Novel Insight into Neuroimmune Regulatory Mechanisms and Biomarkers Linking Major Depression and Vascular Diseases: The Dilemma Continues

Tonhajzerová, Ingrid; Sekaninova, Nikola; Olexova, Lucia Bona; Višňovcová, Zuzana

doi:10.3390/ijms21072317

Cited by 29 publications

(24 citation statements)

References 83 publications

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“…Anxiety symptoms are an adaptive emotional response to physical or mental challenges and have been shown to have protective functions and damaging effects, producing anxiety disorder ( 22 ). Depressive symptoms are about bad mood and negative beliefs and may lead to some consequences, such as pessimism, personal quarrel, and even suicide behavior ( 23 , 24 ). Studies have reported increasing rates of mental disorders in the university setting.…”

Section: Introductionmentioning

confidence: 99%

Social Support and Suicide Risk Among Chinese University Students: A Mental Health Perspective

Chu

Yang

Zhou

et al. 2021

Front. Public Health

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Background: World Health Organization recognizes suicide as a public health priority. This study aimed to investigate the risk life events which led university students to consider suicide and explore the protective mechanism of social support (including subjective support, objective support, and support utilization) on suicide risk.Methods: Three thousand nine hundred and seventy-two university students were recruited in Harbin, China. Social Support Rating Scale, Self-Rating Anxiety Scale, the Beck Depression Inventory, and the 25-item scale of suicide acceptability were used to collect participants' information. Descriptive statistics, Pearson's correlation, and mediation analysis were employed for statistical analysis.Results: “Drug addict,” “infected with HIV,” and “incurable illness” were the top three events that led university students to consider suicide. Social support played an important protective role against suicide risk. Subjective support and support utilization had total effects on suicide acceptability, including direct and indirect effects. Anxiety (indirect effect = −0.022, 95% CI = −0.037 ~ −0.009) and depressive symptoms (indirect effect = −0.197, 95% CI = −0.228 ~ −0.163) mediated the relationship between subjective support and suicide acceptability; meanwhile, the association between support utilization and suicide acceptability was mediated by anxiety (indirect effect = −0.054, 95% CI = −0.088 ~ −0.024) and depressive symptoms (indirect effect = −0.486, 95% CI = −0.558 ~ −0.422). However, the protective impact of objective support worked totally through decreasing anxiety (indirect effect = −0.018, 95% CI = −0.035 ~ −0.006) and depressive symptoms (indirect effect = −0.196, 95% CI = −0.246 ~ −0.143). Moreover, the mediation effects of depressive symptoms had stronger power than anxiety in the impact of social support on suicide risk.Conclusions: Among Chinese university students, suicide acceptability was elevated when there was a health scare. Social support effectively reduced suicide risk via decreasing anxiety and depressive symptoms. From the mental health perspective, families, peers, teachers, and communities should work together to establish a better social support system for university students, if necessary, help them to seek professional psychological services.

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Section: Introductionmentioning

confidence: 99%

Social Support and Suicide Risk Among Chinese University Students: A Mental Health Perspective

Chu

Yang

Zhou

et al. 2021

Front. Public Health

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“…This proposition is supported by a study reporting a positive and robust correlation between the extent of vascular inflammation and arterial stiffness and the severity of depressive symptoms and dysfunction [ 401 ], reviewed in [ 402 ]. Understandably, there has been a great deal of research into the causes of endothelial dysfunction in MDD and most evidence suggests that it may be due at least in part to increased NADPH oxidase-mediated superoxide levels in ECs and a subsequent reduction in NO-mediated vasodilation [ 403 , 404 ], reviewed in [ 405 ].…”

Section: Potential Generators Of Ec Dysfunction and Activation In Mddmentioning

confidence: 99%

Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments

Morris

Puri²,

Olive

et al. 2020

BMC Med

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Background Potential routes whereby systemic inflammation, oxidative stress and mitochondrial dysfunction may drive the development of endothelial dysfunction and atherosclerosis, even in an environment of low cholesterol, are examined. Main text Key molecular players involved in the regulation of endothelial cell function are described, including PECAM-1, VE-cadherin, VEGFRs, SFK, Rho GEF TRIO, RAC-1, ITAM, SHP-2, MAPK/ERK, STAT-3, NF-κB, PI3K/AKT, eNOS, nitric oxide, miRNAs, KLF-4 and KLF-2. The key roles of platelet activation, xanthene oxidase and myeloperoxidase in the genesis of endothelial cell dysfunction and activation are detailed. The following roles of circulating reactive oxygen species (ROS), reactive nitrogen species and pro-inflammatory cytokines in the development of endothelial cell dysfunction are then described: paracrine signalling by circulating hydrogen peroxide, inhibition of eNOS and increased levels of mitochondrial ROS, including compromised mitochondrial dynamics, loss of calcium ion homeostasis and inactivation of SIRT-1-mediated signalling pathways. Next, loss of cellular redox homeostasis is considered, including further aspects of the roles of hydrogen peroxide signalling, the pathological consequences of elevated NF-κB, compromised S-nitrosylation and the development of hypernitrosylation and increased transcription of atherogenic miRNAs. These molecular aspects are then applied to neuroprogressive disorders by considering the following potential generators of endothelial dysfunction and activation in major depressive disorder, bipolar disorder and schizophrenia: NF-κB; platelet activation; atherogenic miRs; myeloperoxidase; xanthene oxidase and uric acid; and inflammation, oxidative stress, nitrosative stress and mitochondrial dysfunction. Conclusions Finally, on the basis of the above molecular mechanisms, details are given of potential treatment options for mitigating endothelial cell dysfunction and activation in neuroprogressive disorders.

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“…The shift from the monoaminergic theory of depression to recognizing the importance of cytokine signaling, neuroinflammatory, and neuroendocrine pathways with external stressors creates a complex and multifaceted model of depression [ 62 , 72 , 73 ]. Imaging studies have tied peripheral inflammation to altered brain structure integrity in depression [ 74 ].…”

Section: Emerging Concepts: Inflammation and Disease Activitymentioning

confidence: 99%

Patient-Centered Care in Psoriatic Arthritis—A Perspective on Inflammation, Disease Activity, and Psychosocial Factors

Batko

2020

JCM

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Psoriatic arthritis (PsA) is a seronegative spondyloarthropathy characterized by skin lesions, dactylitis, and enthesitis. Patients with PsA suffer from a variety of psychosocial difficulties and nonspecific symptoms early on in the disease course and continue to experience progressive disease due to delays in diagnosis and treatment. Symptoms initially viewed as somatization could lead to undertreatment and promote psychological distress, poor coping, and negative patient–provider relationships. Pain and fatigue are important complaints that affect the patient’s perception and may need to be addressed with a multidisciplinary approach. Maladaptive cognitive responses can lead to a negative illness perception and impact patient beliefs and concerns over treatment, as well as nonadherence. An underlying inflammatory component in affective disorders has been examined, though whether and how it may interact mechanistically in PsA warrants interest. Cognitive behavioral therapy represents a nonpharmacological treatment modality that can be combined with cytokine-targeted therapy to address both somatic and psychological complaints. Future directions for research include: (1) Elucidating nonspecific manifestations (e.g., subclinical stage, differential with functional syndromes) of PsA and how they impact diagnosis and management; (2) characterizing immune-mediated components of mood disorders in PsA; and (3) whether a bidirectional approach with abrogating inflammation and psychotherapeutic support leads to improved outcomes.

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Novel Insight into Neuroimmune Regulatory Mechanisms and Biomarkers Linking Major Depression and Vascular Diseases: The Dilemma Continues

Cited by 29 publications

References 83 publications

Social Support and Suicide Risk Among Chinese University Students: A Mental Health Perspective

Social Support and Suicide Risk Among Chinese University Students: A Mental Health Perspective

Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments

Patient-Centered Care in Psoriatic Arthritis—A Perspective on Inflammation, Disease Activity, and Psychosocial Factors

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