Evaluation of autofluorescence and photodynamic diagnosis in assessment of bladder lesions

Bochynek, Kamil; Aebisher, David; Gasiorek, Monika; Cieślar, Grzegorz; Kawczyk‐Krupka, Aleksandra

doi:10.1016/j.pdpdt.2020.101719

Cited by 2 publications

(3 citation statements)

References 62 publications

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“…The images are analyzed and are presented as a single real-time image on a monitor. Researchers have proposed algorithms that increase the effectiveness of detecting abnormal tissue, especially dysplastic and neoplastic, but also inflammed tissue in pulmonology, gastrology, and urology [ 24 , 25 ]. High-fluorescence fields are interlaced with low-fluorescence areas that are close to normal, or clearly lower, and correlated with the NCV index [ 26 , 27 , 28 , 29 ].…”

Section: Methodsmentioning

confidence: 99%

Photodynamic Therapy for the Treatment of Infected Leg Ulcers—A Pilot Study

et al. 2021

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Chronic and infected leg ulcers (LUs) are painful, debilitating, resistant to antibiotics, and immensely reduce a patient’s quality of life. The purpose of our study was to demonstrate the efficacy of photodynamic therapy (PDT) for the treatment of infected chronic LUs. Patients were randomized into two experimental groups: the first group received 5-aminolevulinic acid photodynamic therapy (ALA-PDT) (10 patients), and the second group of 10 patients received local octenidine dihydrochloride (Octenilin gel) exposed to a placebo light source with an inserted filter that mimiced red light. In the PDT group, we used 20% ALA topically applied for 4 hrs and irradiation from a Diomed laser source with a wavelength of 630 nm at a fluency of 80 J/cm2. ALA-PDT was performed 10 times during a 14-day hospitalization in 10 patients of both sexes aged 40–85 years with chronic leg ulcers. Treatments were carried out at 3-week intervals for 3–5 cycles. At 8-month follow-up with the PDT group, complete remission (CR) was obtained in four patients (40%), partial response (>50% reduction in ulcer diameter) in four patients (40%), and no response in two patients (20%) who additionally developed deterioration of the local condition with swelling, erythema, and inflammation. To assess the degree of pain during the trials, we used a numeric rating scale (NRS). From the preliminary results obtained, we concluded that PDT can be used to treat leg ulcers as a minimally invasive and effective method with no serious side effects, although further studies on a larger group of patients with LUs are warranted.

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Section: Methodsmentioning

confidence: 99%

Photodynamic Therapy for the Treatment of Infected Leg Ulcers—A Pilot Study

et al. 2021

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“…Similar to PDD, LIF is involved in light emission and excitation, as well as the absorption of endogenous porphyrin compounds. The difference in spectra is mainly the result of cellular oxygenation processes and reduction between tumor cells and normal tissues, as evidenced by changes in the NAD to NADH ratio [18]. For the past years, AFC was commonly applied as a complementary tool to standard cystoscopy.…”

Section: Fluorescence Cystoscopymentioning

confidence: 99%

“…Optical filters and algorithms convert images into spatial maps of the intensity of autofluorescence, which can significantly improve sampling accuracy of tissue biopsies and pathology examinations. The Onco-LIFE system (photo-induced fluorescence endoscopy) provides an objective comparison of green and red self-fluorescence by calculating a ratio (NCV: numerical color value), which enables precise localization of small pathological changes [18,19]. Compared to WLC, AFC and PDD exhibit higher sensitivity and better ability to perform biopsies.…”

Section: Fluorescence Cystoscopymentioning

confidence: 99%

Advances in Diagnosis and Therapy for Bladder Cancer

2022

Cancers

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Bladder cancer (BCa) is one of the most common and expensive urinary system malignancies for its high recurrence and progression rate. In recent years, immense amounts of studies have been carried out to bring a more comprehensive cognition and numerous promising clinic approaches for BCa therapy. The development of innovative enhanced cystoscopy techniques (optical techniques, imaging systems) and tumor biomarkers-based non-invasive urine screening (DNA methylation-based urine test) would dramatically improve the accuracy of tumor detection, reducing the risk of recurrence and progression of BCa. Moreover, intravesical instillation and systemic therapeutic strategies (cocktail therapy, immunotherapy, vaccine therapy, targeted therapy) also provide plentiful measures to break the predicament of BCa. Several exploratory clinical studies, including novel surgical approaches, pharmaceutical compositions, and bladder preservation techniques, emerged continually, which are supposed to be promising candidates for BCa clinical treatment. Here, recent advances and prospects of diagnosis, intravesical or systemic treatment, and novel drug delivery systems for BCa therapy are reviewed in this paper.

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Evaluation of autofluorescence and photodynamic diagnosis in assessment of bladder lesions

Cited by 2 publications

References 62 publications

Photodynamic Therapy for the Treatment of Infected Leg Ulcers—A Pilot Study

Photodynamic Therapy for the Treatment of Infected Leg Ulcers—A Pilot Study

Advances in Diagnosis and Therapy for Bladder Cancer

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