Evaluation of antimicrobial activities of &lt;i&gt;Combretum micranthum&lt;/i&gt; L.

Taura, D. W.; Arzai, AH; Oyeyi, T. I.

doi:10.4314/bajopas.v2i1.58540

Cited by 5 publications

(7 citation statements)

References 3 publications

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“…It produced significant hypoglycemic and antidiabetic activity comparable to the effect of the standard drug (0.6 mg/kg glibenclamide). [55] This result was confirmed by the study by Odoh et al (2020). The extract of C. micranthum leaves was found to possess a significant and non-dose dependent (p < 0.05) antidiabetic effect in rats at doses of 100 (67.34 %) and 200 mg/kg (60.56 %), which was comparable to 5 mg/kg glibenclamide (90.62 %).…”

Section: Antidiabetic Activitysupporting

confidence: 67%

“…All test organisms were studied using the agar diffusion method and were sensitive to the crude extracts except Escherichia coli and C. albicans . The extracts had a broader spectrum of activity than the commercial antibiotics tested against the isolates [55] …”

Section: Pharmacological Activitiesmentioning

confidence: 97%

“…The extracts had a broader spectrum of activity than the commercial antibiotics tested against the isolates. [55] Udoh et al (2012) evaluated the antibacterial activity of methanolic and aqueous extracts of leaves, root bark and stem bark against 25 different nosocomial isolates of S. aureus, E. coli, K. pneumoniae, Proteus mirabilis, P. aeruginosa, Enterococcus faecalis, Streptococcus pyogenes and S. pneumoniae using the agar well diffusion method. The extracts had shown high antimicrobial efficacy against different 200 clinical isolates both Gram (+) and Gram (À ).…”

Section: Antibacterial Activitymentioning

confidence: 99%

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Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Tine,

Sene,

Gaye

et al. 2024

Chemistry & Biodiversity

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Combretum micranthum (Combretaceae) is a medicinal plant widely known and used in Africa to treat a variety of conditions such as diabetes, fever, coughs, bronchitis, diarrhea, pain, malaria and liver disorders, among others. Due to its wide traditional use, in this review, published scientific reports on its composition and pharmacological properties were explored by conducting a literature search of databases. To date, 155 organic compounds including 34 flavonoids, 16 phenolic acids, 14 alkaloids, 15 fatty acids, 14 terpenoids/steroids, 24 amino acids, 8 carbohydrate substances and 30 other organic compounds have been identified from this plant. In addition to these organic compounds, 6 minerals (potassium nitrate, calcium, magnesium, potassium, sodium, iron and zinc) have also been reported. In vitro and in vivo studies have shown that these phytochemicals and plant extracts have a wide range of pharmacological potential, including antibacterial, antiviral, antioxidant, antidiabetic, anti‐inflammatory, analgesic, antihypertensive, nephroprotective, hepatoprotective, anxiolytic, anti‐cholinesterase and antidiarrheal activities. Additionally, no harmful effects have been revealed through studies. Thus, this study could constitute a valuable reference for the valorization of C. micranthum in the pharmaceutical industry.

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Section: Antidiabetic Activitysupporting

confidence: 67%

Section: Pharmacological Activitiesmentioning

confidence: 97%

Section: Antibacterial Activitymentioning

confidence: 99%

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Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Tine,

Sene,

Gaye

et al. 2024

Chemistry & Biodiversity

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“…According to Burkill (1985), fruit powder is used to treat weeping skin diseases in children (impetigo type) [9]. In Senegal, the dried leaves are sold tied in twigs and tied [7].…”

Section: Optimization Of the Aqueous Decoction Process Of Combretum M...mentioning

confidence: 99%

Optimization of the Aqueous Decoction Process of <i>Combretum micranthum</i> Leaves

Faye¹,

Ndiaye²,

Baldé³

et al. 2023

FNS

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This work proposes to compare the extraction of total polyphenols and the coloring obtained after several series of decoction at 100˚C/20min, of whole or crushed leaves of Combretum micranthum. The total phenolic content of the extracts obtained after decoction was determined by Folin's method. The color parameters were measured using a colorimeter based on the CIELAB system. The analysis of variance (ANOVA) shows significant differences (p < 0.05) on different parameters evaluated. The Minitab 19 software was used to classify the extracts according to the color parameters (L, A, and B). The results showed that the maximum of polyphenols (21.67%) was extracted in the crushed leaves after three series of decoctions while with the whole leaves the maximum of 16.17% is obtained after six series of decoctions. The concentration of total polyphenols becomes low from four series of decoctions with 0.146 g•AG•100 g −1 MS. The red and yellow coloring drops respectively by 85 and 69% with crushed leaves and 64 and 21% with whole leaves. The conductivity and the brix of the extracts fall according to the series of decoctions. These results show that for optimal use of C. micranthum leaves in traditional medicine, crushed leaves and three series of decoctions are indicated and sufficient.

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“…The herbal beverage is commonly used to promote weight loss, digestion (Abdullahi et al 2014), diuresis and as a mild antibiotic (Taura, Arzai & Oyeyi 2009) to the urinary tract (Coulidiati et al 2011;Fern 2014). The leaf extract of C. micranthum has been shown to possess analgesic, antiinflammatory (Eloff et al 2008), antidiabetic (Chika & Bello 2010), antibacterial (Abdel Kader et al 2020;Jared et al 2018), anti-hypertensive properties (Abdullahi et al 2014;Arumugam et al 2013) and it also prevents nosocomial infection (Udoh et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Assessment of anxiolytic potential and acute toxicity study of Combretum micranthum G. Don. leaves (Combretaceae)

Amali

Atunwa

Omotesho

et al. 2020

Journal of Medicinal Plants for Economic Development

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Background: Combretum micranthum G. Don. (Combretaceae) is an ethnomedicinally valuable, undomesticated and indigenous shrub of West Africa. However, its anxiolytic potential have not been reported despite its ethanolic extract being used ethnomedicinally in the management of anxiety disorders.Aim: To determine the acute toxicity effect and assess the behavioural effects and anxiolytic potential of C. micranthum G. Don. leaves in mice.Settings: This study is an experimental design to evaluate the ethnomedicinal claim of Combretum micranthum G. Don using animal models of anxiety.Methods: Fifty-six male and female mice, ranging in weight between 20 g and 30 g were randomly distributed into three main groups. The first group of mice (n = 6) was assigned for toxicity assessment (LD 50 ) study using the guideline of Organization for Economic Cooperation and Development (OECD). The second group of mice for behavioural study (n = 25) was further divided into five sub-groups. Sub-groups I, II and III were orally administered 500 mg/kg, 1000 mg/kg, 2000 mg/kg of ethanolic extract of C. micranthum (CmEE), respectively, whilst IV and V were intraperitoneally administered 1 mg/kg diazepam and normal saline 0.5 mL, respectively. They were thereafter evaluated for novelty-induced behaviours: locomotion, rearing and grooming using Open Field Test (OFT). The third group of mice (n = 25) was treated similar to the pattern used in behavioural study and evaluated for anxiolytic activity of CmEE using elevated plus maze (EPM) model. Data were expressed as mean ± standard error of mean (S.E.M) and analysed using Student's-t test, and one-way analysis of variance (ANOVA) followed by Student-Newman-Keuls (SNK) test with values of p < 0.05 considered significant. Results:The percentage yield of ethanolic leaf extract of C. micranthum was 14.28% weight/ weight (w/w). Combretum micranthum showed no toxicity when administered orally to mice (LD 50 ≥ 2000 mg/kg). Groups administered 500, 1000 and 2000 mg/kg of CmEE exhibited decreased locomotion (p < 0.05) when compared with saline group. There was significant decrease in rearing at 2000 mg/kg but increase in grooming in mice administered 2000 mg/kg of CmEE was recorded. The groups administered 500, 1000 and 2000 mg/kg of CmEE showed increased percentage time spent in the open arm in a dose-dependent pattern (33.3%, 41.6% and 55.4%, respectively) when compared with the saline group. There were significant dosedependent decreases in the indices of open arm avoidance at 1000 (48.9) and 2000 mg/kg (41.4) of CmEE. Conclusion:Combretum micranthum is non-toxic and preliminary data indicated that it possesses anxiolytic potential. However, it is recommended that further assays using other specific models of anxiety to determine its probable mechanism(s) of action should be explored.

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Evaluation of antimicrobial activities of <i>Combretum micranthum</i> L.

Cited by 5 publications

References 3 publications

Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Optimization of the Aqueous Decoction Process of <i>Combretum micranthum</i> Leaves

Assessment of anxiolytic potential and acute toxicity study of Combretum micranthum G. Don. leaves (Combretaceae)

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Evaluation of antimicrobial activities of <i>Combretum micranthum</i> L.

Cited by 5 publications

References 3 publications

Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Combretum micranthum G. Don (Combretaceae): A Review on Traditional Uses, Phytochemistry, Pharmacology and Toxicology

Optimization of the Aqueous Decoction Process of &lt;i&gt;Combretum micranthum&lt;/i&gt; Leaves

Assessment of anxiolytic potential and acute toxicity study of Combretum micranthum G. Don. leaves (Combretaceae)

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Optimization of the Aqueous Decoction Process of <i>Combretum micranthum</i> Leaves