Evaluation of antioxidant potential of Amalakayas Rasayana: A polyherbal Ayurvedic formulation

Abstract

Amalakayas Rasayana (AR) is a polyherbal formulation mentioned in Ayurveda to treat aging and age-associated diseases. Being an antiaging drug, AR may have antioxidants and free radical scavenging activity to minimize free radical-induced damage which is a key cause of aging. The methanolic extract of AR was evaluated in vitro for total phenolic and tannin content, free radical scavenging activity, superoxide radical scavenging activity, and reducing power. The total phenolic content was measured using Folin-ciocalteu reagent against gallic acid [relative standard deviation (R2) = 0.998]. Total tannin was estimated using the Stephen method and was found to be 2.82% w/w. Free radical scavenging activity was measured by 2,2-diphenyl-1-picryl hydrazyl assay and R2 was 1. Superoxide radical scavenging activity was done by ethylene diamine tetra acetate and Nitro Blue Tetrazolium Chloride assays against ascorbic acid and R2 was 0.976 (EC50= 77.5 μg/ml). Ferrous reducing power was evaluated by Oyaizu method where R2 was 0.986. All studies showed that AR possesses antioxidant activity. The results of this study suggest that the antioxidant and free radical scavenging activity of AR may explain its rasayana effect and justify its use as a medicine for age associated diseases.

Oxidative Stress and Cancer: Chemopreventive and Therapeutic Role of Triphala

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Synthesis and Antioxidant Properties of New Substituted 8‐Methyl‐6‐phenyl‐5,6‐dihydro‐4H‐1,3,2‐benzodioxaphosphocine‐2‐oxide Derivatives

“…p-Cresol (1) and cinnamic acid (2) were condensed in the presence of con. H 2 SO 4 under nitrogen atmosphere at 120°C for a period of 6 h to afford 3,4-dihydro-6-methyl-4-phenyl-2H-benzopyran-2-one (3).…”

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Effect of Amalaki rasayana on DNA damage and repair in randomized aged human individuals

“…However, there are several anecdotal claims which remain to be comprehensively tested through contemporary knowledge. The fruit extracts have been reported to possess antioxidant 5 (Samarakoon et al, 2011), immunomodulatory (Madhuri et al, 2011), anti-helminthic (Dwivedi et al, 2011), antimicrobial (Mehrotra et al, 2010;Saeed and Tariq, 2007), chondro-protective (Sumantran et al, 2008), anti-inflammatory (Sharma et al, 2003), antitumor (Jose et al, 2001) and memory enhancing (Ashwlayan and Singh, 2011) activities. It is also reported to be useful in the lowering of cholesterol, neutralizing snake venom and ophthalmic disorders (Khan, 2009).…”