Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

Cândida, Thamyris; França, Jerônimo Pereira de; Chaves, Agnaldo Rodrigues de Melo; Lopes, Fernanda Andrade Rodrigues; Gaiba, Silvana; Sacramento, Célio Kersul do; Ferreira, Lydia Masako; França, Lucimar Pereira de

doi:10.1590/s0102-86502014001400003

Cited by 10 publications

(8 citation statements)

References 13 publications

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“…Leaf, fruit and aerial part of M. citrifolia exhibit antimicrobial effect against Escherichia coli, Staphylococcus aureus, Candida albicans , Aspergillus niger, Pseudomonas aeruginosa, Proteus morgaii, Bacillus subtilis, Helicobacter pylori , Enterococcus faecalis , Salmonella and Shigella species (Jainkittivong et al, ; Candida et al, ; Choudhary et al, ; Dhivya, & Santhy, ; Chaitanya et al, ; Babaji, Jagtap, & Lau, ; Bhardwaj, Velmurugan, & Sumitha, ; Usha et al, ; Banerjee, Johnson, Csiszar, Wansley, & McGeady, ). The morinquinone isolated from the stems of M. elliptica possesses weak antimicrobial activity against S. aureus and a methicillin‐resistant S. aureus .…”

Section: Pharmacology Of Indian Morinda Speciesmentioning

confidence: 99%

“…The methanolic extract of the dried M. citrifolia fruit was found active to Penicillium, Fusarium and Rhizopus species (Jainkittivong et al, ) and C. albicans (Barani et al, ). The ethanolic extract of M. citrifolia L. fruit showed antimicrobial activity to S. aureus and E. coli (Candida et al, ). The acetonitrile extract, acubin, l‐asperuloside, alizarin and scopoletin isolated from dried fruits of M. citrifolia inhibit the growth of P. aeruginosa, B. subtilis, E. coli , Streptococcus pyrogene (Locher, Burch, Mower, et al, ), Salmonella, Shigella and E. coli (Dittmar, ).…”

Section: Pharmacology Of Indian Morinda Speciesmentioning

confidence: 99%

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Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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Morinda is a largest genus of Rubiaceae family, and its 11 species are found in India.In India, plant species are known by several common names as great morinda, Indian mulberry, noni, beach mulberry and cheese fruit. Various Morinda products (capsules, tablets, skin products and fruit juices) are available in the market, used by people for treatment of several health complaints. A diversity of phytochemicals including iridoids, flavonoids, flavonoid glycosides, anthraquinones, coumarins, lignanas, noniosides, phenolics and triterpenoids have been reported from Morinda species. Morinda species are used in the treatment of inflammation, cancer, diabetes, psyquiatric disorders, and bacterial and viral infections. The noni fruit juice (Morinda citrifolia) and its products are used clinically in the treatment of cancer, hypertension and cervical spondylosis affecting patients. M. citrifolia fuit juice, with different doses, is used in the maintaining blood pressure and reducing of superoxides, HDL and LDL levels. Similarly, oligosaccharide capsules and tablets of root extract of M. officinalis are recommended as medicine for the treatment of kidney problems and sexual dysfunctions of patients. The toxicological studies revealed that higher doses of fruit juice (4,000 or 5,000 mg/kg) of M. citrifolia for 2 or more months cause toxic effects on liver and kidneys. M. officinalis root extracts (ethanolic and aqueous) are found fully safe during treatment of diseases. A large number of reviews are available on M. citrifolia but very few studies are conducted on other Indian Morinda species. This review reports the comprehensive knowledge on state-wise distribution, botany, ethnomedicinal uses, phytochemistry, pharmacological activities, clinical applications and toxicological evaluations of 11 species of Morinda found in India.

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Section: Pharmacology Of Indian Morinda Speciesmentioning

confidence: 99%

Section: Pharmacology Of Indian Morinda Speciesmentioning

confidence: 99%

Indian Morinda species: A review

Singh

Sharma

2019

Phytotherapy Research

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“…The antiproliferative effect of the methanolic extract of noni fruit has been described in a number of cell lines, such as baby hamster kidney cells (BHK), African green monkey kidney cells (Vero), human epithelial type 2 cells (Hep2), human breast adenocarcinoma cells (MCF7) and neuroblastoma. The ethanolic extract was tested in B16‐F10 melanoma cells (LAN5) and also exhibited antiproliferative action (Arpornsuwan and Punjanon, ; Candida et al , ).…”

Section: Antitumor Activitymentioning

confidence: 99%

“…This reveals the usefulness of the fruit in production systems where antibiotic use is restricted (Schäfer et al , ). The ethanolic fruit extract also acts against E. coli and inhibits Staphylococcus aureus growth in vitro (Candida et al , ).…”

Section: Antibacterial and Anti‐septic Activitiesmentioning

confidence: 99%

One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia

Torres

Magalhães

Mondêgo-Oliveira

et al. 2017

Phytotherapy Research

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Morinda citrifolia, also known as noni, is commonly used in popular medicine in Brazil. Many parts of the noni tree are utilized in such practices, including the roots, leaves and seeds. Through a search of online databases, the present article reviews 92 research studies on the biological actions of M. citrifolia. The paper will discuss the therapeutic effects of noni and its compounds in a variety of forms of presentation, focusing on studies that support its traditional use. A large and diverse number of properties were identified, which were divided into immunostimulatory, antitumor, antidiabetic, anti-obesity, antibacterial and anti-septic, antifungal, antiviral, leishmanicidal, antiinflammatory, antinociceptive and analgesic, antioxidant, neuroprotective, wound healing, antiallergic, antiangiogenic, antiemetic and anti-nausea, anti-gastric ulcer and oesophagitis, anthelmintic, antimutagenic, antipsychotic, anxiolytic, photoprotective, anti-wrinkle and periodontal tissue regeneration activities. While it was concluded that although M. citrifolia is widely and successfully used for the treatment or prevention of various diseases, it should be consumed carefully, and only after exhaustive studies into its chemical constituents and mechanisms of action, both in in vitro and in vivo models, as well as clinical trials. Copyright © 2017 John Wiley & Sons, Ltd.

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“…Each part of the plant, from its roots to its seeds, is widely used in folk medicine, and several therapeutic effects have already been reported. 7 Biological actions of M. citrifolia include antioxidant, 8 immunostimulatory, 9 antitumor, 10 antidiabetic, 11 anti-obesity 12 antibacterial and anti-septic, 13,14 antifungal, 15 antiviral, 16 leishmanicidal, 17 anti-inflammatory, 18 antinociceptive and analgesic, 19 neuroprotective, 20 wound healing, 21 anti-allergic, 22 antiangiogenic, 23 antiemetic and anti-nausea, 24 anti-gastric ulcer and oesophagitis, 25 anthelmintic, 26 antimutagenic, 27 antipsychotic, 28 anxiolytic, 29 photo protective, 30 anti-wrinkle 31 and periodontal tissue regeneration activities 32 have been reported. In the present study, we hypothesized the beneficial effect of Noni (Morinda citrifolia L.) in reducing blood pressure in ovariectomized rats fed with high-fat diet.…”

Section: Introductionmentioning

confidence: 99%

Effect of Ethanolic Leaf Extract of Noni (Morinda Citrifolia L.) on Blood Pressure in Ovariectomized Rats Fed With High-Fat Diet

Othman¹

2017

MOJBOC

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Evaluation of antitumoral and antimicrobial activity of Morinda lcitrifolia L. grown in Southeast Brazil

Cited by 10 publications

References 13 publications

Indian Morinda species: A review

Indian Morinda species: A review

One Plant, Many Uses: A Review of the Pharmacological Applications of Morinda citrifolia

Effect of Ethanolic Leaf Extract of Noni (Morinda Citrifolia L.) on Blood Pressure in Ovariectomized Rats Fed With High-Fat Diet

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