Evaluation of autologous and homologous platelet rich plasma as a surgical wound healing promoter in rabbits

Abstract

The present study compared the efficacy of autologous and homologous platelet rich plasma (PRP) as a surgical wound healing promoter in rabbits. Sixteen adult healthy rabbits were divided into two groups i.e. A and B. Group A was treated with autologous platelet rich plasma (APRP) and group B was treated with homologous platelet rich plasma (HPRP). Both groups were operated for skin grafting (auto grafting) at two (PRP treated experimental and control) sites. Clinical evaluation of PRP was performed by using macroscopic (edema, exudation, coloration, temperature, cosmetic appearance and healing status) and microscopic (acute inflammation, fibroblast proliferation and granulation tissue proliferation) parameters. The healing status, coloration and cosmetic appearance of APRP treated group were more satisfactory than HPRP treated group. APRP group also showed less inflammation, edema and more granular tissue proliferation as compare to HPRP group. It was concluded that autologous PRP is an efficient surgical wound healing promoter in rabbits.

​​The Effect of Platelet Rich Plasma on Wound Healing in the Repair of Experimental Penile Fractures

“…It is known that local applications of growth factors to chronic injuries generate a synergic effect in wound healing and have a significant therapeutic potential. Similarly, it has been reported in several clinical studies that growth factors play a key role in the repair of hard and soft tissue, thus topical treatments facilitate wound healing in normal tissue and heal persistent non-healing wounds (Debus et al 2000;Tahir et al, 2018). They are also efficiently used in skin lesions, urology, orthopedics and plastic surgery, ophthalmology, dental surgery and the repair of various tissues (Parafioriti et al, 2011;Chung et al, 2015;Roshini et al, 2019;Sardari et al, 2011;Carter et al, 2011).…”