Evaluation of anxiolytic, sedative, and antioxidant activities of Vitex peduncularis Wall. leaves and investigation of possible lead compounds through molecular docking study

Auniq, Reedwan Bin Zafar; Chy, Md. Nazim Uddin; Adnan, Md.; Chowdhury, Md. Riad; Dutta, Trishala; Ibban, Sadab Sipar; Jahan, Israt; Tona, Marzia Rahman; Shima, Mutakabrun; Sawon, Md. Imtiajul Habib; Chakrabarty, Nishan; Hossain, Shakawat; Paul, Arkajyoti

doi:10.1007/s13596-020-00461-7

Cited by 3 publications

(5 citation statements)

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“…The separated animals were treated as described in Section 2.4 (experimental design section). Thirty min after the treatment, each treated mouse was placed in the middle square of the apparatus and we recorded the head dipping and time for alatency of 1st head dipping during a 5 min period [ 22 ].…”

Section: Methodsmentioning

confidence: 99%

Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways

Moni

Adnan

Tareq

et al. 2021

Life

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Syzygium fruticosum (SF), a valuable Bangladeshi fruit, is considered an alternative therapeutic agent. Mainly, seeds are used as nutritional phytotherapy to ease physical and mental status by preventing chronic diseases. Here, we scrutinized theS. fruticosum seed’s fundamental importance in traditional medicine by following an integrated approach combining in vivo, in vitro,and in silico studies. The SF was fractionated with different solvents, and the ethyl acetate fraction of SF (EaF-SF) was further studied. Mice treated with EaF-SF (200 and 400 mg/kg) manifested anxiolysis evidenced by higher exploration in elevated plus maze and hole board tests. Similarly, a dose-dependent drop of immobility time in a forced swimming test ensured significant anti-depressant activity. Moreover, higher dose treatment exposed reduced exploratory behaviour resembling decreased movement and prolonged sleeping latency with a quick onset of sleepduring the open field and thiopental-induced sleeping tests, respectively. Inparallel, EaF-SF significantly (p < 0.001) and dose-dependently suppressed aceticacid and formalin-induced pain in mice. Also, a noteworthy anti-inflammatoryactivity and a substantial (p < 0.01) clot lysis activity (thrombolytic) was observed. Gas chromatography-mass spectrometry (GC–MS) analysis resulted in 49 bioactive compounds. Among them, 12 bioactive compounds with Lipinski’s rule and safety confirmation showed strong bindingaffinity (molecular docking) against the receptors of each model used. Toconclude, the S. fruticosum seed isa prospective source of health-promotingeffects that can be an excellent candidate for preventing degenerative diseases.

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Section: Methodsmentioning

confidence: 99%

Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways

Moni

Adnan

Tareq

et al. 2021

Life

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“…Traditionally, the treatment of joint ache is used a fresh boiled bark juice extracted from this plant. Previous studies revealed that various phytochemicals isolated from this plant have significant analgesic (Singh et al 2008), anti-inflammatory (Ferreres et al 2017); anxiolytic, sedative, and antioxidant (Auniq et al 2021); anti-nociceptive and anthelmintic (Auniq et al 2019); antibacterial and antifungal activities (Panda et al 2012). Bark and leaves of V. peduncularis are also successfully used for the treatment of malaria, diabetes, and jaundice (Nag et al 2011).…”

Section: Received: 06 November 2022mentioning

confidence: 99%

Antioxidant, thrombolytic, cytotoxic and antibacterial activities of leaves of Vitex peduncularis

Mansur

Rakhi

et al. 2022

Bangladesh J. Sci. Ind. Res.

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Vitex peduncularis (Verbenaceae), a perennial tree, is locally utilized for possessing multifaceted pharmacological properties including analgesic, antimalarial, anti-angina, antidiabetic, antioxidant, anti-inflammatory and hepatoprotective. Hence, this study aims to evaluate their antioxidant, thrombolytic, cytotoxic and antibacterial activities from the methanolic crude extract and its various solvent fractions. Data from antioxidant and thrombolytic assay displayed that Kupchan partitioned chloroform soluble fraction revealed the maximum phenolic content (73.39 mg of GAE/g of extract), DPPH free radical scavenging activity (26.69 μg/ml) and thrombolytic activity (37.35%). In brine shrimp lethality evaluation, the LC50 values indicate that the most cytotoxic compound was found to be from ethyl acetate soluble fraction (LC50 6.73 μg/ml). Finally, antibacterial activity of different fractions showed that both chloroform and methanolic fraction possessed mild activity against the tested bacteria. The potential biological effects of the crude fractions have been demonstrated demanding future studies of the isolated compounds to assess these activities. Bangladesh J. Sci. Ind. Res. 57(4), 239-246, 2022

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“…Ex Schauer can be discovered in Bangladesh, India, Vietnam, and Myanmar. The plant is also natively called Horina in Chittagong, Korobaong in Bengali, Chang Xu Jing in China, and Charaiygoda in Hindi [ 64 ]. The traditional medicine system used various portions of V .…”

Section: Traditional Medicinal Use Of Vitex Speciesmentioning

confidence: 99%

“…In Bangladesh, different ethnic communities have employed Korobaong plant for different purposes. For example, the natives around the hill area of Khagrachari utilized the leaves and barks of the plant as a remedy for diabetes [ 64 ]. Meanwhile, the Chakma people made paste from the bark of the plant and topically used it for the treatment of jaundice and numbness of the face and eyes [ 64 , 65 ].…”

Section: Traditional Medicinal Use Of Vitex Speciesmentioning

confidence: 99%

“…For example, the natives around the hill area of Khagrachari utilized the leaves and barks of the plant as a remedy for diabetes [ 64 ]. Meanwhile, the Chakma people made paste from the bark of the plant and topically used it for the treatment of jaundice and numbness of the face and eyes [ 64 , 65 ]. They also used the same paste and took it with water to treat urethritis [ 9 ].…”

Section: Traditional Medicinal Use Of Vitex Speciesmentioning

confidence: 99%

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Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

Kamal

Asni

Rozlan

et al. 2022

Plants

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The genus Vitex is also known as a chaste tree, in which it is a large shrub native to the tropical and subtropical regions of the world. A diverse range of species is distributed throughout Southern Europe, the Mediterranean, and Central Asia. The Vitex tree, including its leaves and fruits, has been used for herbal remedies in the form of pastes, decoctions, and dried fruits since ancient times. This article aimed to prepare a comprehensive review of traditional uses and secondary metabolites derived from Vitex sp., including the chemical compounds, biological activities, application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents. The scientific findings were obtained using a number of search engines and databases, including Google Scholar, PMC, and ScienceDirect. Vitex species are well known in pharmacology to have medicinal values, such as anti-inflammatory, antibacterial, antifungal, antimicrobial, antioxidant, and anticancer properties. Previous studies reported that some species are proven to be effective in treating diseases, such as diabetes, and improving female health. A total of 161 compounds from different Vitex species are reported, covering the literature from 1982 to 2022. A chemical analysis report of various studies identified that Vitex exhibited a wide range of phytoconstituents, such as iridoid, diterpenoid, ecdysteroid, and flavonoid and phenolic compounds. Apart from that, the review will also discuss the application of Vitex in human clinical trials, toxicology and safety, marketed products, and patents of the genus. While the extracts of the genus have been made into many commercial products, including supplements and essential oils, most of them are made to be used by women to improve menstrual conditions and relieve premenstrual syndrome. Among the species, Vitex agnus-castus L. is the only one that has been reported to undergo clinical trials, mainly related to the use of the genus for the treatment of mastalgia, menstrual bleeding problems, amenorrhea, menorrhagia, luteal insufficiency, and premenstrual syndrome. Overall, the review addresses recent therapeutic breakthroughs and identifies research gaps that should be explored for prospective research work.

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Evaluation of anxiolytic, sedative, and antioxidant activities of Vitex peduncularis Wall. leaves and investigation of possible lead compounds through molecular docking study

Cited by 3 publications

References 42 publications

Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways

Therapeutic Potentials of Syzygium fruticosum Fruit (Seed) Reflected into an Array of Pharmacological Assays and Prospective Receptors-Mediated Pathways

Antioxidant, thrombolytic, cytotoxic and antibacterial activities of leaves of Vitex peduncularis

Traditional Medicinal Uses, Phytochemistry, Biological Properties, and Health Applications of Vitex sp.

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