Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

Kaithwas, Gaurav; Gautam, Raju; Jachak, Sanjay M.; Saklani, Arvind

doi:10.1016/s2221-1691(12)60039-2

Cited by 54 publications

(41 citation statements)

References 19 publications

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“…To inspect the anti-arthritic effect of B. calliobotrys against turpentine oil induced joint edema method described by Kaithwas et al, 2012 was employed. Sprague-Dawley rats of either sex were fasted for a period of 24 hours before the commencement of experiment however; the animals were allowed free access to water.…”

Section: Turpentine Oil Induced Joint Edema In Ratsmentioning

confidence: 99%

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Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys

Alamgeer

Hasan

Uttra

et al. 2015

Bangladesh J Pharmacol

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The present study was commenced to evaluate the anti-arthritic effect of 70% methanol extract and n-butanol and aqueous fractions of Berberis calliobotrys using both in vitro and in vivo arthritis models. Extract and fractions were investigated in vitro for inhibition of protein (bovine serum and egg albumin) denaturation and human red blood cell membrane stabilization. In vivo anti-arthritic activity of extract and fractions at 50, 100 and 200 mg/kg was assessed using turpentine oil and formaldehyde-induced arthritis, while, 200 mg/kg dose was evaluated against complete Freund’s adjuvant-induced arthritis. B. calliobotrys produced significant (p<0.001) dose dependent inhibition of protein denaturation and human red blood cell membrane stabilization. In turpentine oil, formaldehyde and complete Freund’s adjuvant-induced arthritis models, B. calliobotrys significantly (p<0.001) reduced joint and paw swelling. B. calliobotrys markedly improved body weight, hematology profile, radiological and histopathological parameters in complete Freund’s adjuvant model. It could be concluded that B. calliobotrys holds anti-arthritic potential, supporting its traditional use in treatment of rheumatoid arthritis.

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Section: Turpentine Oil Induced Joint Edema In Ratsmentioning

confidence: 99%

“…The aspire of this experiment was to seek out the antiarthritic effect of B. calliobotrys against formaldehydeinduced chronic non-immunological arthritis in rats as illustrated by Kaithwas et al (2012). Sprague-Dawley rats of either sex were distributed into 11 groups of 5 rats each at random.…”

Section: Formaldehyde Induced Arthritis In Ratsmentioning

confidence: 99%

Evaluation of in vitro and in vivo anti-arthritic potential of Berberis calliobotrys

Alamgeer

Hasan

Uttra

et al. 2015

Bangladesh J Pharmacol

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“…NS non-significant, UFD umbelliferone diglucoside, CFA complete fruend's arthritic * P<0.05 is considered as significant ** P<0.01 is considered as very significant *** P<0.001 is considered as extremely significant is used with a relatively high degree of validity for evaluating agents with potential antiarthritic activity. Swelling in the hind paw is the primary reaction; characterized feature of the CFA induced arthritis which persisted for weeks and primary reaction followed by the development of the arthritic nodules in ear and tails and swelling in the contra lateral, this is called delayed response (secondary reaction) (Kaithwas et al 2012). CFA induced arthritic control group rats showed an increase the paw joint diameter till the day 28, which can be attributed to the delayed immunological flare in the disease (Pearson and Wood 1959).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside on adjuvant-induced arthritic rats

Kumar

Anwar²,

Verma

et al. 2014

J Food Sci Technol

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The aim and objective of the present investigation was to evaluate the antiarthritic and antioxidant effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside (UFD) in chemically induced arthritic rats. The different doses of the UFD were tested against the turpentine oil (TO), formaldehyde induced acute arthritis and complete fruend's adjuvant (CFA) induced chronic arthritis in Wistar rats. Arthritic assessment and body weight was measured at regular interval till 28 days. On day 28, all the groups animals were anaesthetized, blood were collected from the puncturing the ratro orbital and estimated the hematological parameters. The animals were sacrificed; synovial tissue was extracted and estimated the malonaldehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx) and superoxide dismutase (SOD). The different doses of the UFD showed the protective effect against turpentine oil, formaldehyde induced acute arthritis and CFA induced chronic arthritis at dose dependent manner. Acute model of arthritis such as TOand formaldehyde induced inflammation due to releasing of the inflammatory mediators; significantly inhibited by the UFD at dose dependent manner. CFA induced arthritic rats treated with the different doses of the UFD showed the inhibitory effect on the delayed increase in joint diameter as seen in arthritic control group rats. UFD significantly improved the arthritic index, body weight and confirmed the antiarthritic effect. UFD showed the effect on the hematological parameter such as improved the level of the RBC, Hb and decline the level of the EBC, ESR and confirmed the immune suppressive effect. UFD significantly improved the level of the endogenous antioxidant and confirmed the antioxidant effect. This present investigation suggests that the UFD has prominent antiarthritic impact which can be endorsed to its antiarthritic and antioxidant effects.

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“…[32] Similarly, Swertiamarin attenuates inflammation mediators via modulating NFκB/IkB and JAK STAT3 transcription factors in adjuvantinduced arthritis, [33] Celery seeds also show anti-arthritic activity. [34] Tinospora cordifolia, [35] Terminalia chebula Retz, [36] and Ajuga bracteosa Wall ex Benth [37] and Lakshadi Guggul showed strong anti-arthritic potential in albino rats [ Table 1]. [38] A regular treatment significantly reduces both the arthritic index (AI) and the CIA incidence.…”

Section: Nutraceuticalsmentioning

confidence: 99%

Untitled

Upadhyay

2016

IJGP

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The present review explains reasons of arthritis a disease related to chronic joint pain and inflammation. It also emphasizes the use of bioactive principles of plant origin to be used to relieve from arthritic pain, aching, stiffness, and swelling. These plant natural products can finish rheumatic pain if they are used regularly according to physician' advice. There are so many active crude extracts and pure compounds which show anti-arthritic activity in Freund's complete adjuvant induced animal models. Certain Ayurvedic formulations also assist to relieve from rheumatic arthritic pain and tone up immune system to function normally. This article shows an overview of medicinal suggestions on the basis of experimental advances made in the herbal medicinal researches in recent years for the treatment of arthritis. There are various dietary supplements which could also provide for management of severe pain of joints, and mitigation of inflammation. It is also suggested that early diagnosis, proper treatment, and healthy dietary habits can reduce the disease spectrum and chronic inflammatory pain.

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Antiarthritic effects of Ajuga bracteosa Wall ex Benth. in acute and chronic models of arthritis in albino rats

Cited by 54 publications

References 19 publications

Evaluation of <i>in vitro</i> and <i>in vivo</i> anti-arthritic potential of <i>Berberis calliobotrys</i>

Evaluation of <i>in vitro</i> and <i>in vivo</i> anti-arthritic potential of <i>Berberis calliobotrys</i>

Therapeutic effect of umbelliferon-α-D-glucopyranosyl-(2I→1II)-α-D-glucopyranoside on adjuvant-induced arthritic rats

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