Evaluation of biochemical markers for detection of chronic kidney diseases (CKD) in covid positive patient among hospitalize individuals

Abstract

In evaluating diagnosis of CKD can detect in covid-19 positive patient by estimation of few bio-chemical markers like erythropoietin level, cystatin-C (CysC), BTP (beta trace protein.), IL- 6, IL-8 and TNF alpha. Those chemical parameters usually may be potential diagnostic aspect. The study was undertaken to determine the prevalence of biochemical markers of CKD in covid positive patients those are taking dialysis twice in a week and also to evaluate the risk factors among 50 ICU and non-ICU individuals at salboni super speciality hospital, WB over a period of 6 months (June 2020 to Nov 2020). Blood samples were collected by using venipuncture technique from ICU and non-ICU individuals then serum is separated from the whole blood sample. Then the serum samples were performing CLIA immunoassay technique for detecting those biomarkers. Erythropoietin level was decreased significantly across CKD in age group (40-49) and also age group (50-59) for female and for the male age group (30-39) is significantly decreased in EPO level. Whereas the rest age groups are significantly increased in EPO level. Beta trace protein of all the groups are significantly increased remaining age group (40-49) for male. Cystatin C level, IL-6, IL-8, TNF alpha level is significantly increased of all the groups both male and female. This is in contrast to the bio-chemical markers of CKD in covid patient, many of which are new and unfamiliar to clinicians, relatively costly, and lack the demonstrated clinical benefit over current methods to fully justify their wide implementation.