Evaluation of biomarkers of oxidative stress and antioxidant capacity in the cord blood of preterm low birth weight neonates

Abstract

Poor fetal growth affects the development of antioxidant defenses of preterm LBW babies, predisposing them to higher oxidative stress, which in turn may partly account for increased morbidity and mortality in these infants. The presence of an association between oxidative stress biomarkers and enzymatic /non-enzymatic antioxidants in the cord blood of preterm LBW neonates suggest that increased oxidative stress may be the result of changes in the levels of certain enzymatic and non-enzymatic antioxidants due to the cause or the effect of oxidative damage occurring at the molecular level.

Facultative to strict anaerobes ratio in the preterm infant microbiota

“…Recent studies have demonstrated that premature birth is associated with an increased oxidative stress, and damage promoted by reactive oxygen species that are not properly managed by the immature antioxidant systems of preterm babies. [25][26][27][28] This increased level of oxidative stress has been related to the risk for the so called "free radical-related diseases," such as retinopathy, bronchopulmonary dysplasia and, at intestinal level, NEC 29 which are often associated with preterm birth. Interestingly, breast milk from mothers of full-term infants has been found to have a higher antioxidant capacity than that of mothers of preterm babies.…”

Idiopathic Fetal Growth Restriction: Repercussion of Modulation in Oxidative Stress

“…Decrease in TAC has also been noted in SGA babies [22]. Decrease in TAC in the cord blood of preterm low birth weight neonates have also been reported [23]. Correlation analysis revealed that blood level of MDA of both mother and cord blood correlated negatively with birth weight of the neonates.…”

Environmental Pollution and Health Consequences

“…All these data correspond to recent studies, proposing in vivo oxidative DNA damage (8-oxodG) and lipid peroxidation as biomarkers of oxidative stress in preterm LBW infants [ 32 ] and the relationship between 8-oxodG and lipid peroxidation to adverse birth outcomes due to exposure to PAHs [ 33 ].…”