Evaluation of biological fluid analysis using the sysmex XN automatic hematology analyzer

Aguadero, Vicente; Cano-Corres, Ruth; Berlanga, Eugenio; Torra, Montserrat

doi:10.1002/cyto.b.21587

Cited by 25 publications

(27 citation statements)

References 20 publications

(46 reference statements)

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“…Both the Bürker chamber and the Sysmex XN‐10 were linear. The performance of the Sysmex XN‐10 analyzer is mainly in concordance with previous findings when the body fluid channel has been used to test low concentrations of WBCs in body fluids …”

Section: Discussionsupporting

confidence: 87%

Evaluation of a routine hematology analyzer for quality control of leukoreduced plasma

Petersson

Ekblom

2019

Transfusion

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BACKGROUND: Quality control of residual white blood cells (WBCs) and red blood cells (RBCs) in leukoreduced plasma is mandatory. Although technological advances have been made, analysis of quality controls using routine hematology analyzers has not generally been introduced. The aim of this study was to evaluate if the routine hematology analyzer Sysmex XN-10, (Sysmex Nordic ApS) could be used for quality control of residual WBCs and RBCs in leukoreduced plasma. ABBREVIATIONS: CV = coefficient of variation; rRBCs = residualRBCs; rWBCs = residual WBCs.From the

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Section: Discussionsupporting

confidence: 87%

Evaluation of a routine hematology analyzer for quality control of leukoreduced plasma

Petersson

Ekblom

2019

Transfusion

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“…The comparison with XN1000 revealed high consistency and accuracy of the new instrument (Table 3 and Figure 3); however, a poor slope and a few outliers in Eos and Bas comparison were observed (Figure 3). This phenomenon may be related to the different type of analyzers equipped (XPEN60: cytochemical staining analyzer, XN1000: fluorescence staining and flow cytometry analyzer 20,22 ), or, the extremely low values of Eos and Bas tested. The similar results were also found in other previous reports 7,18,23 …”

Section: Discussionmentioning

confidence: 99%

Performance evaluation of the XPEN60 CRP&SAA, a novel automated hematology analyzer, in detecting complete blood count, C‐reactive protein, and serum amyloid A

Zong

Kan

Luo

et al. 2020

Clinical Laboratory Analysis

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Background The XPEN60 CRP&SAA (hereafter XPEN60) is a new automated hematology analyzer that can rapidly detect C‐reactive protein (CRP), serum amyloid A (SAA), and blood cell counts (CBC), including the 5‐part differential of white blood cells (5‐DIFF). The aim of this study was to evaluate the analytical performance of XPEN60. Methods The analytical performance of XPEN60 was evaluated on the basis of several parameters, including the limit of blank (LoB), limit of detection (LoD), limit of quantitation (LoQ), precision, accuracy, carryover, linearity, clinical reportable range (CRR), and interference test. In addition, method comparisons between CBC and 5‐DIFF, CRP, and SAA were performed on several systems. Results Total imprecision and accuracy for all parameters fell within acceptable criteria, and excellent measurements were observed in the dilution linearity (coefficient of determination, R2 > .99). LoBs and LoDs (0 and 0.21 mg/L for CRP, 1.1 and 2.27 mg/L for SAA) satisfy the manufacturer's statement. LoQs were 0.61 and 3.62 mg/L for CRP and SAA, respectively. No significant carryover or interference tests (<10%) were observed in this study. The comparison analysis demonstrated strong agreement between XPEN60 results and those of Sysmex–XN1000 (XN1000), except for basophils (Bas) and eosinophils (Eos). The data correlated well with E601 and Mindray CRP‐M100 for CRP. Conclusion XPEN60 was demonstrated satisfactory analytical performance, which made it well‐suited for use in clinical laboratories, emergency departments, and community hospitals.

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“…Commercial hematimetry systems are available to study of biological fluids. Aguadero et al investigated the agreement between manual technique and the Sysmex XN‐1000 analyzer for WBC, RBC, and for leukocyte differentials. Excellent agreement was observed in all types of body fluids except for ascites.…”

Section: Automation By Hematological Cytometersmentioning

confidence: 99%

Issue Highlights—September 2018 (94B5)

Wang

2018

Cytometry Part B Clinical

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Evaluation of biological fluid analysis using the sysmex XN automatic hematology analyzer

Abstract: Except for AF, the Sysmex XN-1000 results agree with those of the manual method, although to different degrees depending on the fluid type. © 2017 International Clinical Cytometry Society.

Cited by 25 publications

References 20 publications

Evaluation of a routine hematology analyzer for quality control of leukoreduced plasma

Evaluation of a routine hematology analyzer for quality control of leukoreduced plasma

Performance evaluation of the XPEN60 CRP&SAA, a novel automated hematology analyzer, in detecting complete blood count, C‐reactive protein, and serum amyloid A

Issue Highlights—September 2018 (94B5)

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