Antimicrobial Resistance (AMR) has emerged as a critical global concern in the 21st century, presenting a "Quiet Pandemic" with escalating infection occurrences and a dearth of novel antimicrobial drugs. This paper explores the causes, prevalence, and regional implications of AMR, focusing on the One Health Approach initiated by international organizations like OIE and FAO. In Pakistan, a national action plan has been implemented to address AMR. The causes of AMR include the unnecessary use and misuse of antimicrobials, inappropriate prescribing patterns, and the lack of new novel antibiotics. The global prevalence of AMR is particularly high in sub-Saharan Africa and low-to middle-income countries, with specific concerns about colistin resistance mediated by MCR-1 in China. Insufficient public understanding of antimicrobials is also identified as a significant factor contributing to AMR. A comparative study between the UK and India highlights variations in public awareness, potentially impacting the incidence of infectious diseases. Vigilant monitoring of AMR-related infections and mortality rates is crucial, with projections indicating a potential rise in global mortality by 2050. The roles of key bacteria, including Escherichia coli, Staphylococcus aureus, Salmonella, and Brucella, in the spread of AMR are discussed. E. coli, for example, harbors resistance genes from both human and animal sources, posing a threat to both populations. Similarly, the emergence of methicillin-resistant Staphylococcus aureus (MRSA) complicates treatment, while Salmonella contributes to global foodborne illnesses.