Evaluation of Antimicrobial Susceptibility of Staphylococcus aureus Strains Isolated from Blood Cultures in Konya Training and Research Hospital Between the Years 2009-2013

Abstract

ÖZET SUMMARY Evaluation of Antimicrobial Susceptibility of Staphylococcus aureus Strains Isolated from Blood Cultures in Konya Training and Research Hospital Between the Years 2009-2013 Bloodstream infections have high morbidity and mortality rates. Staphylococcus aureus is one of the most common causes of bloodstream infections. Evaluation of frequency of microorganisms isolated from blood cultures and antibiotic susceptibility can provide clinicians with relevant infomation for the emprical treatment of patients. In this study, antimicrobial susceptibility patterns of S.aureus strains isolated from bloodstream infections have been evaluated. Blood cultures were performed with automated system; BACTEC 9240 (Becton Dickinson, USA). Phoenix-100 (Becton Dickinson-USA) automated system were used for identification and antimicrobial susceptibility. Susceptibility was determined using the CLSI interpretive criteria.During a period of five years, a total of 409 isolates of S.aureus were evaluated and 33 % were found methicillinresistant. The susceptibility rates of trimethoprim-sulfamethoxazole, gentamycin, erythromycin, tetracycline, clindamycin and rifampin in methicillin-resistant strains were 74.3 %, 36 %, 16.6 %, 41 %, 37.2 %, 48.6 % respectively. The susceptibility rates of trimethoprim-sulfamethoxazole, gentamycin, erythromycin, tetracycline, clindamycin and rifampin in methicillinsuscebtible strains were 89 %, 73.8 %, 59.7 %, 74 %, 66 %, 76.6 % respectively. The uncontrolled use of antibiotics increase the development of antimicrobial resistance. The creation of rational antibiotic use awareness and periodically evaluation of their own resistance profiles for each center and share with related committees would be the preventive factors against resistance development.

Staphylococcus aureus and Methicillin Resistant Staphylococcus aureus (MRSA) Carriage and Infections

“…When S. aureus strains isolated from hospitalized patients and wound samples were examined in the study, 75% of wound-borne strains, 51% of skin-borne strains and 74% of strains obtained from hospital beds were identified as MRSA. Yüksekkaya et al stated that 48% of the cases with MRSA in blood culture were isolated from intensive care units, 47% from internal clinics, and 5% from surgical clinics [40]. In the study conducted by Zencir et al on hospitalized patients, it was reported that 84.6% of the patients with MRSA growth in their blood culture were obtained from the intensive care units and 14.4% from the samples from other clinics [39].…”