Evaluation of biochemical variables in patients with recurrent aphthous stomatitis

Koparal, Mehtap; Eğe, Bilal; Doğan, Esra; Kurt, Muhammed Yusuf; Bayazıt, Seyma

doi:10.1016/j.jormas.2022.09.015

Cited by 2 publications

(9 citation statements)

References 35 publications

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“…A total of 14 case-controlled studies comprising 1468 subjects (721 RAS patients and 747 controls) were included in this meta-analysis ( 11 – 14 , 18 , 28 – 30 , 32 – 35 , 39 , 40 ). Six studies were conducted in Turkey ( 12 – 14 , 34 , 39 , 40 ), three in Iran ( 28 , 30 , 35 ), one in Poland ( 18 ), one in India ( 33 ), one in Saudi Arabia ( 32 ), one in the United Arab Emirates ( 11 ) and one in Iraq ( 29 ). The mean age of study participants ranged from 29.26 to 40.60 years, and from 27.44 to 40.80 years in the control groups.…”

Section: Resultsmentioning

confidence: 99%

“…Of 721 RAS cases, around 56% ( n = 404) were females ( Table 1 ). Eight studies ( 28 – 30 , 32 , 34 , 35 , 39 , 40 ) included patients with minor RAS, two studies ( 18 , 33 ) included patients with minor, major, and herpetiform RAS, and one study ( 12 ) included patients with minor and major RAS, while three studies ( 11 , 13 , 14 ) did not mention the type of RAS. All the included studies assessed the serum levels of vitamin D, seven of which used ELISA (enzyme-linked immunosorbent assay) ( 29 , 30 , 32 – 35 , 40 ), while four studies ( 11 , 18 , 28 , 39 ) used ECLIA (electro-chemiluminescence binding assay).…”

Section: Resultsmentioning

confidence: 99%

“…All the included studies assessed the serum levels of vitamin D, seven of which used ELISA (enzyme-linked immunosorbent assay) ( 29 , 30 , 32 – 35 , 40 ), while four studies ( 11 , 18 , 28 , 39 ) used ECLIA (electro-chemiluminescence binding assay). Three studies ( 12 – 14 ) did not mention the type of the assay. With respect to diagnostic criteria of RAS, all studies relied on clinical presentation and history of recurrence of RAS, while one study did not provide sufficient information ( 14 ) ( Table 1 ).…”

Section: Resultsmentioning

confidence: 99%

“…In recent years, the role of vitamin D in pathogenesis of several oral diseases including RAS has generated a significant level of interest ( 12 , 14 , 17 , 18 ). Vitamin D, a lipid soluble secosteroid, plays key biological roles in calcium-phosphorus homeostasis and bone metabolism ( 17 , 19 ).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis

et al. 2023

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BackgroundGrowing evidence suggests a significant association between vitamin D deficiency and RAS. Hence, the present meta-analysis and trial sequential analysis sought to investigate the potential association between low serum vitamin D levels and RAS.MethodsPubMed, Scopus, Embase, and Web of Science were comprehensively searched on December 1st, 2022 to retrieve all relevant studies. The grey literature was also searched via ProQuest. All case-control studies on the association between vitamin D and RAS were considered. The quality appraisal of the included studies was done using Newcastle-Ottawa scale. RevMan 5.0 and trial sequential analysis (TSA) programs were used for analyses.ResultsA total of 14 case-control studies with 1468 subjects (721 RAS patients and 747 controls) were included. The pooled data revealed a significant association between low serum levels of vitamin D and the risk of RAS (mean difference = – 8.73, 95% CI: – 12.02 to – 5.44, I2 = 94%, P < 0.00001). Additionally, TSA findings indicated that the current studies surpassed the required information size, confirming that the differences were reliable.ConclusionThe available evidence suggests that Vitamin D deficiency may have a role in the pathogenesis of RAS. Therefore, evaluation of vitamin D should be considered in RAS patients. Additionally, the results support the possibility of using vitamin D supplements in the management of RAS patients with inadequate serum levels of vitamin D. Future interventional studies are required to evaluate the benefits of vitamin D replacement in prevention and treatment of RAS.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis

et al. 2023

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“…This result is also similar to that of Ozdemir et al, study who reported that thyroid nodules were present in 28.8% of patients with RAS [ 16 ]. Furthermore, it has been reported that RAS patients have some degree of iodine deficiency, so iodine mouthwash can have great therapeutic effects on RAS [ 17 , 18 ]. However, further studies required to confirm this.…”

Section: Discussionmentioning

confidence: 99%

Assessing the thyroid autoimmunity association with recurrent aphthous stomatitis

Karimi,

Lavaee,

Nematollahi

et al. 2023

BMC Oral Health

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Background Recent investigations have highlighted autoimmune origins and abnormal immune responses; particularly those related to T cell-mediated immunity and elevated T lymphocyte cells in the oral mucosa. Therefore, we investigated the relationship between recurrent aphthous stomatitis (RAS) and autoimmune thyroid diseases (ATDs) in an Iranian population. Methods A cross-sectional study was performed on 102 patients diagnosed with ATD (cases) and 102 healthy patients (controls) who had been referred for the routine dental treatment. All participants were asked for the history of RAS and their age, gender, other systemic diseases, medications, and frequency of RAS in a year. Matching was performed based on the propensity scores for age and sex. In addition, the number of lesions in each recurrence in both groups was assessed and compared. The type of thyroid disease has been assessed for case participants and has been confirmed by the endocrinologist. The chi-square test, t-test, and Mann-Whitney U test were used to analyze the data using SPSS 18. Results Patients with ATD had higher RAS than healthy controls (P = 0.040). ATD patients had 1.93 times more risk for RAS, and the frequency of RAS in a year was 3.15times higher in these patients (P = 0.011). Moreover, the frequency of RAS was higher in patients with hypothyroidism than in those with hyperthyroidism. However, there were no significant differences in the size and the number of lesions between the groups. Conclusion The risk and frequency of RAS were significantly higher in patients with ATDs. This would provide valuable insights into the underlying mechanisms and potential treatment strategies for both conditions.

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Evaluation of biochemical variables in patients with recurrent aphthous stomatitis

Cited by 2 publications

References 35 publications

Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis

Vitamin D deficiency and risk of recurrent aphthous stomatitis: updated meta-analysis with trial sequential analysis

Assessing the thyroid autoimmunity association with recurrent aphthous stomatitis

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