Evaluation of apparent diffusion coefficient and MR volumetry as independent associative factors for extra‐prostatic extension (EPE) in prostatic carcinoma

Abstract

MR volumetry and percentage of positive core biopsies are associated with EPE; whereas, in this study, other clinical and MR parameters including mean ADC and subjective T2W-MR analysis were not useful for assessment of EPE.

Evaluation of MRI for diagnosis of extraprostatic extension in prostate cancer

“…Tumor size and length of capsular contact were both larger in tumors with EPE in our study. Tumor size and tumor volume, when measured on MRI, have both been previously shown to be associated with EPE . In our study, larger tumors measured on axial T 2 W MRI were associated with EPE.…”

“…Tumor size and tumor volume, when measured on MRI, have both been previously shown to be associated with EPE. 21,36 In our study, larger tumors measured on axial T 2 W MRI were associated with EPE. This is concordant with the study by Lim et al, 36 who showed that a simple measurement of maximal transverse tumor size is accurate for diagnosis of EPE.…”

“…The results from subjective assessment of EPE in our study compares favorably with what has been published previously, namely, that subjective assessment can be a specific imaging finding for EPE but lacks sensitivity . The low interobserver agreement in our study for assessment of EPE is also concordant with prior work …”

“…12,13 The low interobserver agreement in our study for assessment of EPE is also concordant with prior work. 12,18,21 Two previous studies have demonstrated that an increasing PI-RADS v1 sum score was reasonably predictive of EPE. 28,39 More recently, Lim et al 36 showed that PI-RADS v2 category 5 lesions were associated with higher Gleason scores and the presence of EPE compared to category 4 lesions.…”

MRI assessment of pathological stage and surgical margins in anterior prostate cancer (APC) using subjective and quantitative analysis

“…Quantitative analysis of tumor size and, more important, the leading edge of tumor with respect to the AFMS when measured using fused images composed of high b value DWI and high resolution T 2 W‐MRI performed best for diagnosis of EPE and PSM. Lim et al previously demonstrated that tumor size and volume correlated with pathological stage, and our results are concordant. To our knowledge, we are the first to describe the use of fused DWI/ T 2 W MR images for measurement of the leading edge of tumor in APC.…”