfusion in real-time. Additionally, UCAs are non-nephrotoxic, and can be used when contrast enhanced CT is contraindicated.In this review, we discuss recent advancements of CEUS within trauma settings.

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Section: Kidney Traumamentioning

confidence: 79%

Emerging Applications of Contrast-enhanced Ultrasound in Trauma

Tester¹,

Ji-Bin²,

John³

et al. 2022

Advanced Ultrasound in Diagnosis and Therapy

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“…Pancreatic contusion and laceration (PCL) is classified as a grade I-II injury based on the American Association for the Surgery of Trauma (AAST) organ injury scaling (2), with a conservative strategy being recommended as its primary form of management (3). Ultrasound (US)-guided percutaneous intervention (UGPI) plays an important role in the clinical management of PCL, as it is used for the delivery of local drug therapy and fluid drainage (4)(5)(6)(7)(8). In addition, particular precision in the delivery of UGPI is required in PCL because of the retroperitoneal location of the pancreas.…”

Section: Introductionmentioning

confidence: 99%

CT-US fusion imaging increases the feasibility of early ultrasound-guided percutaneous intervention of local drug therapy in pancreatic contusion and laceration

Feng¹,

Wang²,

Huang³

et al. 2021

Ann Transl Med

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Background: Multimodal fusion imaging (MMFI) was usually used to assist percutaneous procedures for difficult lesions, with most applications occurring with hepatic and prostatic interventions. This paper aimed to evaluate the precision and effectiveness of computed tomography-ultrasound (CT-US) fusion imaging (CUFI)-assisted US-guided percutaneous intervention (UGPI) in early local drug therapy for pancreatic contusion and laceration (PCL).Methods: A total of 12 pigs with PCL were randomly divided into a CUFI-assisted UGPI (MU) group (n=6) and a single UGPI (SU) group (n=6). The MU group underwent CUFI-assisted UGPI of locally applied medical protein glue (1 mL) injection while the SU group received the same therapy using two-dimensional UGPI. The duration and accuracy of each procedure were observed in the 2 groups.Results: In the MU group, the overall time of the procedure for locking the plane was 1.85±0.06 minutes.Less time was spent in the selection of the pathway and puncture site in the MU group compared with the SU group (6.56±0.42 vs. 7.61±0.44 minutes, P<0.01). The duration of puncturing and drug injection was also shorter in the MU group than in the SU group (3.41±0.30 vs. 4.20±0.20 minutes, P<0.01) and the MU group had a higher accuracy of medical protein glue injection than the SU group (100% vs. 50%, P<0.05).Conclusions: CUFI could increase the precision and effectiveness of early UGPI in the delivery of local drug therapy in PCL.

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“…In another model, following the sharp separation of the distal pancreas and hemostasis with minimal cauterization, a pig PT model was established that exhibited severe inflammation, fibrosis and necrosis ( 8 ). In a third model, the pancreas was squeezed in front of the spine using hemostatic forceps to establish a minipig model with various degrees of PT, and increased levels of amylase and lipase in the serum ( 9 ). Although these models reflect the disease symptoms of PT, they have certain limitations, such as model instability, difficult procedures, unsatisfactory levels of damage and poor clinical applicability.…”

Section: Introductionmentioning

confidence: 99%

Establishment and evaluation of a Beagle model of grade�III pancreatic trauma

Gao

Song

et al. 2018

Exp Ther Med

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Pancreatic trauma (PT) is a severe abdominal injury that is often combined with multiple organ injury. It is a severe disease that is difficult to diagnose and has a high mortality rate, particularly for grade III PT. The pathogenesis, disease progress and complications have not been fully investigated due to the lack of a reliable animal model. To address this, a Beagle model of grade III PT was established in the present study using a procedure involving rupture of the main pancreatic duct. Peripancreatic effusions and the degree of pancreatic damage were examined by routine ultrasound and contrast-enhanced ultrasound (CEUS). Also, ascites were collected for the examination of amylase and lipase levels, and whole blood samples were collected for the analysis of amylase, lipase, C-reactive protein (CRP), interleukin (IL)-6 and tumor necrosis factor (TNF)-α levels in the serum. Urine samples were also collected for the examination of trypsinogen activation peptide (TAP). In addition, the pancreas was sectioned and stained with hematoxylin and eosin. In comparison with routine ultrasound, CEUS showed a large area of focal trauma, with a depth greater than half of the anteroposterior diameter of the pancreas, with a clear boundary, clear capsular rupture and trauma induced by active bleeding. The volume of ascites peaked at 48 h post-trauma and decreased thereafter. Amylase and lipase levels in the ascites were elevated at 24 h post-trauma and significantly decreased at 48 and 72 h post-trauma (P<0.01). In addition, serum amylase and lipase levels increased to peak levels at 48 h post-trauma and then decreased (P<0.05), while serum CRP, IL-6 and TNF-α levels peaked at 24 h post-trauma and then decreased (P<0.05). Urinary TAP levels also peaked at 24 h post-trauma and subsequently decreased (P<0.05). At 72 h post-trauma, the pancreatic cells were loosely distributed, with damaged acini, hyperchromatic nuclei and severe inflammatory cell invasion. These results indicated that the Beagle model of grade III PT was satisfactorily established, and that CEUS is potentially useful as an auxiliary diagnosis method for PT. This animal model may be useful for studying the pathogenesis, disease progress and complications of PT.

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Evaluation of blunt pancreatic injury with contrast-enhanced ultrasonography in comparison with contrast-enhanced computed tomography

Cited by 6 publications

References 20 publications

Emerging Applications of Contrast-enhanced Ultrasound in Trauma

Emerging Applications of Contrast-enhanced Ultrasound in Trauma

CT-US fusion imaging increases the feasibility of early ultrasound-guided percutaneous intervention of local drug therapy in pancreatic contusion and laceration

Establishment and evaluation of a Beagle model of grade�III pancreatic trauma

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