Antioxidant Materials Based on 2D Nanostructures: A Review on Recent Progresses

Abstract

Counteracting reactive oxygen species (ROS, e.g., superoxide radical ion, H2O2 and hydroxyl radical) is an important task in fighting against oxidative stress-related illnesses and in improving product quality in industrial manufacturing processes. This review focuses on the recent advances on two-dimensional (2D) nanomaterials of antioxidant activity, which are designed for effective decomposition of ROS and thus, for reduction of oxidative stress. Some materials featured in this paper are of uni- or multi-lamellar structures modified with small molecular or enzymatic antioxidants. Others are enzyme-mimicking synthetic compounds (the so-called nanozymes) prepared without antioxidant additives. However, carbon-based materials will not be included, as they were extensively reviewed in the recent past from similar aspects. Given the landmark development around the 2D materials used in various bio-applications, sheet-like antioxidant compounds are of great interest in the scientific and technological communities. Therefore, the authors hope that this review on the recent progresses will be helpful especially for researchers working on novel developments to substantially reduce oxidative stress either in biological systems or industrial liquors.

Design of hybrid biocatalysts by controlled heteroaggregation of manganese oxide and sulfate latex particles to combat reactive oxygen species

“…4,6,7 In this way, nanomaterials possessing antioxidant activities have been widely explored in attempt to replace natural radical scavenging enzymes. [8][9][10][11] Since the early reports on superoxide dismutase (SOD) mimicry by fullerene derivatives, 12,13 extensive research has been reported in the literature on various antioxidant nanozymes of diverse structures and catalytic roles. 4,6 These include metallic nanoparticles such as Ag, 14 Au, 15 Pt, 16 and Pd; 17 metal oxides including Co 3 O 4 , 18 CeO 2 , 9,19 and CuO 20 nanospheres as well as V 2 O 5 nanowires; 21 metal chalcogenides such as FeS, 22 MoSe 2 , 11 MoS 2 , 23 and WS 2 24 nanosheets; carbon derivatives like fullerenes, carbon nanotubes, nanodots and metal-organic frameworks.…”

Curcumin Incorporation into Zn3Al Layered Double Hydroxides—Preparation, Characterization and Curcumin Release

“…An interesting feature of the LDHs is the so-called "memory effect" which allows the reconstruction of the layered structure when the mixed oxide obtained by thermal decomposition of an LDH precursor at temperatures lower than 550 • C is immersed in an aqueous solution containing the desired compensation anion which can be either inorganic or organic [21,22]. LDH compounds are considered to have low toxicity, good biocompatibility and a buffering action when immersed in aqueous solutions, therefore they were also utilized in medical formulations (such as the antiacid TALCID ® ), for ibuprofen slow release, in colon-targeted drug-delivery, for anticancer methotrexate delivery [25][26][27][28] and as matrices for bioinorganic hybrid materials [29][30][31]. Due to their structure LDHs compounds have anion exchange properties and are frequently utilized as anion exchangers and adsorbents.…”

Layered double hydroxide-based antioxidant dispersions with high colloidal and functional stability

“…To deal with these issues, the development of nanocomposites of antioxidant substances with solid supports were the focus of research groups in the past. 14 As solid carriers, various compounds have been considered, e.g., titanium dioxide, 15,16 graphene oxide, 17,18 aluminosilicates 19,20 and layered double hydroxides (LDHs). [21][22][23] The latter substances offer a large selection of materials that can be perceived as mixed metal hydroxides containing divalent and trivalent cations.…”