Evaluation of Antioxidant and Antimicrobial Activity of Artocarpus altilis Against Human Pathogens

Jiyauddin, K; Zulhabri, O; Aishah, U A M; Rasha, S; Hamid, Kaiser; Qamar, Muhammad Usman; Budiasih, Sri; Jawad, Abd Al Latif Mohamed; Samer, A D; Kaleemullah, Mohammed; Rasny, Mohamed; Eddy, Y; Fadli, Afrizal Lathiful; Junainah, A H

doi:10.20510/ukjpb/2/i4/91110

Cited by 7 publications

(5 citation statements)

References 8 publications

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“…Alkaloids, saponins, and iridoids were not detected in all the extracts. All five extracts contained the same chemical groups as reported in the extracts from Malaysian breadfruit [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Composition, Antibacterial Activity, and Antioxidant Properties of the Artocarpus altilis Fruits to Promote Their Consumption in the Comoros Islands as Potential Health-Promoting Food or a Source of Bioactive Molecules for the Food Industry

Soifoini¹,

Donno

Jeannoda

et al. 2021

Foods

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The present study aimed to evaluate the health-promoting potential of breadfruit (Artocarpus altilis (Parkinson) Fosberg, Moraceae family), a traditional Comorian food, considering the sample variability according to geographic localisation. Moreover, the main aims of this research were also to promote its consumption in the Comoros Islands as potential health-promoting food and evaluate it as a source of bioactive molecules for the food industry thanks to its antioxidant and antibacterial properties. Investigations on biologically active substances were carried out on the extracts obtained from breadfruit flours from five regions of Grande Comore (Ngazidja), the main island in Comoros. Phytochemical screening revealed the presence of tannins and polyphenols, flavonoids, leucoanthocyanins, steroids, and triterpenes. The considered secondary metabolites were phenolic compounds, vitamin C, monoterpenes, and organic acids. The contents of total phenolic compounds (mgGAE/100 g of dry weight—DW) in the extracts ranged from 29.69 ± 1.40 (breadfruit from Mbadjini—ExMBA) to 96.14 ± 2.07 (breadfruit from Itsandra—ExITS). These compounds included flavanols, flavonols, cinnamic acid and benzoic acid derivatives, and tannins which were detected at different levels in the different extracts. Chlorogenic acid presented the highest levels between 26.57 ± 0.31 mg/100 g DW (ExMIT) and 43.80 ± 5.43 mg/100 g DW (ExMBA). Quercetin was by far the most quantitatively important flavonol with levels ranging from 14.68 ± 0.19 mg/100 g DW (ExMIT) to 29.60 ± 0.28 mg/100 g DW (ExITS). The extracts were also rich in organic acids and monoterpenes. Quinic acid with contents ranging from 77.25 ± 6.04 mg/100 g DW (ExMBA) to 658.56 ± 0.25 mg/100 g DW of ExHAM was the most important organic acid in all the breadfruit extracts, while limonene was quantitatively the main monoterpene with contents between 85.86 ± 0.23 mg/100 g DW (ExMIT) and 565.45 ± 0.24 mg/100 g DW (ExITS). The antibacterial activity of the extracts was evaluated on twelve pathogens including six Gram (+) bacteria and six Gram (−) bacteria. By the solid medium disc method, except for Escherichia coli and Pseudomonas aeruginosa, all the bacteria were sensitive to one or more extracts. Inhibitory Halo Diameters (IHDs) ranged from 8 mm to 16 mm. Salmonella enterica, Clostridium perfringens, and Vibrio fischeri were the most sensitive with IHD > 14 mm for ExITS. By the liquid microdilution method, MICs ranged from 3.12 mg/mL to 50 mg/mL and varied depending on the extract. Bacillus megaterium was the most sensitive with MICs ≤ 12.5 mg/mL. Pseudomonas aeruginosa, Shigella flexneri, and Vibrio fischeri were the least sensitive with all MICs ≥ 12.5 mg/mL. ExHAM was most effective with a MIC of 3.12 mg/mL on Staphylococcus aureus and 6.25 mg/mL on Salmonella enterica. The antioxidant power of the extracts was evaluated by the FRAP method. The activity ranged from 5.44 ± 0.35 (ExMBA) to 14.83 ± 0.11 mmol Fe2+/kg DW (ExHAM). Breadfruit from different regions of Comoros contained different classes of secondary metabolites well known for their important pharmacological properties. The results of this study on phenolics, monoterpenes, and organic acids have provided new data on these fruits. The obtained results showed that breadfruit from the biggest island of the Union of Comoros also presented antimicrobial and antioxidant properties, even if some differences in effectiveness existed between fruits from different regions.

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“…Alkaloids, saponins, and iridoids were not detected in all the extracts. All five extracts contained the same chemical groups as reported in the extracts from Malaysian breadfruit [ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Phytochemical Composition, Antibacterial Activity, and Antioxidant Properties of the Artocarpus altilis Fruits to Promote Their Consumption in the Comoros Islands as Potential Health-Promoting Food or a Source of Bioactive Molecules for the Food Industry

Soifoini¹,

Donno

Jeannoda

et al. 2021

Foods

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“…Antimicrobial activity was tested using a modified discs diffusion assay (DDA) method 34,35 . antimicrobial activity were average of triplicate.…”

Section: Evaluation Of Antimicrobial Activitymentioning

confidence: 99%

Phytoconstituents, Antioxidant and Antimicrobial Activities of Livistona chinensis (Jacquin), Saribus rotundifolius (Lam.) Blume and Areca catechu Linnaeus Nuts

Essien

Antia

Etuk

2017

PBJ

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Livistona chinensis, Saribus rotundifolius and Areca catechu are palms primarily cultivated for ornamental purposes and also utilized in herbal remedies. The chemical and biological studies were conducted using standard procedures. Phytochemical screening revealed the presence of alkaloids, saponins, cardiac glycosides, terpenes, de-oxy sugars, anthraquinones, phenols, flavonoids and phlobatannins in varying amounts. The total phenolics content ranged from 52.0-245.0 mg/g, DPPH radical inhibition (87.30-90.55%, 2.0 mg/ml), iron chelating activity (27.3-65.0%, 0.5 mg/ml), hydrogen peroxide scavenging (93.18-98.46%, 0.5 mg/ml), and molybdate ion reduction capacity (15.93-58.30%, 0.5 mg/ml). L. chinensis extract showed notable antimicrobial activity against B. subtilis, P. aeruginosaand C. albicans (MIC = 75-100 µg/ml) while A. catechu and S. rotundifolius extracts were potent against all test pathogens (75-100 µg/ml), except S. typhi (150 µg/ml). However, no appreciable cytotoxic effects on human cervical (HeLa), lung (H460), breast (MCF-7) and prostate (PC-3) cancer cells at 30 µg/mL was observed for the extracts. The notable antioxidant and antimicrobial activities of the palm extracts are a function of their inherent bioactive constituents and a potential source of medicinally useful compounds. The chemical and biological assessment of S. rotundifolius palm nuts is reported for the first time.

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“…Traditional herbal medicine is a common practice in various human cultures in the world including in Malaysia. The major component of this practice is the usage of medicinal plants, which the leaves are the most common part of a plant that is used in preparing herbal medicine 1,2 . As for lately, this practice has been gaining a significant amount of attention globally 3 .…”

Section: Introductionmentioning

confidence: 99%

The Phytochemical Analysis and Synergistic Antifungal Effect of Etlingera elatior Jack. Flowers and Murraya koenigii Spreng. Leaves against Candida albican

Othman¹,

Ali²,

Zajmi³

2020

J Pure Appl Microbiol

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Traditional medicinal plant possessed antimicrobial properties. Candidiasis is an infection of Candida albicans which has developed resistance towards antifungal drugs. The extracts of Murraya koenigii Spreng leaves and Etlingera elatior Jack flowers were used as antifungal agents individually and in combination against C. albicans. Both extracts were tested for the presence of phytochemicals (alkaloids, tannins, flavonoids, glycosides and saponins). Individual extracts were examined for antifungal activity using Kirby-Bauer test. The minimum inhibitory concentration (MIC) and the minimum fungicidal concentration (MFC) were evaluated using microdilution broth assay and checkerboard assay. The extracts of both plants were positive for the presence of phytochemicals flavonoids, alkaloids, tannins, glycosides and saponins. The inhibition zone of M. koenigii leaf and E. elatior flower extracts were 8.33 mm and 8.17 mm respectively. The MIC of M. koenigii and E. elatior ranged from 200 mg/mL to 400 mg/mL and in combination, the extracts were indifferent towards C. albicans (FIC=1.0). MFC revealed there was no visible growth of C. albicans on SDA plate. M. koenigii and E. elatior have potential to be used individually or in combination as antifungal agents against C. albicans.

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Evaluation of Antioxidant and Antimicrobial Activity of Artocarpus altilis Against Human Pathogens

Cited by 7 publications

References 8 publications

Phytochemical Composition, Antibacterial Activity, and Antioxidant Properties of the Artocarpus altilis Fruits to Promote Their Consumption in the Comoros Islands as Potential Health-Promoting Food or a Source of Bioactive Molecules for the Food Industry

Phytochemical Composition, Antibacterial Activity, and Antioxidant Properties of the Artocarpus altilis Fruits to Promote Their Consumption in the Comoros Islands as Potential Health-Promoting Food or a Source of Bioactive Molecules for the Food Industry

Phytoconstituents, Antioxidant and Antimicrobial Activities of Livistona chinensis (Jacquin), Saribus rotundifolius (Lam.) Blume and Areca catechu Linnaeus Nuts

The Phytochemical Analysis and Synergistic Antifungal Effect of Etlingera elatior Jack. Flowers and Murraya koenigii Spreng. Leaves against Candida albican

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