Evaluation of antipyretic activity of ethyl acetate extract of Adenema hyssopifolium G. Don in a rat model

Pharmacognostical, phytochemical and pharmacological evaluation for the antipyretic effect of the seeds of Saraca asoca Roxb.

“…Pharmacognostical studies and determination of different physiochemical parameters are very much essential for the standardization of drug and establishing its pharmacological efficacy. Hence, these studies help in identification and authentication of the plant material [22][23][24][25][26][27] . The acetone extract of the seed was also evaluated for its antipyretic activity on the basis of phytoconstituents present in it.…”

“…Swiss albino mice of either sex, weighing about [20][21][22][23][24][25][26][27][28][29][30] g and albino (Wistar) rats of either sex, weighing about 120-150 g were used for in-vivo evaluation. All 27.03.08).…”

Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

“…The effect of EEAB at 20 mg/kg was found to be slightly more than that of aspirin after 6 h of treatment (Table 1). Table 1 also summarized the effect of EEAB (5,10,20 mg/ kg) and aspirin on formaldehyde induced arthritis. EEAB significantly suppressed the joint oedema when compared with control between day 2 and day 10 post formaldehyde Table 2 showed the time course of oedema due to CFA and inhibition rate after the administration of EEAB.…”

“…prostaglandin E2 (PGE2), prostaglandin D2 (PGD2), prostacycline (PGI2) and thromboxane A2 (TxA2). Eicosanoids are derived from polyunsaturated fatty acid arachidonic acid (AA; 20:4, n-6) by action of COX-1 and COX-2 [14][15][16][17][18][19][20] . PGE2 depresses the humoral antibody response by inhibiting the differentiation of B-lymphocytes into antibody secreting plasma cells.…”

“…The left footpad of each rat was injected subcutaneously with 0.05 mL (0.5% w/v) of CFA. Different groups of animal (n=6) received control vehicle (normal saline, 3 mL/kg), EEAB (5,10,20 mg/ kg, i.p.) and standard drug (aspirin, 100 mg/kg, i.p.…”