Evaluation of Antimicrobial and Antioxidant Properties of Pithecolobine Isolated from<i>Albizia saman</i>

Thippeswamy, S.; Mohana, Devihalli Chikkaiah; Abhishek, Rayasandra Umesh; Manjunath, K.

doi:10.1080/10496475.2014.996695

Cited by 3 publications

(1 citation statement)

References 18 publications

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“…Moreover, Budmunchiamine A, isolated from A. amara, showed a concentration-dependent bactericidal activity against Gram-positive (S. aureus, S. faecalis) and Gram-negative bacteria (E. coli, K. pneumonia, P. aeruginosa) and an antifungal activity against C. albicans and C. neoformans. In addition, it exhibited moderate antioxidant activity with an IC 50 value of 400 µg/mL, determined via the DPPH method, and a 67.8% inhibition of carotene/linoleic acid at 1000 µg/mL [21]. Budmunchiamine A significantly inhibited the growth of a wide range of seed-borne corn fungi, including aflatoxin from Aspergillus flavus, and increased the seedling vigor index in vivo at a lower concentration (1.0 g/kg) than the pithecolobin molecule (2.0 g/kg) [22].…”

Section: Discussionmentioning

confidence: 99%

Acacia senegal Budmunchiamines as a Potential Adjuvant for Rejuvenating Phenicol Activities towards Escherichia coli-Resistant Strains

Magnini

Pedinielli

Vergalli

et al. 2023

IJMS

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The continuous emergence of bacterial resistance alters the activities of different antibiotic families and requires appropriate strategies to solve therapeutic impasses. Medicinal plants are an attractive source for researching alternative and original therapeutic molecules. In this study, the fractionation of natural extracts from A. senegal and the determination of antibacterial activities are associated with molecular networking and tandem mass spectrometry (MS/MS) data used to characterize active molecule(s). The activities of the combinations, which included various fractions plus an antibiotic, were investigated using the “chessboard” test. Bio-guided fractionation allowed the authors to obtain individually active or synergistic fractions with chloramphenicol activity. An LC-MS/MS analysis of the fraction of interest and molecular array reorganization showed that most identified compounds are Budmunchiamines (macrocyclic alkaloids). This study describes an interesting source of bioactive secondary metabolites structurally related to Budmunchiamines that are able to rejuvenate a significant chloramphenicol activity in strains that produce an AcrB efflux pump. They will pave the way for researching new active molecules for restoring the activity of antibiotics that are substrates of efflux pumps in enterobacterial-resistant strains.

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Section: Discussionmentioning

confidence: 99%

Acacia senegal Budmunchiamines as a Potential Adjuvant for Rejuvenating Phenicol Activities towards Escherichia coli-Resistant Strains

Magnini

Pedinielli

Vergalli

et al. 2023

IJMS

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Chemical Characterization of Schefflera actinophylla (Endl.) Harms Essential Oil: Antifungal and Antimycotoxin Activities for Safe Storage of Food Grains

Roshan

Venkatesh

Mohana

2021

Journal of Biologically Active Products from Nature

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Formulation and Evaluation of Herbal Hand Sanitizer Based on Stevia (Stevia rebaudiana)

Harismah

Ariningrum

Fuadi

et al. 2021

J. Phys.: Conf. Ser.

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The purpose of this study was to analyze the quality of herbal hand sanitizer based on stevia in the addition of trembesi (Albizia saman (Jacq.) Merr) leaf extract. Experimental research in the laboratory, the study used two factorial Completely Randomized Design, namely stevia extract (1.0; 0.75; 0.50; 0.25; 0.0%) and trembesi extract (0; 0.25;0, 5;0.75; 1.0%) with two repetitions. Each formulation was tested according to SNI 0625881992. The results showed that all formulation comply with SNI-06-2588-1992 standards.

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Evaluation of Antimicrobial and Antioxidant Properties of Pithecolobine Isolated fromAlbizia saman

Abstract: Pithecolobine isolated from alkaloid extract of

Cited by 3 publications

References 18 publications

Acacia senegal Budmunchiamines as a Potential Adjuvant for Rejuvenating Phenicol Activities towards Escherichia coli-Resistant Strains

Acacia senegal Budmunchiamines as a Potential Adjuvant for Rejuvenating Phenicol Activities towards Escherichia coli-Resistant Strains

Chemical Characterization of Schefflera actinophylla (Endl.) Harms Essential Oil: Antifungal and Antimycotoxin Activities for Safe Storage of Food Grains

Formulation and Evaluation of Herbal Hand Sanitizer Based on Stevia (Stevia rebaudiana)

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