Evaluation of berberine efficacy in reducing the effects of aflatoxin B1 and ochratoxin A added to male broiler rations

Malekinezhad, Pouyan; Ellestad, Laura E.; Afzali, Nazar; Farhangfar, Seyyed Homayoun; Omidi, Arash; Mohammadi, Abbas

doi:10.1016/j.psj.2020.10.040

Cited by 30 publications

(36 citation statements)

References 63 publications

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“…Similar studies have confirmed this result by Tong et al. (2020) ( Figure 2 B) and Malekinezhad et al. (2020) ( Figure 2 C).…”

Section: Gitsupporting

confidence: 86%

“…The arrows “→” indicate a intestinal pathological damage or breakage of broiler chickens received 50 µg of OTA/kg body weight/day for 21 d ( Tong et al., 2020 ). (C) Histological structures of the ileum at 42 d of age (magnification, 5×): negative control diet with normal epithelial cells in the apical region of villi; (D) diet contaminated with OTA; the villus height was decreased and the apical region of epithelial cells was shedding ( Malekinezhad et al., 2020 ). Abbreviation: OTA, ochratoxin A.…”

Section: Gitmentioning

confidence: 99%

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Ochratoxin A: its impact on poultry gut health and microbiota, an overview

et al. 2021

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Ochratoxin A ( OTA ) is a widespread mycotoxin, that has strong thermal stability, and is difficult to remove from feed. OTA is nephrotoxic, hepatotoxic, teratogenic, immunotoxic, and enterotoxic to several species of animals. The gut is the first defense barrier against various types of mycotoxins present in feed that enter the body, and it is closely connected to other tissues through enterohepatic circulation. Compared with mammals, poultry is more sensitive to OTA and has a lower absorption rate. Therefore, the gut is an important target tissue for OTA in poultry. This review comprehensively discusses the role of OTA in gut health and the gut microbiota of poultry, focusing on the effect of OTA on digestive and absorptive processes, intestinal barrier integrity, intestinal histomorphology, gut immunity, and gut microbiota. According to the studies described to date, OTA can affect gut dysbiosis, including increasing gut permeability, immunity, and bacterial translocation, and can eventually lead to gut and other organ injury. Although there are many studies investigating the effects of OTA on the gut health of poultry, further studies are needed to better characterize the underlying mechanisms of action and develop preventative or therapeutic interventions for mycotoxicosis in poultry.

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“…Similar studies have confirmed this result by Tong et al. (2020) ( Figure 2 B) and Malekinezhad et al. (2020) ( Figure 2 C).…”

Section: Gitsupporting

confidence: 86%

Section: Gitmentioning

confidence: 99%

Ochratoxin A: its impact on poultry gut health and microbiota, an overview

et al. 2021

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“…The mechanism behind the adverse effects of ingested mycotoxins in BW of birds has not been fully elucidated; however, the aforementioned mycotoxins have been associated with anorexia, listlessness, and metabolic changes, as a result of the liver damage and the decrease of the activity of digestive enzymes in combination with the decrease of nutrient digestibility due to the changes on the intestinal environment [ 33 , 34 ]. In addition, AFB 1 inhibits the digestibility of fats by reducing both enzyme activity and bile acid production necessary for their digestion and absorption [ 35 ].…”

Section: Discussionmentioning

confidence: 99%

Investigation of a Novel Multicomponent Mycotoxin Detoxifying Agent in Amelioration of Mycotoxicosis Induced by Aflatoxin-B1 and Ochratoxin A in Broiler Chicks

Tsiouris

Tassis

Raj³

et al. 2021

Toxins

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The present study was designed to determine the efficacy of a novel multicomponent mycotoxin detoxifying agent (MMDA) containing modified zeolite (Clinoptilolite), Bacillus subtilis, B. licheniformis, Saccharomyces cerevisiae cell walls and silymarin against the deleterious effects of Aflatoxin B1 (AFB1) and Ochratoxin A (OTA) in broiler chicks. A total of 160 one-day-old Ross 308® broiler chicks were randomly allocated in four treatment groups, with four replicates, according to the following experimental design for 42 days. Group A received a basal diet; Group B received a basal diet contaminated with AFB1 and OTA at 0.1 mg/kg and 1 mg/kg, respectively; Group C received a basal diet contaminated with AFB1 and OTA and MMDA at 1 g/kg feed, and Group D received a basal diet contaminated with AFB1 and OTA and MMDA at 3 g/kg feed. Results showed that ingested mycotoxins led to significant (p ≤ 0.05) reduction in body weight and feed conversion from 25 days of age, induced histopathological changes, increased the pH of the intestinal content, and altered the biochemical profile of birds with significantly (p ≤ 0.05) increased aspartate aminotransferase (AST) values (p ≤ 0.05). On the other hand, the supplementation of MMDA significantly (p ≤ 0.05) improved the feed conversion ratio (FCR) during the second part of the study, diminished biochemical alterations, reduced pH in jejunal and ileal content, and E. coli counts in the caeca of birds (p ≤ 0.05). It may be concluded that the dietary supplementation of the MMDA partially ameliorated the adverse effects of AFB1 and OTA in broilers and could be an efficient tool in a mycotoxin control program.

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“…Moghaddam et al (19) reported that administration of 50 and 100 mg/kg BBR (doses corresponding to our study), significantly reduced MDA in rats. Similarly, a recent investigation showed that BBR addition to aflatoxin B1 and ochratoxin A contaminated broilers diet, partially restored levels of MDA and GSH-Px activity (18).…”

Section: Biomarkers Of Oxidative Stress and Antioxidant Statusmentioning

confidence: 72%

“…Numerous reports in both cell culture (16) and animal models (17) have also highlighted the inhibitory effect of BBR on oxidative stress. The antioxidant activity of BBR is well documented as it altered the levels of antioxidant enzymes and oxidative stress markers such as glutathione (GSH), a lipid oxidation product that is reduced in oxidative stress, and malondialdehyde (MDA) that is increased in oxidative stress (18)(19)(20).…”

Section: Introductionmentioning

confidence: 99%

Pre- and Post-partum Berberine Supplementation in Dairy Goats as a Novel Strategy to Mitigate Oxidative Stress and Inflammation

et al. 2021

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As in dairy cattle, goats during the transition period face risk factors, in particular negative energy balance (NEB), inflammation, and impairment of the antioxidant response. The current study determined the effects of pre- and post-partum berberine (BBR) supplementation on antioxidant status and inflammation response during the transition period in dairy goats. Twenty-four primiparous Saanen goats were randomly divided into four groups: control (CON, without BBR) and supplemented with 1 g/day BBR (BBR1), 2 g/day BBR (BBR2), or 4 g/day BBR (BBR4). The blood samples were collected weekly from 21 days pre-partum to 21 days post-partum. Compared with CON, supplementation with either BBR2 or BBR4 decreased (P ≤ 0.05) the levels of plasma non-esterified fatty acids (NEFA) at kidding and thereafter an increased (P ≤ 0.05) the plasma levels of glucose and insulin. Following BBR ingestion, blood antioxidant status elevated throughout the transition period, so that total antioxidant capacity (TAC), glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), and catalase activity were increased (P ≤ 0.05) and plasma malondialdehyde (MDA) was decreased (P ≤ 0.05). Likewise, paraoxonase (PON) was reduced (P ≤ 0.05) in goats fed BBR2 and BBR4. The levels of haptoglobin, ceruloplasmin, and bilirubin were reduced (P ≤ 0.05) by BBR2 and BBR4 immediately before kidding and thereafter. The results demonstrated that supplementation of either 2 or 4 g/day BBR enhanced antioxidant capacity and immune function of transition goats and improved post-partum performance showing its beneficial effect to mitigate oxidative stress and inflammation during the transition period in dairy goats.

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Evaluation of berberine efficacy in reducing the effects of aflatoxin B1 and ochratoxin A added to male broiler rations

Cited by 30 publications

References 63 publications

Ochratoxin A: its impact on poultry gut health and microbiota, an overview

Ochratoxin A: its impact on poultry gut health and microbiota, an overview

Investigation of a Novel Multicomponent Mycotoxin Detoxifying Agent in Amelioration of Mycotoxicosis Induced by Aflatoxin-B1 and Ochratoxin A in Broiler Chicks

Pre- and Post-partum Berberine Supplementation in Dairy Goats as a Novel Strategy to Mitigate Oxidative Stress and Inflammation

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