Evaluation of Autonomic Nervous System, Saliva Cortisol Levels, and Cognitive Function in Major Depressive Disorder Patients

Ngampramuan, Sukonthar; Tungtong, Puttichai; Mukda, Sujira; Jariyavilas, Apichat; Sakulisariyaporn, Chanin

doi:10.1155/2018/7343592

Cited by 17 publications

(17 citation statements)

References 16 publications

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“…Likewise, FM and MDD share several common symptoms linked to the hypothalamic-pituitary-adrenal (HPA) axis and autonomic dysregulation systems for stress regulation, and their physiological markers are commonly found in FM and MDD 10,11. Cortisol and melatonin are two hormones that regulate the 24-hour pattern of bodily functions 12.…”

Section: Introductionmentioning

confidence: 99%

Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity

Caumo¹,

Hidalgo²,

Souza³

et al. 2019

JPR

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ObjectiveThis study compared urinary 6-sulfatoxymelatonin (aMT6s) over 24 hours among fibromyalgia (FM), major depression disorder (MDD), and healthy control (HC) groups, and examined whether rhythm is correlated with depressive symptoms. To answer this question we compared the rhythm of urinary aMT6s secretion among each group in four time series: morning (06:00–12:00 hours), afternoon (12:00–18:00 hours), evening (18:00–24:00 hours), and night (24:00–06:00 hours). In the FM subjects, we assessed if the rhythm of urinary aMT6s secretion is associated with pain severity, sleep quality, number of trigger points (NTPs), and the pain pressure threshold (PPT).Patients and methodsWe included 54 women, aged 18–60 years with diagnosis of FM (n=18), MDD (n=19), and HC (n =17). The 24-hour urinary aMT6s was evaluated according to four standardized periods. The assessment instruments were the Hamilton Depression Rating Scale (HDRS), Pittsburgh Sleep Quality Index, and Fibromyalgia Impact Questionnaire.ResultsA generalized estimating equation revealed no difference in the daily load of aMT6s secretion among the three groups (P=0.49). However, at the daily time (06:00–18:00 hours), the load secretion of aMT6s reached 41.54% and 60.71% in the FM and MDD, respectively, as compared to 20.73% in the HC (P<0.05). A higher score in the HDRS was positively correlated with the amount of aMT6s secretion during daytime (06:00–18:00 hours). Also, multivariate linear regression revealed that in FM subjects, the aMT6s secretion during daytime (06:00–18:00 hours) was negatively correlated with the PPTlog (partial η2=0.531, P=0.001). However, it was positively correlated with depressive symptoms (partial η2=0.317, P=0.01); PQSI (partial η2=0.306, P=0.017), and NTPs (partial η2=0.23, P=0.04).ConclusionA more significant load of aMT6s secretion during daytime hours was observed in MDD and FM subjects compared to HC. These findings help to comprehend the biological basis of these disorders and show how disruption in melatonin secretion is positively correlated with clinical symptoms.

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Section: Introductionmentioning

confidence: 99%

Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity

Caumo¹,

Hidalgo²,

Souza³

et al. 2019

JPR

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“…Unhealthy lifestyle may cause adverse vascular events after PCI [29]. Second, several studies have shown that depression may cause a dysregulation of the autonomic nervous system including low heart rate variability, high mean heart rate [30, 31]. Besides, the sympathetic nervous system can be continuously active without the antagonism of the parasympathetic nervous system in the context of depression, which may lead to the increase of pro-inflammatory cytokines and the decrease of anti-inflammatory cytokines, resulting in the state of inflammation [32, 33].…”

Section: Discussionmentioning

confidence: 99%

Association between Depression and Clinical Outcomes following Percutaneous Coronary Intervention: A Meta-Analysis

et al. 2022

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Background: Several studies suggested that depression was associated with poor prognosis following percutaneous coronary intervention (PCI) in coronary heart disease (CHD), whereas other studies showed that there were no associations between depression and poor outcomes. Objectives: Considering these problems, this meta-analysis was conducted to evaluate the relationship between depression and clinical outcomes after PCI. Methods: Articles published before July 2021 were analyzed from the databases: PubMed, Web of Science, EMBASE, Medline, and Google Scholar. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed to generate a pooled effect size and 95% CI with a random or fixed effects model. Q test and I2 were used to assess heterogeneities between studies. Results: The meta-analysis indicated that depression was associated with a higher risk of major adverse cardiac events (MACE) after PCI with a random effects model (HR = 1.89, 95% CI: 1.33–2.68, I2 = 57.0%, p = 0.023). The study indicated that depression was associated with a higher risk of all-cause mortality after PCI with a fixed effects model (HR = 1.71, 95% CI: 1.43–2.05, I2 = 0.0%, p = 0.756). The study indicated no significant association between depression and risk of repeat revascularization after PCI with a random effects model (HR = 2.10, 95% CI: 0.96–4.58, I2 = 68.9%, p = 0.022). Conclusion: Results indicated that depression is associated with adverse clinical outcomes in CHD patients’ post-PCI. Appropriate mental health check and psychological treatment may be necessary for the prognosis of CHD patients who receive PCI.

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“…Both ANS divisions are highly coordinated in a dynamic sympathovagal balance aimed at maintaining physiological homeostasis. Disruption in ANS homeostasis, characterized by sympathetic overactivity and/or vagal underactivity, is an important contributor to adverse cardiac outcomes associated with depression [70,71]. Heart rate variability (HRV), that is, spontaneous oscillations of heart rate around its mean value, is determined by the dynamic interaction of the acceleratory sympathetic nervous system and deceleratory parasympathetic nervous system, indicating a healthy and adaptive organism.…”

Section: Role Of Autonomic Nervous System In Depressive Disordermentioning

confidence: 99%

Novel Insight into Neuroimmune Regulatory Mechanisms and Biomarkers Linking Major Depression and Vascular Diseases: The Dilemma Continues

Tonhajzerová

Sekaninova

Olexova

et al. 2020

IJMS

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Major depressive disorder (MDD) represents a serious health problem estimated to affect 350 million people globally. Importantly, MDD has repeatedly emerged as an etiological or prognostic factor in cardiovascular disease (CVD) development, including vascular pathology. Several linking pathomechanisms between MDD and CVD involve abnormal autonomic regulation, inflammation, and endothelial dysfunction as an early preclinical stage of atherosclerosis. However, the cause of accelerated atherosclerosis in MDD patients remains unclear. Recently, the causal relationships between MDD and mediator (e.g., inflammation and/or endothelial dysfunction), as well as the causal pathways from the mediator to atherosclerosis, were discussed. Specifically, MDD is accompanied by immune dysregulation, resulting in increased production of proinflammatory cytokines (e.g., interleukin (IL)-6 and tumor necrosis factor (TNF)-α), which could lead to depression-linked abnormalities in brain function. Further, MDD has an adverse effect on endothelial function; for example, circulating markers of endothelial dysfunction (e.g., soluble adhesion molecules, von Willebrand factor) have been linked with depression. Additionally, MDD-linked autonomic dysregulation, which is characterized by disrupted sympathovagal balance associated with excessive circulating catecholamines, can contribute to CVD. Taken together, activated inflammatory response, endothelial dysfunction, and autonomic dysregulation could affect gradual atherosclerosis progression, resulting in a higher risk of developing CVD in MDD. This review focused on the pathomechanisms linking MDD and CVD with respect to neuroimmune regulation, and the description of promising biomarkers, which is important for the early diagnosis and personalized prevention of CVD in major depression.

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Evaluation of Autonomic Nervous System, Saliva Cortisol Levels, and Cognitive Function in Major Depressive Disorder Patients

Cited by 17 publications

References 16 publications

<p>Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity</p>

<p>Melatonin is a biomarker of circadian dysregulation and is correlated with major depression and fibromyalgia symptom severity</p>

Association between Depression and Clinical Outcomes following Percutaneous Coronary Intervention: A Meta-Analysis

Novel Insight into Neuroimmune Regulatory Mechanisms and Biomarkers Linking Major Depression and Vascular Diseases: The Dilemma Continues

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