Evaluation of anxiolytic effect of Syzygium aromaticum: a traditional herb of India

Tiwari, Prashant; Verma, Richa; Ahirwar, Dheeraj; Chandy, Anish; Dwivedi, Shubhangi

doi:10.1016/s2222-1808(14)60418-7

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…Since consensus of the max amount of eugenol that can be in a kretek is 2 mg, assuming that the average weight of a smoker is around 50-70 kg, even if he/ she smokes 10 sticks it will still be within the acceptable margin as WHO prescribe. [7,8] Based on the results we can see that group 1(CCl4+Clove3) has the highest catalase concentration activity. This result corresponds with the research of liver MDA concentration result run on the same rat subject that has the highest concentration on the day 3.…”

Section: Discussionmentioning

confidence: 93%

“…Clove itself contains eugenol, eugenol acetate, caryophyllene, flavonoid, and Betacaryophyllene which play an important role in warding off free radicals. [6][7][8][9][10][11] Research on clove antioxidant activity has been widely studied but no studies on clove effect induced by CCl4 in mice in the changes of carbonyl, malondialdehyde, and glutathione levels (reduced glutathione) in the liver. [12][13][14] Therefore, the question arises whether there is an effect of clove in the induction of CCl4 will changes in catalase activity in liver.…”

Section: Introductionmentioning

confidence: 99%

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Syzygium aromaticum (clove) effect on catalase activity due to carbon tetrachloride-induced oxidative stress in rat liver

Prijanti

Hawali

2018

actabioina

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Background: Clove is known as antioxidant spice that used in cigarettes, spice for food/soup, and traditional medicine. It is believed that clove could protect smokers from cigarette-free radicals. Otherwise, study on clove as an antioxidant was still confused.Objective: To reveal that clove can overcome carbon tetra chloride (CCl4) and its free radical derivesMethod: This study was an experimental research, using 20 Wistar rats that were divided into 4 groups, Group 1 (CCl4 + cloves 3), group 2 (CCl4 + cloves 1), group 3 (normal control, without being offered treatment), group 4 (positive control, induced by CCl4 and followed by 100 mg alpha-tocopherol), and group 5 (negative control, only induced by CCl4). Rat livers were homogenized and followed with CAT activity measurement using spectrophotometry method of Mates.Results: There was a significant difference in mean between the groups (p= 0,001). Further test, the Post Hoc showed that there is a significance different between group 1 and 4 (p=0.008), 1 and 5 (p=0.001), 2 and 5 (p=0.001), 3 and 5 (p=0.001), and 4 and 5 (p=0.007). Group 1 (CCl4+Clove3) has the highest catalase activity.Conclusion: Syzygium aromaticum (clove) oral administration with the dose of 200 mg/kg rat body weight against 0.55 mg/kgBW CCl4 show increased of catalase activity but did not overcome the oxidative stress.

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Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Syzygium aromaticum (clove) effect on catalase activity due to carbon tetrachloride-induced oxidative stress in rat liver

Prijanti

Hawali

2018

actabioina

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“…In particular, the physicochemical properties of the testing material, the use of realistic doses, appropriate routes of administration, and suitable statistical evaluations would enable proper data interpretation because high risks of bias could have an impact on the reliability and reproducibility of these findings (Butterweck & Nahrstedt, 2012; Rosso et al, 2022). Except for three studies (Ishaq, 2016; Manisha et al, 2013; Tiwari et al, 2014), most of the authors describe in the introduction the background that leads to a clear rationale for investigating the related activity in each species—either using an inverse approach from its ethnomedical uses, from previous results of pharmacological research, clinical trials, or knowledge of its mechanisms and phytochemical composition. However, we observed an overall low quality of reporting related to identifying behavioral data and blinding investigators, since 79% of researchers failed to report the method utilized.…”

Section: Discussionmentioning

confidence: 99%

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre‐clinical studies published from 2010 to 2020

Meneses

Valdés

Garrido-Suárez³

et al. 2023

Phytotherapy Research

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Anxiety disorders are prevalent conditions in the world population, whose standard approaches include pharmacotherapy, psychotherapy, and combinations of these interventions. Different classes of psychopharmaceuticals are recommended as the first line of drugs to treat these disorders, which can have several adverse effects, treatment resistance, dependence, and drug–drug interactions making it necessary to search for new therapeutic agents. In particular, diazepam (DZP), a prototype drug from the group of benzodiazepines, has been commonly used and evaluated for its efficacy and safety in different anxiety disorders in clinical trials. DZP is also the most widely used reference standard in in vivo pharmacological assays of natural compounds. However, translating the results obtained in different rodent species and physiological anxiety tests instead of psychopathological animal models that can be of clinical application remains challenging. A systematic review of scientific articles published between 2010 and 2020 that included in vivo pre‐clinical tests to define the anxiolytic, sedative and/or hypnotic effect of flower extracts is proposed. PRISMA and Rayyan were used for the selection of studies using four databases (Pubmed, Scopus, Web of Science, and QInsight), using the keywords: “Animals,” “Anxiolytic,” “Diazepam,” “Elevated Plus Maze,” “Flower Extracts,” “Insomnia,” “In vivo,” “Mice,” “Open Field Test,” “Pre clinical” and “Sedative.” The characteristics of anxiety studies in animal models, other studies related to locomotor activity, and the hypnotic effect of the extracts were compiled. Twenty‐four articles were included, 21 of them performed the animal model of anxiety‐like behavior of the elevated plus maze, seven the open field test, and six the light–dark box test. The locomotor activity was evaluated in 10 studies after the administration of the extracts to the animals to define their sedative effect, where only one defined that the extract (Matricaria chamomilla) had a sedative effect. The plants declared with this type of activity were Achyranthes aspera, Alcea aucheri, Brassica nigra, Cananga odorata, Carthamus tinctorius, Chrysanthemum indicum, Citrus aurantium, Couroupita guianensis, Echium amoenum, Erythrina berteroana, Gardenia jasminoides, Hibiscus tilliaceus, Lavandula officinalis, Lawsonia inermis, Matricaria chamomilla, Melia azedarach, Nerium oleander, Passiflora incarnata, Plumeria rubra, Salix aegyptiaca, Syzygium aromaticum, Tagetes erecta, Tilia americana. Although this review showed that some flower extracts have an anxiolytic effect as effective as diazepam, their therapeutic utility in anxiety disorders remains to be extensively demonstrated. Hence, more reliable and predictive behavioral tests and appropriate strategies for the experimental designs are needed to obtain more conclusive evidence with clinical significance.

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“…The EPM is an animal model of anxiety useful to predict the anxiolytic effects of benzodiazepines (BZD) [ 19 ]. Cyclooxygenase (COX) is reported to play an important role in pathogenesis of various neurodegenerative disorders including stroke and seizures [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

Hasan

Das

Mahmud

et al. 2016

Advances in Pharmacological Sciences

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Purpose. The present study was designed to investigate the antinociceptive, anxiolytic, CNS depressant, and hypoglycemic effects of the naproxen metal complexes. Methods. The antinociceptive activity was evaluated by acetic acid-induced writhing method and radiant heat tail-flick method while anxiolytic activity was evaluated by elevated plus maze model. The CNS depressant activity of naproxen metal complexes was assessed using phenobarbitone-induced sleeping time test and the hypoglycemic test was performed using oral glucose tolerance test. Results. Metal complexes significantly (P < 0.001) reduced the number of abdominal muscle contractions induced by 0.7% acetic acid solution in a dose dependent manner. At the dose of 25 mg/kg body weight p.o. copper, cobalt, and zinc complexes exhibited higher antinociceptive activity having 59.15%, 60.56%, and 57.75% of writhing inhibition, respectively, than the parent ligand naproxen (54.93%). In tail-flick test, at both doses of 25 and 50 mg/kg, the copper, cobalt, silver, and zinc complexes showed higher antinociceptive activity after 90 minutes than the parent drug naproxen. In elevated plus maze (EPM) model the cobalt and zinc complexes of naproxen showed significant anxiolytic effects in dose dependent manner, while the copper, cobalt, and zinc complexes showed significant CNS depressant and hypoglycemic activity. Conclusion. The present study demonstrated that copper, cobalt, and zinc complexes possess higher antinociceptive, anxiolytic, CNS depressant, and hypoglycemic properties than the parent ligand.

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Evaluation of anxiolytic effect of Syzygium aromaticum: a traditional herb of India

Cited by 9 publications

References 4 publications

Syzygium aromaticum (clove) effect on catalase activity due to carbon tetrachloride-induced oxidative stress in rat liver

Syzygium aromaticum (clove) effect on catalase activity due to carbon tetrachloride-induced oxidative stress in rat liver

Systematic review on the anxiolytic and hypnotic effects of flower extracts in in vivo pre‐clinical studies published from 2010 to 2020

Pharmacological Evaluation of Naproxen Metal Complexes on Antinociceptive, Anxiolytic, CNS Depressant, and Hypoglycemic Properties

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