Evaluation of blood urea, creatinine, and glucose levels as biochemical indicators of the type and severity of traumatic brain injury

Gül, Hüseyin Fatih; Dolanbay, Turgut; Şimşek, Abdullah Talha; Aras, Mustafa

doi:10.5137/1019-5149.jtn.29843-20.2

Cited by 3 publications

(5 citation statements)

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“…The distribution characteristics of roxithromycin in the body conform to the two-compartment model, with a time-dependent antibacterial effect, which suggests a promising therapeutic outcome [13,14]. Gamma globulin, the main effector molecule of the immune system, is produced by β cells of the lymphatic system [15]. Intravenous injection of gamma globulin leads to enhancement of the immune system and mitigation of toxic reactions, thereby ensuring complete elimination of viruses and bacteria [16][17][18].…”

Section: Discussionmentioning

confidence: 84%

Efficacy of roxithromycin with gamma globulin in children with mycoplasma pneumonia and its effect on immunity

Dong¹,

Qi²,

Lin³

et al. 2022

Trop. J. Pharm Res

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Purpose: To determine the efficacy of roxithromycin plus gamma globulin in the treatment of children with mycoplasma pneumonia (MPP) and its effect on immune function.Methods: From January 2019 to January 2021, 100 children with MPP assessed for eligibility in Qingdao Women and Children's Hospital, Shandong Province, China, were recruited and randomized (1:1) to receive either gamma globulin (control group) or roxithromycin plus gamma globulin (study group). Levels of tumor necrosis factor (TNF)-α, immunoglobulin (Ig)A, IgM, and IgG were evaluated. Clinical indices, including fever reduction, cough disappearance, duration of hospital stay, etc were also assessed.Results: The study group had a significantly higher clinical efficacy (88 %) than the control group (68 %) (p < 0.05). After treatment, patients in the study group showed lower levels of tumor necrosis factor (TNF)-α than those in the control group (p < 0.05). The eligible patients given roxithromycin plus gamma globulin showed significantly higher levels of immunoglobulin (Ig)A, IgM, and IgG versus those given gamma globulin alone (p < 0.05). Patients in the study group had a shorter time lapse before fever reduction, cough disappearance, lung sign disappearance, and duration of hospital stay than those in the control group (p < 0.05).Conclusion: Roxithromycin plus gamma globulin demonstrate significant benefits in the treatment of children with MPP by mitigating inflammatory response, enhancing immune function, and also significantly alleviating clinical symptoms. Thus, the combination treatment shows good potentials for use in clinical practice.

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Section: Discussionmentioning

confidence: 84%

Efficacy of roxithromycin with gamma globulin in children with mycoplasma pneumonia and its effect on immunity

Dong¹,

Qi²,

Lin³

et al. 2022

Trop. J. Pharm Res

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“…Several studies showed that a high NLR is correlated with a low GCS. For example, the patients suffering from severe traumatic brain injury usually experience alterations in cellular immune function in the first 7 days, with nearly 75% of them developing pulmonary infections [5,20]. Serum urea and creatinine, other two important biomarkers quantified in the current study are important parameters for patients' evolution.…”

Section: Resultsmentioning

confidence: 93%

“…Serum urea and creatinine, other two important biomarkers quantified in the current study are important parameters for patients' evolution. It should be noted that their values usually normalize as long as the complications (inflammatory syndrome, septic shock, pulmonary embolism) are avoided [5,20]. In addition, C-reactive protein (CRP) was another serum parameters which was quantified in the present work.…”

Section: Resultsmentioning

confidence: 98%

“…Figures 1, 2 and 3 present the most clinically relevant results obtained in terms of correlation analysis. It should be noted that no results were included for the control group, due to the low number of patients (5), which yielded unreliable results. According to the obtained results in terms of correlation analysis (Figures 1, 2 and 3), it should be noted that several statistically significant results were obtained.…”

Section: Preliminary Statistical Analysismentioning

confidence: 99%

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Efficacy Evaluation of the Association of Some Vegetal Extracts in Patients Suffering From Traumatic Brain Injury. Pilot Study (Ii)

Godeanu¹

2021

FARMACIA

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The aim of the current study was to evaluate the effects of health supplements as add-on treatment in patients suffering from cranio-cerebral trauma. During the entire monitoring period (21 days), several serum biomarkers were determined: sodium, potassium, haemoglobin, leukocytes, lymphocytes, urea, creatinine, C-reactive protein, as well as a continuous response variable: Glasgow Coma Scale. The clinical results indicated an improvement in terms of Glasgow Coma Scale compared to the control group. RezumatScopul studiului a fost de evalua efectele induse de asocierea în tratament la pacienții cu traumatism cranio-cerebral a unor suplimente alimentare. În toată perioada monitorizării (21 de zile) s-au evaluat parametrii sanguini: sodiu, potasiu, hemoglobina, leucocitele, limfocitele, ureea, creatinina, proteina C reactivă și s-a urmărit evoluția scorului Glasgow. Rezultatele clinice au arătat o îmbunătățire a stării de sănătate, comparativ cu lotul martor.

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“…There are various publications indicating that urea, creatinine, blood glucose or even infection markers may change in addition to bleeding due to head traumas (24,25). Since one of the biggest problems related to head traumas may be internal bleeding, it has been reported that there may be a greater decrease in HGB and HTC values in severe cases (moderate and severe head traumas requiring hospitalization), and it has been found that the decrease in the rate of HGB and HCT may be greater in cases with more hemorrhage in direct proportion with the increase in the severity of the trauma (1-26-27).…”

Section: Discussionmentioning

confidence: 99%

The Importance of Evaluation of Hemoglobin and Hematocrit Values in 0-2 Age Group Patients with Head Trauma

YUCEER

2024

Preprint

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Objective The aim of this study was to investigate the incidence of moderate and severe head trauma in patients aged between 0–2 years who admitted to the emergency department and were hospitalized in the service or intensive care unit, the type of trauma, the age group in which the trauma occurred, the most common localization of the trauma on the head, the severity of the trauma and the rate of decrease in hemoglobin (HGB) and hematocrit (HCT), and to understand the relationship between the rate of decrease in HGB and HCT and the severity of the trauma in this age group who cannot be fully cooperative in anamnesis and examination. Method In this study, patients, who were admitted to the emergency department of Niğde Ömer Halisdemir Training and Research Hospital between 2019 and 2022, with a Glasgow Coma Scale (GCS) of 13 and below and who were hospitalized in the service or intensive care unit, were evaluated. Among these hospitalized patients, 180 patients who underwent brain computed tomography (CT) before being hospitalized in the emergency department, whose clinical findings were determined according to PECARN rules, whose hemogram blood was taken and who were found to have no hemolysis were retrospectively analyzed. Discussion In the study, 97 male and 83 female patients were evaluated. The majority of the cases were falls with 124 (68.8%) cases. (Head traumas were evaluated according to the Pediatric Emergency Care Applied Research Network (PECARN) estimation rules and falls from a height of less than 3 feet (90cm) were considered as falls, while falls from a higher height were considered as falls from a height). It was observed that most of the trauma-related lesions occurred in the temporal region in 62 cases (34.44%). The most common lesion detected was skull bone fractures without parenchymal hemorrhage in 112 cases (62.2%). It was determined that 167 (92.8%) and 13 (7.2%) patients were hospitalized in the service and intensive care unit, respectively. Patients were classified according to their ages as between 0–1 years and between 1–2 years. There were 103 cases (57.22%) aged between 0–1 years and 77 cases (42.78%) aged between 1–2 years. Conclusion At the end of this study, it was determined that as the severity of trauma increased, the decrease in HGB and HCT values increased.

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Evaluation of blood urea, creatinine, and glucose levels as biochemical indicators of the type and severity of traumatic brain injury

Cited by 3 publications

References 0 publications

Efficacy of roxithromycin with gamma globulin in children with mycoplasma pneumonia and its effect on immunity

Efficacy of roxithromycin with gamma globulin in children with mycoplasma pneumonia and its effect on immunity

Efficacy Evaluation of the Association of Some Vegetal Extracts in Patients Suffering From Traumatic Brain Injury. Pilot Study (Ii)

The Importance of Evaluation of Hemoglobin and Hematocrit Values in 0-2 Age Group Patients with Head Trauma

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