Evaluation of Antiproliferative Palladium(II) Complexes of Synthetic Bisdemethoxycurcumin Towards in Vitro Cytotoxicity and Molecular Docking on DNA Sequence

Abstract

Metallodrugs form a large family of therapeutic agents against cancer, among which is cisplatin, a paradigmatic member. Therapeutic resistance and undesired side effects to Pt(II) related drugs, prompts research on different metal–ligand combinations with potentially enhanced biological activity. We present the synthesis and biological tests of novel palladium(II) complexes containing bisdemethoxycurcumin (BDMC) 1 and 2. Complexes were fully characterized and their structures were determined by X-ray diffracti…