Abstract:Introduction:The antimicrobial, antioxidant and cytotoxicity activities of the ethanolic and aqueous extracts of Targets multiflora Kunth were evaluated, which were collected in the province of Yauyos department of Lima-Perú. The antimicrobial activity was evaluated by the well diffusion method on agar against Staphylococcus aureus ATCC 6538, Escherichia coli ATCC 8739, Method: Pseudomonas aeruginosa ATCC 9027, Bacillus subtilis ATCC 6633, Candida albicans ATCC 14053 and Aspergillus niger ATCC 16404. Antioxida… Show more
“…Clinopodium gilliesii Kuntze [Lamiaceae], Mutisia acuminata var. hirsuta (Meyen) Cabrera [Asteraceae], and Tagetes multiflora Kunth [Asteraceae) are three native species that grow in the Andean Altiplano in the north of Chile [ 10 , 11 , 12 ]. C. gilliesii —commonly known as Muña-Muña—is a highly valued and aromatic native herb that grows between Arica y Parinacota and Atacama regions and has been used in traditional medicine to treat high blood pressure, stomachaches, heart pain, female sterility, and as an aphrodisiac [ 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…ex Willd. [Ephedraceae] for the treatment of urinary tract infection [ 12 ]. Several monoterpenes have been identified from the essential oils of the aerial parts from Chilean [ 10 ] and Argentinian C. gilliessi [ 14 ].…”
This research aimed to identify the phenolic profile and composition of the aerial parts of three native species used in traditional medicine in the Andean Altiplano of northern Chile: Clinopodium gilliesii (Benth.) Kuntze [Lamiaceae] (commonly known as Muña-Muña), Mutisia acuminata Ruiz & Pav. var. hirsuta (Meyen) Cabrera [Asteraceae] (commonly known as Chinchircoma), and Tagetes multiflora (Kunth), [Asteraceae] (commonly known as Gracilis), as well as to evaluate their potential inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Polyphenolic enriched-extracts (PEEs) of the species were prepared and analyzed and the main components were quantified using HPLC-DAD. In total, 30 phenolic compounds were identified and quantified in all species, including simple phenolics, hydroxycinnamic acids, flavan-3-ols (monomers and polymers), flavanones, and flavonols. In addition, other main phenolics from the extracts were tentatively identified by ESI-MS-MS high-resolution analysis. T. multiflora extract showed the greatest anti-AChE and BChE activity in comparison with C. gilliesii and M. acuminata extracts, being the anti-AChE and BChE activity weak in all extracts in comparison to galantamine control. To comprise to better understand the interactions between cholinesterase enzymes and the main phenolics identified in T. multiflora, molecular docking analysis was conducted.
“…Clinopodium gilliesii Kuntze [Lamiaceae], Mutisia acuminata var. hirsuta (Meyen) Cabrera [Asteraceae], and Tagetes multiflora Kunth [Asteraceae) are three native species that grow in the Andean Altiplano in the north of Chile [ 10 , 11 , 12 ]. C. gilliesii —commonly known as Muña-Muña—is a highly valued and aromatic native herb that grows between Arica y Parinacota and Atacama regions and has been used in traditional medicine to treat high blood pressure, stomachaches, heart pain, female sterility, and as an aphrodisiac [ 10 ].…”
Section: Introductionmentioning
confidence: 99%
“…ex Willd. [Ephedraceae] for the treatment of urinary tract infection [ 12 ]. Several monoterpenes have been identified from the essential oils of the aerial parts from Chilean [ 10 ] and Argentinian C. gilliessi [ 14 ].…”
This research aimed to identify the phenolic profile and composition of the aerial parts of three native species used in traditional medicine in the Andean Altiplano of northern Chile: Clinopodium gilliesii (Benth.) Kuntze [Lamiaceae] (commonly known as Muña-Muña), Mutisia acuminata Ruiz & Pav. var. hirsuta (Meyen) Cabrera [Asteraceae] (commonly known as Chinchircoma), and Tagetes multiflora (Kunth), [Asteraceae] (commonly known as Gracilis), as well as to evaluate their potential inhibitory effects against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Polyphenolic enriched-extracts (PEEs) of the species were prepared and analyzed and the main components were quantified using HPLC-DAD. In total, 30 phenolic compounds were identified and quantified in all species, including simple phenolics, hydroxycinnamic acids, flavan-3-ols (monomers and polymers), flavanones, and flavonols. In addition, other main phenolics from the extracts were tentatively identified by ESI-MS-MS high-resolution analysis. T. multiflora extract showed the greatest anti-AChE and BChE activity in comparison with C. gilliesii and M. acuminata extracts, being the anti-AChE and BChE activity weak in all extracts in comparison to galantamine control. To comprise to better understand the interactions between cholinesterase enzymes and the main phenolics identified in T. multiflora, molecular docking analysis was conducted.
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