Evaluation of antioxidant potencial of novel CaAl and NiAl layered double hydroxides loaded with olanzapine

Neto, João Gomes Pontes; Fontes, Danilo Augusto Ferreira; Lyra, Magaly Andreza Marques de; Brito, Maria dos Remédios Mendes de; Chaves, Luíse L.; Rolim-Neto, Pedro José; Soares, Mônica Felts de La Roca; Quintans‐Júnior, Lucindo José; Freitas, Rivelilson Mendes de; Sobrinho, José Lamartine Soares

doi:10.1016/j.lfs.2018.05.031

Cited by 10 publications

(5 citation statements)

References 45 publications

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“…Olanzapine (OLZ), 2-methyl-4-(4-methyle-1piperazinyl)-10H-thieno(2,3b)(1,5) benzodiazepine (37,38), is a second-generation atypical antipsychotic drug approved by the Food and Drug Administration (FDA) as a first-line therapy for the treatment of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia (39)(40)(41)(42)(43). Schizophrenia is a severe and chronic psychotic disorder, considered the most disabling psychiatric disorders with enormous economic and social impact (44).…”

Section: Introductionmentioning

confidence: 99%

“…OLZ is known to bind and antagonize copious receptors such as dopamine (D1, D2, D3, and D4); 5HT2 a , 5HT2 c , 5HT3, and 5HT6; histamine at H1 receptors; and alpha-1 adrenergic receptors (38,45,46) . Despite its vast applications in psychotic disorders, OLZ have an issue of poor water solubility that leads to unreliable absorption and erratic pharmacokinetic profiles (41,47). Therefore, the need to develop appropriate drug delivery system for efficient schizophrenia therapy is vital.…”

Section: Introductionmentioning

confidence: 99%

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RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

2020

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Current study is focused to enhance the solubility of poorly soluble drug olanzapine (OLZ) by nanogels drug delivery system, as improved solubility is one of the most important applications of nanosystems. Poor solubility is a major issue, and 40% of marketed and about 75% of new active pharmaceutical ingredients are poorly water soluble which significantly affect the bioavailability and therapeutic effects of these drugs. In this study, nanogels, a promising system for solubility enhancement, were developed by freeradical polymerization technique. Different formulations were synthesized in which poloxamer-407 was cross-linked with 2-acrylamido-2-methylpropane sulfonic acid (AMPS) with the help of cross-linker methylene bisacrylamide (MBA). The chemically cross-linked nanogels were characterized by Fourier transform infrared spectroscopy (FT-IR), thermos gravimetric analysis (TGA), differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta size, swelling, sol-gel analysis, drug loading, solubility, and in vitro drug release studies. In order to determine the biocompatibility and cytotoxicity of nanogels to biological system, toxicity study on rabbits was also carried out. It was confirmed that the developed nanogels was thermally stable, safe, effective, and compatible to biological system, and the solubility of olanzapine (OLZ) was enhanced up to 38 folds as compared with reference product.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

2020

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“…These processes result in an increase in oxidative, nitrosative, and sulfuric damage, which may include impaired glucose metabolism and the associated loss of ion gradients depending on functional potential disturbances and Ca 2+ transport [144]. During oxidative stress, there is an intracellular increase in free Ca 2+ levels, which are known to have unfavorable consequences, including depolarization of mitochondrial membranes, oxidative phosphorylation disorders, and overproduction of free radicals.…”

Section: Oxidative Nitrosative and Sulfuric Stress In Schizophreniamentioning

confidence: 99%

Oxidative-Antioxidant Imbalance and Impaired Glucose Metabolism in Schizophrenia

et al. 2020

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Schizophrenia is a neurodevelopmental disorder featuring chronic, complex neuropsychiatric features. The etiology and pathogenesis of schizophrenia are not fully understood. Oxidative-antioxidant imbalance is a potential determinant of schizophrenia. Oxidative, nitrosative, or sulfuric damage to enzymes of glycolysis and tricarboxylic acid cycle, as well as calcium transport and ATP biosynthesis might cause impaired bioenergetics function in the brain. This could explain the initial symptoms, such as the first psychotic episode and mild cognitive impairment. Another concept of the etiopathogenesis of schizophrenia is associated with impaired glucose metabolism and insulin resistance with the activation of the mTOR mitochondrial pathway, which may contribute to impaired neuronal development. Consequently, cognitive processes requiring ATP are compromised and dysfunctions in synaptic transmission lead to neuronal death, preceding changes in key brain areas. This review summarizes the role and mutual interactions of oxidative damage and impaired glucose metabolism as key factors affecting metabolic complications in schizophrenia. These observations may be a premise for novel potential therapeutic targets that will delay not only the onset of first symptoms but also the progression of schizophrenia and its complications.

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“…55% maximum effect, which is very similar, if not slightly higher than bare Irganox 1425. The LDH hybrid of olanzapine (2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno [2,3-b] [1,5]-benzodiazepine) was also developed to overcompensate its low water solubility [123]. This drug molecule is a popular antipsychotic agent and due to the correlation between oxidative stress and brain damage [168], its antioxidant potential may be a reason for its pharmaceutical efficacy.…”

Section: Layered Double Hydroxides (Ldhs)mentioning

confidence: 99%

Antioxidant Materials Based on 2D Nanostructures: A Review on Recent Progresses

et al. 2020

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Counteracting reactive oxygen species (ROS, e.g., superoxide radical ion, H2O2 and hydroxyl radical) is an important task in fighting against oxidative stress-related illnesses and in improving product quality in industrial manufacturing processes. This review focuses on the recent advances on two-dimensional (2D) nanomaterials of antioxidant activity, which are designed for effective decomposition of ROS and thus, for reduction of oxidative stress. Some materials featured in this paper are of uni- or multi-lamellar structures modified with small molecular or enzymatic antioxidants. Others are enzyme-mimicking synthetic compounds (the so-called nanozymes) prepared without antioxidant additives. However, carbon-based materials will not be included, as they were extensively reviewed in the recent past from similar aspects. Given the landmark development around the 2D materials used in various bio-applications, sheet-like antioxidant compounds are of great interest in the scientific and technological communities. Therefore, the authors hope that this review on the recent progresses will be helpful especially for researchers working on novel developments to substantially reduce oxidative stress either in biological systems or industrial liquors.

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Evaluation of antioxidant potencial of novel CaAl and NiAl layered double hydroxides loaded with olanzapine

Cited by 10 publications

References 45 publications

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

RETRACTED ARTICLE: Poloxamer-407-Co-Poly (2-Acrylamido-2-Methylpropane Sulfonic Acid) Cross-linked Nanogels for Solubility Enhancement of Olanzapine: Synthesis, Characterization, and Toxicity Evaluation

Oxidative-Antioxidant Imbalance and Impaired Glucose Metabolism in Schizophrenia

Antioxidant Materials Based on 2D Nanostructures: A Review on Recent Progresses

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