Evaluation of antitrypanosomal and anti inflammatory activities of selected Nigerian medicinal plants in mice

Abstract

. AbstractThe extracts of nine selected Nigerian medicinal plants were investigated on Trypanosoma brucei brucei infected mice. The antiinflammatory properties of hexane fraction of the most promising U. chamae extract was assessed by acute oedema of the mice paw model while the modulatory effect of the extract on Delayed-Type Hypersensitivity (DTH) response on in vivo leucocytes mobilization was evaluated. 'Dose-probing acute toxicity tests' established an oral and intraperitoneal LD 50 for T. ivorensis stem bark as >1600 < 5000 mg/kg and 100 mg/kg respectively, while the oral LD 50 of Uvaria. chamae was >5000 mg/kg. Extracts of Khaya senegalensis, Harungana madagascariensis, Terminalia ivorensis, Curcuma longa, Ocimum gratissimum and Alcornea cordifolia showed weak anti-trypanosomal effect and did not exhibit significant clearance in parasitemia at the test dose administered compared with the positive control (Diminal®). However, the leaf extract of U. chamae and its hexane fraction demonstrated a significant response (P < 0.01). The fraction at 1000 mg/kg inhibited oedema by 107%. Uvaria. chamae demonstrated both antitrypanosomal and anti-inflammatory properties by increasing the survival time of infected mice due to reduction in parasitemia caused by T. brucei brucei.

Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria

“…Its fruit is edible and its roots show great interest throughout the world. Many activities have been assigned to this plant so far: antiparasitic [ 3 , 4 ], antiplasmodial [ 5 , 6 ], antidiabetic [ 7 , 8 ], anti-diarrheal [ 9 ], antifungal [ 10 , 11 ], anti-inflammatory [ 12 ], or antimalarial [ 13 , 14 ].…”

Haematological and Genotoxicity Evaluations of Phytochemical Compounds from n-Hexane Extract of Uvaria chamae Stem on Selected Organs in Mice

“…The leaf extracts of U. chamae have been reported to possess antibacterial (Oluremi et al, 2010), antifungal (Okwuosa et al, 2012), antispasmodic, anti-trypanosomal and anti-inflammatory (Adelodun et al 2013) properties. The roots of the plant have been reported to demonstrate antibacterial, antioxidant (Kone et al, 2015), anti-inflammatory, oxytocic (Okwu and Iroabuchi, 2009) and anti-sickling (Thierry et al, 2012) activities.…”

Antidiabetic and hypolipidemic activities of hydroethanolic root extract of Uvaria chamae in streptozotocin induced diabetic albino rats

“…The study showed that the hypoglycemic properties of Uvaria chamae may be accounted for by the presence of the phytochemicals [9]. The anti-fungal, anti-malarial and anti-inflammatory activities of Uvaria chamae have also been reported [11, 13, 14]. However, no scientific study has been conducted on the antidiabetic activity of this plant.…”