Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from<i> Uvaria chamae</i> Roots against Multidrug-Resistant Bacteria

Koudokpon, Hornel; Armstrong, Nicholas; Dougnon, Victorien; Fah, Lauris; Hounsa, Edna; Bankolè, Honoré; Loko, Frédéric; Chabrière, Éric; Rolain, Jean‐Marc

doi:10.1155/2018/1453173

Cited by 44 publications

(23 citation statements)

References 23 publications

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“…The compounds exhibited 100% growth inhibition ( Singh et al, 2018 ). In another study, three chalcones, diuvaretin, uvaretin, and isouvaretin, were investigated on their antibacterial activity, and the culture inhibition was only observed for Gram-positive germs ( Koudokpon et al, 2018 ). A series of ten chalcones and five new dihydrochromane–chalcone hybrids (189–203) were synthesized, and their antifungal activity was evaluated in vitro , and only two compounds had similar antifungal activity to that of the positive control ( Mellado et al, 2019 ).…”

Section: Preclinical Pharmacological Activities Of Chalconesmentioning

confidence: 99%

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

et al. 2021

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Chalcones are among the leading bioactive flavonoids with a therapeutic potential implicated to an array of bioactivities investigated by a series of preclinical and clinical studies. In this article, different scientific databases were searched to retrieve studies depicting the biological activities of chalcones and their derivatives. This review comprehensively describes preclinical studies on chalcones and their derivatives describing their immense significance as antidiabetic, anticancer, anti-inflammatory, antimicrobial, antioxidant, antiparasitic, psychoactive, and neuroprotective agents. Besides, clinical trials revealed their use in the treatment of chronic venous insufficiency, skin conditions, and cancer. Bioavailability studies on chalcones and derivatives indicate possible hindrance and improvement in relation to its nutraceutical and pharmaceutical applications. Multifaceted and complex underlying mechanisms of chalcone actions demonstrated their ability to modulate a number of cancer cell lines, to inhibit a number of pathological microorganisms and parasites, and to control a number of signaling molecules and cascades related to disease modification. Clinical studies on chalcones revealed general absence of adverse effects besides reducing the clinical signs and symptoms with decent bioavailability. Further studies are needed to elucidate their structure activity, toxicity concerns, cellular basis of mode of action, and interactions with other molecules.

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Section: Preclinical Pharmacological Activities Of Chalconesmentioning

confidence: 99%

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

et al. 2021

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“…Pharmacological Activities of Chalcones: The biological effects of chalcones were found to be dependent on the presence, the number and position of functional groups such as methoxy, glycosides, hydroxyl, halogens in both A and B rings 75 . They present a broad spectrum of biological activities such as antifungal 76 , antifilarial, larvicidal, anticonvulsant 66 , anticancer 77,78 , antiinflammatory 79 , neuroprotective 79 , antimalarial 80 , antibacterial 81 , antilipidemic 82 , antihyperglycemic 82 , antiviral 83 , antimycobacterial 84 , antiprotozoal (antileishmanial and antitrypanosoma) 85 , antiangiogenic 86 , antiplatelet 87 , anti-HIV 88 and Two chalconoids from the desert plant Pulicaria incisa prevented cell death by inhibiting reactive oxygen species (ROS) 89 . The chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A.…”

Section: Fig 3: Pharmacological Activities Of Chalconementioning

confidence: 99%

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2020

IJPSR

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Plants are a valuable source of secondary metabolites. Many phytochemicals are obtained from the plant sources that are used as valuable medicinal agents. Chalcones are one of the important secondary metabolites obtained from many edible plants like foods, vegetables, tea, spices and natural foodstuffs. Chalcones considered as obligate intermediated in flavonoid biosynthesis but they do not accumulate to an appreciable degree in most plants. Chalcones are a group of plant-derived polyphenolic compounds belonging to the flavonoids family that possess a wide variety of cytoprotective and modulatory functions, which may have therapeutic potential for multiple diseases. The largest number of natural chalcones has been isolated from species of the Leguminosae, Asteraceae and Moraceae families. Chalcone accumulating plants have often been used in traditional medicine and These chalcones and their derivatives have shown important antimicrobial, antifungal, anti-mycobacterial, antimalarial, antiviral, antiinflammatory, antioxidant, anti-tumor, antileishmanial, anticancer properties. The purpose of this review is to summarize the various naturally occurring chalcone compounds which have been isolated from different plants and to describe the recent efforts of scientists in a pharmacological screening of chalcones, studying importance of chalcones and their biological activities. INTRODUCTION: Chalcones are a group of phenolic or flavonoid compounds widely distributed in plant kingdom 1. They are both intermediates and end products in flavonoid synthesis, act as defensive compounds, participated in pathogens interactions and contribute to the medicinal value of herbs 2. Naturally occurring chalcones and their synthetic derivatives show a wide spectrum of biological activities 3. For these reasons, chalcones are an object of continuously growing interest amongst scientists 4 .

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“…The control sample was prepared using the same volume without any compound and BHT, 95% methanol served as blank. Test was performed in triplicate and the results were averaged [32][33][34][35][36]. Radical scavenging activity was calculated using the formula:…”

Section: Antioxidant Activity Free Radical Scavenging Activity By Dppmentioning

confidence: 99%

In silico toxicity prediction, synthesis, characterization, antimicrobial and antioxidant activity of different di substituted chalcones

2020

Lett Appl NanoBioSci

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Right now the amalgamation of novel arrangement of 4'- chloro-3'- nitro-phenyl-(3-keto-1,2diene-1-flurobenzene), 4'- chloro-3'nitro-phenyl-(3-keto-1,2diene-1-chlorobenzene),4'- chloro-3'- nitro-phenyl-(3-keto-1,2diene-1-thiophene),4'- chloro-3'nitro-phenyl-(3-keto-1,2diene-1-pyridine), 4'- chloro-3'nitro-phenyl-(3-keto-1,2diene-1-furon).The target mixes were integrated by the Claisen-schimidt buildup utilizing corrosive and base as a response impetus. insilico enhancement strategies by utilization of various information base like molinspiration for atomic properties, bioactivity, ochem for organic information, pre ADME for pharmacokinetic properties, preToxicity for harmfulness profile of the mixes, swiss ADME for pharmacokinetic property, Swiss lethality for natural danger of the mixes, and Osiris(datawarrior) for poisonous quality forecast for dynamic lead particles ID. From the outcome mixes indented as dynamic leads they used to assess distinctive organic action. The mixes additionally finish the amees assessment for the most part for mutagenecity discovery that mixes shows mutagencity towards the test living being they likewise safe to hinder cytochrome P450 compound subunits like cyp1A2, cyp2C9, cyp2C19 which are situated in endoplasmic reticulum. Alpha beta unsaturated chalcones have fantastic cell reinforcement and antimicrobial action so the orchestrated mixes were screened for their antimicrobial by utilizing five bacterial strains and three parasitic strains and cancer prevention agent action by DPPH technique. From hostile to oxidant results compound 3a, 3b, 3c show critical action the measure esteems are closer to standard medication esteem. Antimicrobial movement results the compound 3a, 3c, 3e indicated noteworthy action against Bacillus subtilis, E Coli, Salmonella tyhphi, Pseudomonas aeruginosa though the compound 3b, 3d demonstrated moderate activitycompared to standard medication vale. Compound 3b, 3d demonstrated fantastic antifungal action against Candida albicans, Aspergillusniger, Alternariaalternata. The mixes 3a, 3c, 3e show moderate antifungal movement when contrasted with standard worth.

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Antibacterial Activity of Chalcone and Dihydrochalcone Compounds from Uvaria chamae Roots against Multidrug-Resistant Bacteria

Cited by 44 publications

References 23 publications

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

Pharmacological Properties of Chalcones: A Review of Preclinical Including Molecular Mechanisms and Clinical Evidence

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In silico toxicity prediction, synthesis, characterization, antimicrobial and antioxidant activity of different di substituted chalcones

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