Evaluation of antioxidant defense markers in relation to hormonal and insulin parameters in women with polycystic ovary syndrome (PCOS): A case-control study

Fatima, Qudsia; Amin, Shajrul; Kawa, Iram Ashaq; Jeelani, Humira; Manzoor, Saika; Rizvi, Syeed Masuma; Rashid, Fouzia

doi:10.1016/j.dsx.2019.04.032

Cited by 30 publications

(15 citation statements)

References 37 publications

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“…As mentioned in the introduction, women-specific cardiovascular risk can also be associated with other comorbidities, e.g., polycystic ovary syndrome (PCOS), which is, additionally, associated with obesity [92]. For example, in the study of Fatima et al, subjects with PCOS had poor antioxidant status e reflected by, among others, significantly low concentration of vitamin E À which suggests that women with PCOS are under oxidative stress, which could additionally increase future CV risk [93]. Moreover, in the study of Shirazi et al on women with PCOS, 8-weeks of vitamin E supplementation (400 IU/day) resulted in a significant reduction in angiogenic indices, such as Angiopoietin(Ang)-1, Ang-1/Ang-2 ratio, and vascular endothelial growth factor (VEGF) [94].…”

Section: Cardiovascular Riskmentioning

confidence: 99%

Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity – A narrative review

et al. 2022

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Section: Cardiovascular Riskmentioning

confidence: 99%

Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity – A narrative review

et al. 2022

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“…Inflammation results in the production of reactive oxygen species. Therefore, the studies indicated that the incidence of PCOS was closely related to oxidative stress and chronic low grade inflammation (44,45). In the present research, MDA is an indicator of lipid peroxidation that significantly increased in polycystic ovaries and red clover is able to restore it.…”

Section: Resultsmentioning

confidence: 49%

Therapeutic efficacy of Trifolium pratense L. on letrozole induced polycystic ovary syndrome in rats

et al. 2020

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Polycystic ovary syndrome (PCOS) is considered as one of the leading endocrine disorders during reproductive age in women. This study designed to determine the therapeutic effects of red clover (Trifolium pratense) on letrozole-induced PCOS in vivo. Forty female Sprague–Dawley rats were equally divided into five groups. Control group with a regular sexual cycle received normal saline (letrozole vehicle). Letrozole (1 mg/kg) was used to induce the PCOS to the rats in the treatment groups. After induction of PCOS, four treatment groups received the normal saline, or clomiphene citrate (1 mg/kg), or red clover extracts (500 or 750 mg/kg) for 30-days. After treatment, ovary and uterus were removed, weighed, and the ovaries were subjected to histopathological studies. Serum testosterone and estradiol levels, antioxidant activities, and lipid profiles were evaluated. Red clover extracts and clomiphene citrate decreased testosterone levels and showed a significant increase in estradiol levels in comparison to PCOS induced group (p<0.05). Red clover administration restored the GSH, SOD and CAT levels (p<0.05) and decreased the NO and MDA levels (p<0.05). Treatments caused no significant change in levels of TG, TC, and FBG factors when compared to PCOS induced group (P>0.05). However, red clover (750 mg/kg) significantly increased HDL and decreased LDL levels when compared to PCOS induced group (P<0.05). Treatment with red clover reduced ovarian weight, volumes of ovarian, medulla, cortex and number of cysts and increased number of oocytes compared to PCOS group. Both red clover and clomiphene citrate could treat the letrozole induced PCOS in rats; however, red clover indicated antioxidant activities more than clomiphene citrate. Red clover may be used for discovering anti-PCOS drugs with lower side effects.

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“…In the PCOS population, there are well-known significantly increased levels of ICAM-1 [ 6 , 7 ], MCP-1 [ 36 , 37 ], TNF-α [ 13 , 14 ] and PAI-1 [ 17 , 18 ] compared to the control group, which represents the early signs of macrovascular problems in these women. One of our recent studies reported that PCOS women have a lower antiinflammatory profile interleukin-10(IL-10) and adiponectin and non-enzymatic antioxidant characteristics than healthy participants [ 38 , 39 ].…”

Section: Discussionmentioning

confidence: 99%

Oral contraceptive pill (OCP) treatment alters the gene expression of intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1) in polycystic ovary syndrome (PCOS) women compared to drug-naive PCOS women

Yousuf

Ganie

Urwat³

et al. 2023

BMC Women's Health

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Background Polycystic ovary syndrome (PCOS) presents clinical symptoms of menstrual abnormalities, excessive hair growth (hirsutism), scalp hair loss, acne and infertility. Metabolic abnormalities such as obesity, insulin resistance, glucose intolerance and cardiovascular problems constitute an essential part of PCOS, all of which can have significant long-term health consequences. Low-grade chronic inflammation demonstrated by persistent moderately elevated serum levels of inflammatory and coagulatory markers plays a critical role in the pathogenesis of PCOS. Oral contraceptive pills (OCPs) constitute the mainstay of pharmacologic therapy for women with PCOS to regularize cyclicity and ameliorate androgen excess. On the other hand, OCP use is associated with various venous thromboembolic and proinflammatory events in the general population. PCOS women always carriers the increased lifetime risk of these events. The studies on the effect of OCPs on inflammatory, coagulation and metabolic parameters in PCOS are less robust. Therefore in this study, we investigated and compared the messenger RNA (mRNA) expression profiles of genes implicated in inflammatory and coagulation pathways between drug-naive and OCP-treated PCOS women. The selected genes include intercellular adhesion molecule-1 (ICAM-1), tumor necrosis factor-α (TNF-α), monocyte chemoattractant protein-1 (MCP-1) and plasminogen activator inhibitor-1 (PAI-1). Furthermore, the correlation between the selected markers and various metabolic indices in the OCP group has also been explored. Method The relative amounts of ICAM-1, TNF-α, MCP-1 and PAI-1 mRNA in peripheral blood mononuclear cells from 25 drug-naive PCOS subjects (controls) and 25 PCOS subjects who received OCPs containing 0.03 mg-ethinyl-estradiol and 0.15 mg-levonorgestrel for at least six months (cases) were estimated using real-time qPCR. The statistical interpretation was conducted using SPSS version 20.0 (SPSS, Inc, Chicago, IL), Epi Info version 2002 (Disease Control and Prevention Centres, Atlanta, GA) and GraphPad Prism 5 (GraphPad Software, La Jolla, CA) software. Result Six months of OCP therapy enhanced the expression of inflammatory genes viz ICAM-1, TNF-α and MCP-1 mRNA in PCOS women by 2.54, 2.05 and 1.74 folds, respectively, in this study. However, PAI-1 mRNA in the OCP group showed no significant increase. Furthermore, in cases, ICAM-1 mRNA expression positively correlated with body mass index (BMI) (p = 0.01), fasting insulin (p = 0.01), insulin 2 h p = 0.02), glucose 2 h (p = 0.01) and triglycerides (p = 0.01). TNF-α mRNA expression positively correlated with fasting insulin (p = 0.0007). MCP-1 mRNA expression positively correlated with (BMI) (p = 0.002). Conclusion OCPs helped reduce clinical hyperandrogenism and regularise menstrual cycles in women with PCOS. However, OCP use was associated with increased fold expression of inflammatory markers which positively correlated with metabolic abnormalities.

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Evaluation of antioxidant defense markers in relation to hormonal and insulin parameters in women with polycystic ovary syndrome (PCOS): A case-control study

Cited by 30 publications

References 37 publications

Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity – A narrative review

Antioxidant effects of vitamin E and risk of cardiovascular disease in women with obesity – A narrative review

Therapeutic efficacy of Trifolium pratense L. on letrozole induced polycystic ovary syndrome in rats

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